1XJV


Conserved Protein Domain Family
hPOT1_OB2
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cd04498: hPOT1_OB2 
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hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with the sequence GGTTAG. The hPOT1 monomer consists of two closely connected OB folds (OB1-OB2) which cooperate to bind telomeric ssDNA. OB1 makes more extensive contact with the ssDNA than OB2. OB2 protects the 3' end of the ssDNA. hPOT1 is implicated in telomere length regulation.
Links
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Statistics
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PSSM-Id: 239944
Aligned: 9 rows
Threshold Bit Score: 129.846
Created: 19-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ssDNA bindingbinding surface
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ssDNA binding [nucleic acid binding site]
Evidence:
  • Structure:1XJV_A; Human POT1 binds telomeric ssDNA; defined at 3.5A contacts.
  • Comment:The hPOT1 monomer consists of two closely-associated OB folds (OB1-OB2), which cooperate to bind telomeric ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #                                                                               
1XJV_A       156 YFDLTCQLLGKAEVD-----GASFLLKVWD-----GTRTp--FPSWRVLIQDl----VLEGD----------LSHIHRLQ 209 human
NP_996875    305 FFDLTCQLVGKAKVD-----GSSFLLKVWD-----GTKCp--YPTWKVPVEAk----ELEGD----------RVLLHHLR 358 chicken
AAO34129     167 FFDLLCQLVGKAEVD-----NSSYLIKVWD-----GTKIs--SPSWNVFVEEa----ALEGD----------QALIHQRQ 220 African clawed ...
XP_785462    132 YFDLICQVVAVVIIPa----ESCVLIKVWD-----GTKYk--WPVRCLDVSKv----QVKWD----------TELACRAE 186 purple urchin
CAG01067     153 FFDLTCQLLAKASMD-----SSCTLLRVWD-----GSRCp--HPQLKVDIGPd----VTEGP----------WSFSAQKE 206 Tetraodon nigro...
NP_740895     27 YFDVLAQVHSVVETK-----NGSWTLRVWR-----AQKFg--PEASKEKREMnl-fhVTENTfkcyivppdpRIGKAVEE 93  nematode
AAX24606      38 PQNRLCQLLPYSQHDphltaLTGHNLQQWNesilkDSKTyteENLHKVLEPNfa-stFLETF----------REDKNCHE 106 Schistosoma jap...
XP_001211512 196 FVDLVCEIIKVDTRD-----SYKTLAYVTD-----YTSN---RKLRAYASEDd---vGLEGDqy------nyQSWKTTWP 253 Aspergillus ter...
CAE74497      27 YYNIVAQVHSVVLTA-----RNIYVLRVWR-----GSSFg--PEHLKEKREAgmfhiNEEMFgsyiv-ppdnQILKVIER 93  Caenorhabditis ...

Feature 1                    ##                    # #                                        ## 
1XJV_A       210 n----LTIDILVYDN--HVHVARSLKVGSFLRIYSLHTKLQSMnse------nqtMLSLEFHL--------------HGG 263 human
NP_996875    359 n----LTVDVLVYDN--HVQLAKSLKTGSFLRIYSIHTKQASAkne-------dmSSHIEFHL--------------HGG 411 chicken
AAO34129     221 s----LIIDVLVYDN--HVESAKSLKIGSYLLIHNVHAKLHTSgken-----eakNPHMEFHL--------------HGG 275 African clawed ...
XP_785462    187 g----LILDVALYDN--HMKAGRELKPGDFVRLYNLHAASYIPpntap--tnqdnNDTDMIELe-------------NGR 245 purple urchin
CAG01067     207 q----LIANILVFDN--HVELAKELKPGDFLRIYNLRAIPGSHrlpglsssqpaeLHHLAFHL--------------HGG 266 Tetraodon nigro...
NP_740895     94 sg-keFLIEIDVYDD--HRIGIEKLNSGDFVALQNVHAASVGLt----------eMQVLHGGGqaynrgiskvpvdfRNE 160 nematode
AAX24606     107 mf-tdWSVPIYIYDEhtINEPVISLKPGDLIRIHNVHVSYGREk-----------HDHLTNLRli----------lhGSG 164 Schistosoma jap...
XP_001211512 254 gpsgqMTLPVLLWEP--HASYARDLLKGEFVQLTNVRIKEYDSkfegv---ihtdNDNIHIELvdaa-------sndRAK 321 Aspergillus ter...
CAE74497      94 fg-ksYLIEIVVYDN--HIETVKTLKSLDFVAIKNVHAFTRGD------------YLTMTLHG--------------GNG 144 Caenorhabditis ...

Feature 1         ## #     
1XJV_A       264 TSYGRGIRVL 273 human
NP_996875    412 TCYGRGIGIL 421 chicken
AAO34129     276 TCFGRGITVL 285 African clawed frog
XP_785462    246 AEYKEKPAIK 255 purple urchin
CAG01067     267 TAYGRGIRVL 276 Tetraodon nigroviridis
NP_740895    161 AFQIFKKRVE 170 nematode
AAX24606     165 HEFGRGVKYL 174 Schistosoma japonicum
XP_001211512 322 ELLRRKEMYW 331 Aspergillus terreus NIH2624
CAE74497     145 SFDRGIWVVP 154 Caenorhabditis briggsae

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