Conserved Protein Domain Family
DEP_fRom2
?
cd04435: DEP_fRom2 
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) Rom2-like proteins. Rom2-like proteins share a common domain architecture, containing, beside the RhoGEF domain, a DEP, a PH (pleckstrin homology) and a CNH domain. Rom2, a yeast GEF for Rho1 and Rho2, is involved in mediating stress response via the Ras-cAMP pathway and also plays a role in mediating resistance to sphingolipid disturbances.
Links
?
Statistics
?
PSSM-Id: 239882
Aligned: 8 rows
Threshold Bit Score: 124.787
Created: 18-Sep-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
4539279    416 LLSRVASELLdrLQLGDITKDGLIYSNAFTGDHAVTVLMGIIht----------------sdRNLALLVGRSLDAQKFIH 479  fission yeast
1710635    420 LLSRVATKFKssIQLGEHKKDGLVYRDAFTGQQAVDVICAIIrt----------------sdRNLALLFGRSLDAQKLFH 483  baker's yeast
1710634    266 LLSLIAIKFKqtIKLSTHKKMGLLYRDSFTGKQAIDTLCLIIgs----------------ldRNLGMLIGKSLEAQKLFH 329  baker's yeast
XP_965808  377 LLSRVAETFRrkIVVGDRTKNELTYKNAFSGAEAVDVLSYIIrt----------------tdRNLALLLGRALDAQKFFH 440  Neurospora crass...
EAL19310   440 ILSMVSAAFKsyIPLADLTKDGITYKDSFSGQAAVTLIAELIkt----------------sdRNLALLLGRSLDAQKFFH 503  Cryptococcus neo...
XP_757179  629 LLSTVALLLRanVPRGVQIKGSIDYPNSFTGKDVVSTLQELLvsdavgsqhalvlsgdpsslRHVALSLAKSLKSQLFFH 708  Ustilago maydis 521
EAL17536   461 FLSEMALQLRdkVERQRHIKAGIAWVGSFTGRDIVTTIHNLLpphtr----------ekpndRRFALLLAQSLQNQLWFV 530  Cryptococcus neo...
EAU90429   304 LLSHIAVQLRdkIPRATHVKGGIPYDRAFTGKDVVSTIQGMIqrelain------hglstsdRRVAVQVARSLQSQLFFY 377  Coprinopsis cine...

4539279    480 DVTYd-HRLRDShrEIYQL 497  fission yeast
1710635    484 DVVYe-HRLRDSphEVYEF 501  baker's yeast
1710634    330 DVLYd-HGVRDSvlEIYEL 347  baker's yeast
XP_965808  441 DVTYe-HRLRDStyEMYQF 458  Neurospora crassa OR74A
EAL19310   504 DVTYd-HRLRDNpkEVYRF 521  Cryptococcus neoformans var. neoformans B-3501A
XP_757179  709 EVDWgeKELTDDvdEVYTF 727  Ustilago maydis 521
EAL17536   531 EVDWdiKPLRDSsdDVFRF 549  Cryptococcus neoformans var. neoformans B-3501A
EAU90429   378 EVEWggAVLQDGveDVYMF 396  Coprinopsis cinerea okayama7#130
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap