Conserved Protein Domain Family
RPA1_DBD_A_like
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cd04480: RPA1_DBD_A_like 
RPA1_DBD_A_like: A subgroup of uncharacterized plant OB folds with similarity to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). In addition to DBD-A, RPA1 contains three other OB folds: DBD-B, DBD-C, and RPA1N. The major DNA binding activity of RPA is associated with DBD-A and DBD-B of RPA1. RPA1 DBD-C is involved in trimerization. The ssDNA-binding mechanism is believed to be multistep and to involve conformational change.
Links
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Statistics
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PSSM-Id: 239926
Aligned: 58 rows
Threshold Bit Score: 57.262
Created: 22-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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generic bindinggeneric binding
Feature 1:generic binding surface I
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ###             #### #         ### #                 #       ###           
NP_189742  19 RVQVRVLHTWktftmqfgetfDMVLSDVRGk---KIHASVKreh-lnrFERPIVRG--EWRAIEnFGLTYatgqYKATDH 92  thale cress
AAD28056   18 AICVMVVRVYkkilnhdafelRLLLVDKLGt---QIEATIGprf-safYYDRIKEN--QWKTITtFIVRPnceaIRTTPH 91  thale cress
CAB78063   18 TICVFVVTVFkkfvapdefklGLILADQTGpr-sRIKATIPrrl-asfYFDRIREYeyEWIIITnFSVRNdaesVRATSH 95  thale cress
BAB02596   18 YVRLRVVRSLvvhlnalskivGLVLADEHGv---MVDAMIEkef-adyYNKFIDAG--DWITIMrFGVYPnlnpVRVTSH 91  thale cress
NP_180062  17 TICVMVLRKYvlfitdnsfelRVVFVDEWGi---QIEAIIGtrf-sqrYYDMLEEN--QWKEIRtFGVIEnwgfVRTTTH 90  thale cress
NP_189830  18 TLCVCLLRVYkklvypnsyeiCCILVDETGd---QMEATIDrry-aavYLESMQEK--ELKRLTtFIVRKiispIRSTSN 91  thale cress
NP_189862  18 RIYVFVVRVFknvispnvfelGLILADYAGsn-sRIEATVDrrl-apfYEDRFVEN--EWKTITsFLVRKatdsVRATKH 93  thale cress
NP_178740  18 TICVMILRIYkkmlndhsfelHLILQDEAGk---RIEVTIGtrf-safYYDRLIEN--QWKMIStFLGTVl--lNNFTPF 89  thale cress
NP_973422  18 FVFVKILRLWnwppnyfgeepTMILVDEKGh---RIDAKSSrhaykeeMISTLREG--KWYILSnFKVVVanplERFSTH 92  thale cress
NP_192491   1 MVYFHSLHELspfst-rwmicDMVLRVYIKehklRLHFTSPf------YFYMLQEN--QRKSIStFRVSPnfepIKATPH 71  thale cress

Feature 1       ###         
NP_189742  93 rYKMGFMa--QTHV 104 thale cress
AAD28056   92 eFRILFMe--QTVV 103 thale cress
CAB78063   96 dYQIWFMe--QTIV 107 thale cress
BAB02596   92 kFKICFFk--DTVV 103 thale cress
NP_180062  91 kYMIEFMn--ATEV 102 thale cress
NP_189830  92 lYGIWFMd--NTVV 103 thale cress
NP_189862  94 eYGILFMd--RTVV 105 thale cress
NP_178740  90 dYILEHSvrkDTLV 103 thale cress
NP_973422  93 vFQIEFLk--KTTM 104 thale cress
NP_192491  72 hYEIEFMe--ETLV 83  thale cress

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