1UHW,1W4M,2CSO


Conserved Protein Domain Family
DEP_PLEK1
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cd04445: DEP_PLEK1 
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DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, mainly by protein kinase C. Pleckstrin-like proteins contain a central DEP domain, flanked by 2 PH (pleckstrin homology) domains.
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Statistics
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PSSM-Id: 239892
Aligned: 6 rows
Threshold Bit Score: 187.367
Created: 18-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1UHW_A     7 GLGALYLSMKDPEKGIKELNLEKDKKVFNHCLTGSGVIDWLVSNKLVRNRQEGLMISASLLSEGYLQPAGDLSKNAADGI 86  house mouse
1W4M_A     5 DLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMIASSLLNEGYLQPAGDMSKSAVDGT 84  human
2CSO_A    17 DLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMIASSLLNEGYLQPAGDMSKSAVDGT 96  human
4927267  127 NLSALYLSMKDPEKGIKELKLEKDKKVFNHCFTGTAVIDWLVSSNSIRNRKEGLMLASSLLNEGYLQPAGDTSKAAAEGL 206 chicken
AAH59327 126 NLSQLYHSMKDPDRGIKDLNLEKDKKVFNHCFTGTCVVDWLVANHSVRNRQEGLMLASALLNEGHLQPAGDISKNAAQGL 205 African clawed frog
AAH61706 125 NLSELYVCMKDPDRGVKELKLEKDKRLFNHCFTGSTVIDWLISEEKSRNRTEAVMLASGLLNEGFLQPAGDTSKDGAEKG 204 zebrafish

1UHW_A    87 AENPFLDSPDAFYYFPDSG 105 house mouse
1W4M_A    85 AENPFLDNPDAFYYFPDSG 103 human
2CSO_A    97 AENPFLDNPDAFYYFPDSG 115 human
4927267  207 SDTPFLDLSDAYYYFPDSG 225 chicken
AAH59327 206 AETTLLDNSEALYYFPDSG 224 African clawed frog
AAH61706 205 AESVFLDQTEAFYYFADSG 223 zebrafish
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