Conserved Protein Domain Family
RPA1_DBD_B_like
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cd04481: RPA1_DBD_B_like 
RPA1_DBD_B_like: A subgroup of uncharacterized, plant OB folds with similarity to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). In addition to DBD-B, RPA1 contains three other OB folds: DBD-A, DBD-C, and RPA1N. The major DNA binding activity of RPA is associated with RPA1 DBD-A and DBD-B. RPA1 DBD-C is involved in trimerization. The ssDNA binding mechanism is believed to be multistep and to involve conformational change.
Links
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Statistics
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PSSM-Id: 239927
Aligned: 58 rows
Threshold Bit Score: 49.1965
Created: 22-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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generic bindinggeneric binding
Feature 1:generic binding surface I
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ###                       #### #           ### #                       #   
AAD15369   22 NYAGQIVMIGeledletn------nkptkkiDFEIRDem-----deRLAVTLWSSFAEHVfrscq------esdgkIVVY 84  thale cress
NP_187934 137 DAIGVIVKVYpirsfpfvcrqgetdyesryvAFKIKDnm-----gnAIKCVAIGKYCEEFvnkwftrtslitfnyePIVA 211 thale cress
NP_973455 127 DAIGVVASVSsikrfpyvcnkgetdyeakyvSFELIDnw-----eqKLKCVAVGSCCEEFvtkwsrritrptynyePVVC 201 thale cress
NP_973421 134 DAIGVITTVStvssfpyccpegesnyearyvTFTIRDnh-----erIITCVARGSVCESFlskfyqligskgynyePLTT 208 thale cress
NP_973422 137 DAMGVIESVSpigkipwvardwesdfasrylVFTLKDsm-----hkYIKCVAVGSSCEEFerkwykkisepnfkmePVMI 211 thale cress
NP_973420  97 DAMGIIKWVSnirrfpfvcrpretdyearyvKFTIADnv-----gnEVICIAVGQICDWFvnhwlkrinlitynyePIVV 171 thale cress
NP_189827 137 NVVGIISSVStfarfpyvyregetdyearyvKFTIRDn-------lITTCVAKGRACELFlikfyrriglvtynfePIVA 209 thale cress
NP_680300 137 NAVGVVSSVSsikrflyvcrqgetdyaaryvAVEIMDnw-----eqKIKCIVVGKCCELFvtnwfrrisrptynyePVVC 211 thale cress
AAF06082  130 NLNLCIIGNKktsavl----------lgnavNGLLRNgig----nkKFKCIAVGKCCEWFvnkwsrricrptynyePIVC 195 thale cress
NP_198324  34 DAMGVIESVSpigkipw-------varegesDFATRYlytsyyrhkYIKCVAVRSSCEEFerkwykkirepnfkmeHVMI 106 thale cress

Feature 1          ###               ###                               
AAD15369   85 LLrfSKIKAYng---------vRSLSNSf----DSSQVHVnpp--fpEVDVFVRSCK 126 thale cress
NP_187934 212 VLnfWRITNYhg---------sNVLMTVd----GISRLFIdpkfndiNIPSYIRGFS 255 thale cress
NP_973455 202 VVrfWRIASIdg---------eNVLTSEf----GCSRLHIdpsfpyfDLASYLRSFK 245 thale cress
NP_973421 209 VLrfFRTSMFkg---------sKALISEy----GCSRVFIe-----eNFSDFDVSCY 247 thale cress
NP_973422 212 ILrfWKISEFeg---------kPCLISVy----GCSKVHId-----pNFRGIDKNNY 250 thale cress
NP_973420 172 VLqnWRITNYhg---------nNVLMSDw----GFSKLYIdpkfeeiDIPTWLHGYM 215 thale cress
NP_189827 210 VVrfWRVHDFkg---------sNALFSEd----GCSKLLId-----pLFPDYDLQTY 248 thale cress
NP_680300 212 AVrfWRIAYVqg---------eNVLLSEp----GCSRLDId-----pSFPHFDLASY 250 thale cress
AAF06082  196 VVrfWRISELeg---------eNVLMSEf----GCSRLDIdprfpyfDLASYILQVT 239 thale cress
NP_198324 107 ILrfRKISEFegsddedddifmESVDSNlkyiqMMSMFLVsep--vkAIPVPTRRVN 161 thale cress

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