1HR0,1ZO1,1AH9


Conserved Protein Domain Family
S1_IF1
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cd04451: S1_IF1 
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S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the formation of the first peptide bond. In Escherichia coli, the initiation mechanism requires, in addition to mRNA, fMet-tRNA, and ribosomal subunits, the presence of three additional proteins (initiation factors IF1, IF2, and IF3) and at least one GTP molecule. The three initiation factors influence both the kinetics and the stability of ternary complex formation. IF1 is the smallest of the three factors. IF1 enhances the rate of 70S ribosome subunit association and dissociation and the interaction of 30S ribosomal subunit with IF2 and IF3. It stimulates 30S complex formation. In addition, by binding to the A-site of the 30S ribosomal subunit, IF1 may contribute to the fidelity of the selection of the initiation site of the mRNA.
Links
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Statistics
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PSSM-Id: 239898
Aligned: 46 rows
Threshold Bit Score: 84.4946
Created: 13-Jun-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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rRNA bindingpredicted 30S
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:rRNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1HR0_W; Thermus thermophilus IF1 binds 16S rRNA. Contacts determined at 3.5Angstrom distance
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               ###     #             #  ##    ####                # #    
1HR0_W        7 IRTEGVVTEALpnaTFRVKLDSg--PEILAYISGKMRMHYIRILPGDRVVVEITPYDPTRGRIVYR 70  Escherichia coli
AAA16203     25 IKMTGKVTKMHstkNYDVLLENd--QEIKAYISGKMSLHNIKLIPGDMVDVEISPFNLTLGRIVFR 88  agent of mouse pneumonitis
585300       25 IKMTGKVTKMHstkNYDVLLENd--QEIKAYISGKMSLHNIKLIPGDMVDVEISPFNLTLGRIVFR 88  Mycoplasma sp.
NP_072836     6 LFLTGKILEIIhgdKYRVMLENn--VEVDAHLAGKMKMKRTKILPGDVVEVEFSPYDLKLGRITQR 69  Mycoplasma genitalium G37
NP_326396     6 IKMQAKVLKMFstdKYELELLEn-kVIIKGHISGKMRIHKIRILPGDIVDVEISPHDLSNGRITYR 70  Mycoplasma pulmonis UAB CTIP
AAT27743      6 IKMTGKVIKAYntdEYDVELENg--IVVRAHISGKIRVHHITILRGDTVDVELSTYDLTKGRIVYR 69  Mycoplasma mobile 163K
Q601J2       10 LLFQGKVTHVFnaqEYEVTLENg--IKLNCHIAGKMKIHHIKIIIGDMVKVEISPYDLSKGRIVYR 73  Mycoplasma hyopneumoniae 232
XP_766118    66 IIRSGVVVSCMpnaNFLVKLDVs-nRELPCSLAGKLYINMVRIWNNSKVNVEIDLERPTTGRIIER 130 Theileria parva strain Muguga
AAZ43985      6 IKLRAKVLEAYsmdDYLVELENk--QQIKAKISGKMRVNRIRILPGDLVDVELSSYDLTKGRITYR 69  Mycoplasma synoviae 53
ZP_01083917   2 IETSGVIEKEQgngFYLVTLDQpsgHQCLCRAAGKLTKFRIKLLAGDKVLVEISPYDLTRGRITYR 67  Synechococcus sp. WH 5701

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