Conserved Protein Domain Family
SGNH_hydrolase_like_4

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cd04501: SGNH_hydrolase_like_4 
Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.
Statistics
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PSSM-Id: 239945
Aligned: 16 rows
Threshold Bit Score: 198.32
Created: 3-Oct-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Citation:PMID 7773790
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Comment:the histidine side chain may be oriented by a backbone oxygen or by an acidic sidechain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                               #                            #          
NP_350038     1 MKLVCIGDSLTYGYgvsstsswvellkahfsinVINKGINGDTTSGILSRSYSDivKEKPNYVIIMAGTNDMlmdy---s 77  Clostridium acet...
YP_519477    54 TKVVAIGDSFTFGYpgntenswpavlgqtsqieVVNKGLKSQTAQDLYSRFDADvlAEKPGRVIIFVGNGDAikev---p 130 Desulfitobacteri...
GAA01027    173 DCVVCLGDSITYGYpygpdtswvracsekldmkLINKGVNGDTTRQMKRRFERDviSFEPAYVIIMGGTNDVwvgt---w 249 Pelotomaculum th...
ABI68471      5 LRIVCLGDSITYGFpwgpqaswvtmldevldgeVINRGINGNTTSNMLARFERAvlKYNPSHVIIMGGTNDVicge---s 81  Syntrophomonas w...
ZP_00525698  71 GRVVFMGDSITDFWkldes---------fpgkpYVNRGIGGQVTSQMLVRLYPDviALRPAVMTILAGTNDIarnngpst 141 Solibacter usita...
CAJ68440      1 MKIVCLGDSLTYGFgvsrsnswtnivnketrleIVNKGINGDTTSGMLARFNEDvvKNSPDIVFIMGGTNDFiaga---g 77  Clostridium diff...
ZP_00526989  67 KRVIFFGDQVTERWgqgsgk-------ffpgkgYLNRGIGGQTTAQMLVRFHQDvvALKPAVVVIEGGMNDLlva----t 135 Solibacter usita...
ZP_01148495 112 NKILCLGDSITYGYpdgpafswvtrviestgyqMLNRGINGETTGQMLVRMRTDviPEKPAYLIFAGGHNDGwqkv---s 188 Desulfotomaculum...
BAB81940      1 MNIICIGDSLTFGYgvgqenswv-sllndeknkFINKGVNGDTSTGILSRIYEIlkSSDSKICLIMCGSNDIimnk---s 76  Clostridium perf...
YP_359359     2 VEFVFLGDSLTYGFpygptaswvnlsaeklgvsFLNLGVCGDTLEDMKERFKRE--RILGNTLVLLGGTNDIyvnr---p 76  Carboxydothermus...
Feature 1                                                                                       
NP_350038    78 tkLIKDNIELLLKea-keNNITPILALQPPvisplaktywdse------------------------idyekvaislldY 132 Clostridium acet...
YP_519477   131 leTFQQHIKAMVEka-esNHIIPILALPLPytgvq---------------------------------------ntikeF 170 Desulfitobacteri...
GAA01027    250 qeKIRENVEEMVTra-feEGICLVVGLPVPmdlsnyegflpg--------------------------dmscavceldtF 302 Pelotomaculum th...
ABI68471     82 fdRITWNIREMVEra-ekARIKVVLGIPTAvdepyw-------------------------------------ekllvrL 123 Syntrophomonas w...
ZP_00525698 142 peMIQQNIMAMTEla-qkHGIKVLLCSILPvsdypflaqqaaagrgaspppqggrgpggrgpmvrqrmtvgrppadilkL 220 Solibacter usita...
CAJ68440     78 neIINSNIMAMVHqs-ysKNIIPIIGIPLKpdipnvredwscf------------------------tdfnivsqnlesY 132 Clostridium diff...
ZP_00526989 136 egVMADNFLSMMDia-raNGIRVVLASVTPvcdcytkqtg------------------------------lrpqgkiisL 184 Solibacter usita...
ZP_01148495 189 lgEVKQNVRQVVGma-leHGICPVMVLPSPlnieqilqcyegs-----------------------rqeaedynnalseT 244 Desulfotomaculum...
BAB81940     77 isSIIDNISLMTDdc-nsLNIKPIILSPPKiygylaikrwdss------------------------idyekcnsklenY 131 Clostridium perf...
YP_359359    77 tsEILQDAREIITvakerNFSAIVLASPLPvleeewa------------------------------------derlkiL 120 Carboxydothermus...
Feature 1                                           #  #                 
NP_350038   133 IRWAKAYCINnniAFVSFNIVfinkd---nieaLYNDGIHPNSEGHKLMFNELSKIL 186 Clostridium acetobutylicum ATCC 824
YP_519477   171 REWESSYAKEkniLVLDFATVlmdadnvyleglLSKEANYPSKEGYKLMGEYASRVL 227 Desulfitobacterium hafniense Y51
GAA01027    303 RNWLEEFAESnllPVMDFYTPlldpatgkanpaYFEDDSHPNVNGYRALAGAAERVL 359 Pelotomaculum thermopropionicum SI
ABI68471    124 RSWIKDLARQkglQIIDFSRPfydekgrvrsdlLLADGGHPSRAGYQAMFAQIDLKI 180 Syntrophomonas wolfei subsp. wolfei str...
ZP_00525698 221 NAWMKSYAQQvnaIYVDYFSAlvdekg-wlkdgLAADGLHPNAEGYKIMSPIVSAAI 276 Solibacter usitatus Ellin6076
CAJ68440    133 SYWIKKFCMTfntNFVDFYSEynknmelegykkLYFDGLHPTKEGHRIMADIFINSI 189 Clostridium difficile 630
ZP_00526989 185 NGWIKDFAAAssaVFLNYYSAladgr--nfkkeLTDDGLLPNDAAYGVMAPLAEKAI 239 Solibacter usitatus Ellin6076
ZP_01148495 245 RQWIGQYAQEmgfFALDFYTPllvegsdqgnpqYLLDGGHPTHEGYRVLGDAAIKQL 301 Desulfotomaculum reducens MI-1
BAB81940    132 TRGLNLFCEKnnlLFIDLNSNlpf------dslNYTDGLHLSIKGNILVSNLVKMSL 182 Clostridium perfringens str. 13
YP_359359   121 GRKYREIAGElgvKYLDFYEPfkkll--knnpgVLIDGLHPSREGYRFMAQIFLSFL 175 Carboxydothermus hydrogenoformans Z-2901

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