2B3G,2B29,1EWI


Conserved Protein Domain Family
RPA1N
?
cd04477: RPA1N 
Click on image for an interactive view with Cn3D
RPA1N: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). RPA1N is known to specifically interact with the p53 tumor suppressor, DNA polymerase alpha, and transcription factors. In addition to RPA1N, RPA1 contains three other OB folds: ssDNA-binding domain (DBD)-A, DBD-B, and DBD-C.
Links
?
Statistics
?
PSSM-Id: 239923
Aligned: 36 rows
Threshold Bit Score: 87.638
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
binding surfacegeneric binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:binding surface I
Evidence:
  • Structure:2B3G_A; Human RPA1N binds P53n protein fragment; defined at 3.5A contacts.
  • Comment:RPA1 has four OB-fold domains: DBD-A, -B, -C, and an N-terminal RPA1N domain. RPA1N (also called RPA70N) participates in specific protein-protein interactions, DBD-A and -B are the principal DNA binding domains, and DBD-C interacts with RPA2 and RPA3.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 # #                 # #                             
2B3G_A     11 GAIAAIMQKgd-------tnIKPILQVINIRPIttgn------sppRYRLLMSDGLNTLsSFMLAtqLNPLVeeeqlsSN 77  human
BAC77529   12 GAVAFVLENaspdaatgvpvPEIVLQVVDLKPIg-----------tRFTFLASDGKDKI-KTMLLtqLAPEVrsgniqNL 79  Japanese rice
XP_446394   8 GDFVAIFTNqqry----qdpANGVYQVINIRKAdpsk------pnkKFLIMISDGVYHM-KALFKadAIPKLhsmnidRG 76  Candida glabrata C...
P22336      9 GDFHSIFTNkqry----dnpTGGVYQVYNTRKSdgan------snrKNLIMISDGIYHM-KALLRnqAASKFqsmelqRG 77  baker's yeast
AAS53364   61 GDLATIFKDrsry----enpVGGQYQCSQTKKAeqva------tskKNLILINDGVYHM-KALLRgdASQKAlthnlkRG 129 Ashbya gossypii AT...
XP_456619  10 GALKGILSKterq---sfegKPITVQVTNIKIIdqslengngdsavKYRVLLNDGAYSL-HGLITseCIPYCeangfkKT 85  Debaryomyces hanse...
XP_970093   8 GALLRIMKGqe--------vEEPLVQVLVSKKIssrs-----aeteRYRIWASDGDYSItYGILT--LPPGKpv---eDF 69  red flour beetle
NP_586175  57 GTVEALYNSqann----plyKNPVLQITSLGKLsvai-----gdkqRYRVNLSDGVNYM-KGIFSseLTPHFekglvsRY 126 Encephalitozoon cu...
XP_451388   8 GDLLDIFRIpery----nnpTGGIYQVVQTKKTetn--------akKNLILINDGKYHV-KALLRnkAAEAAqqaeleRG 74  Kluyveromyces lact...
NP_200908   8 DAISTVLSNpsfds--ssdrSEIVVQVVDLKPIg-----------nRYTFSANDGKTKV-KAMFTasLTPEIisgkiqNL 73  thale cress

Feature 1                        #                  
2B3G_A     78 CVCQIHRFIVNTLkd---gRRVVILM------ELEVLK 106 human
BAC77529   80 GVIRVLDYTCNTIge--kqEKVLIIT------KLEVVF 109 Japanese rice
XP_446394  77 DIIKTLRVEPLLIke---kKLVLVIE------DFDMVQ 105 Candida glabrata CBS 138
P22336     78 DIIRVIIAEPAIVre---rKKYVLLVd-----DFELVQ 107 baker's yeast
AAS53364  130 DIFRVLTGEPAVIke---kKKFVLIId-----DFEITQ 159 Ashbya gossypii ATCC 10895
XP_456619  86 SVIIIKDYSLVTTq-----KHIMIIN------NLEVKF 112 Debaryomyces hansenii CBS767
XP_970093  70 SIIKLKKFVKSEIsnakgpQKILLII------DSEIVT 101 red flour beetle
NP_586175 127 SLIRPGRFSVRSKd----gSVYIYIQeiqayeDCNVEI 160 Encephalitozoon cuniculi GB-M1
XP_451388  75 DVFKVLNAECAVIke---kKKFVLLVd-----EIEIVS 104 Kluyveromyces lactis NRRL Y-1140
NP_200908  74 GLIRLIDFTVNDIss--ksTKYFLVT------KCEAVG 103 thale cress

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap