Conserved Protein Domain Family
hOBFC1_like
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cd04483: hOBFC1_like 
hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). The OB fold domain of RPA2 has dual roles in ssDNA binding and trimerization.
Links
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Statistics
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PSSM-Id: 239929
Aligned: 8 rows
Threshold Bit Score: 103.667
Created: 25-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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generic bindinggeneric binding
Feature 1:generic binding surface I
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###         #### #     ### #                                              #
Q9H668        58 DVLGTVIGVrerd-afySYGVDDSTGVINCICWKklntesvsaapsaarels------ltsqlkklqetieqktkIEIGD 130 human
NP_001004908  55 DVLGTVVFVreke-nfySYGVDDSTGVISCTCWKstaptevsspgtsarhvsss-skdldvmmrelykeeskkakLDIGD 132 western clawed ...
AAH53298      59 DVLGIVVYKrere-dfyCYGVDDSTGVINCLCWKdekwrdqggsttcgdasgfprsfniedelkglkeaelkstvLEIGD 137 zebrafish
BAF12095      40 EIVGVVVSRdrre-kflRFLVDDGTGCVPCVLWLnhhylnaassssras-----------dsdptaemalrmsevVSLGT 107 Japanese rice
NP_563781     42 EIVGTIVSRdltp-kflKFGVDDGTGCVTCVMWLnqltssyfsrwdpat------------illlasaarkqaaqIRIGA 108 thale cress
NP_585792    102 QIIGWVVSSktsa-tgsMFVLEDGTGSVDCTFWPgnsyee------------------------------eqckvLEEQN 150 Encephalitozoon...
CAL51547      80 EVCGYVVERrtrkdskvIFTLDDGTGCVECVVWMqdgdaatgersdlfg------------iasaadgaaalakeIRVGS 147 Ostreococcus tauri
BAE38722      65 DIMGAVISVkere-tfySYGVDDATGVINCVCWKklsnaesssgnca---------------chsplmslkvahqRAVSQ 128 house mouse

Feature 1                 ###                 ###       
Q9H668       131 TIRVR---GSIRTYRe-----------eREIHATTYYKV 155 human
NP_001004908 133 TIRVR---GSIKVFRd-----------qREIVASVFYKV 157 western clawed frog
AAH53298     138 LLRVR---GTVKTSRd-----------nREIKATSFYKV 162 zebrafish
BAF12095     108 LLRVR---GRIVLYRgaiqiavrdvvleKDPNVEVMHWL 143 Japanese rice
NP_563781    109 VARVR---GRVGSYRg-----------vMQITANVAVAE 133 thale cress
NP_585792    151 LLKVN---GSLRTFNg-----------kRSVSASHLSAV 175 Encephalitozoon cuniculi GB-M1
CAL51547     148 LARVQ---GVVRHWRg-----------hRQINTKSVQID 172 Ostreococcus tauri
BAE38722     129 CLHIKllpGCIGGPDtls--------lgGPETLSPVLWL 159 house mouse

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