1UEB,1UEB,1KHI,1X6O,2EIF


Conserved Protein Domain Family
S1_EF_like
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cd04463: S1_EF_like 
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S1_EF_like: EF-like, S1-like RNA-binding domain. The EF-like superfamily contains the bacterial translation elongation factor P and its archeal and eukaryotic homologs, aIF5A and eIF5A. All proteins in this superfamily contain an S1 domain, which binds RNA or single-stranded DNA and often interacts with the ribosome. Hex-1, the SI-like domain of which is also found in this group, is structurally homologous to eIF5A and might have evolved from an ancestral eIF5A through gene duplication.
Links
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Statistics
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PSSM-Id: 239910
Aligned: 5 rows
Threshold Bit Score: 54.9352
Created: 14-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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RNA binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:possible RNA binding site based on comparison with E. coli CspA.
  • Citation:PMID 9753699
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #                                #      ##   
1UEB_A     68 RELQYLYPEg----------eEMVFMDLet-yEQFAVPrsrvvg---------aeffkeGMTALGDMYe--GQPIKV 122 Thermus thermophilus
1UEB_A    128 VELKVVDTPpgvrgdtvsggsKPATLETg---AVVQVPlfv----------------epGEVIKVDTRt--GEYVGR 183 Thermus thermophilus
1KHI_A    104 KQYRVLDMQd----------gSIVAMTEt--gDVKQNLpvidqsslwnrlqkafesgrgSVRVLVVSDh--GREMAV 166 Neurospora crassa
1X6O_A     98 YTYSVLDIQanedp---slpaHLSLMDDegesREDLDMppdpalat-----qikeqfdsGKDVLVVVVsamGTEQVL 166 Leishmania braziliensis
2EIF_A     78 RKGQVLAIMg----------dMVQIMDLqt-yETLELPipegi-----------eglepGGEVEYIEAv--GQYKIT 130 Methanococcus jannaschii

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