Conserved Protein Domain Family
NDPk7B
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cd04412: NDPk7B 
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.
Links
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Statistics
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PSSM-Id: 239875
Aligned: 21 rows
Threshold Bit Score: 150.092
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active sitemultimer
Feature 1:active site [active site]
Evidence:
  • Comment:NDKs possess the active site motif N-x-x-H-[GA]-S-D.
  • Comment:His residue is phosphorylated during catalysis
  • Citation:PMID 8747457
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                         #        #                   
Q9Y5B8     238 NCTCCIV--KPHAVSeg-lLGKILMAIRDa-GFEIsAMQMFnmDRVNVEEFYEVYKGvvtEYHDMVTEMYSg--PCVAME 311  human
EAA08318    89 QLSFGLI--KAEALLh---IGEILTKIHKa-GLGVrRLAMLk-IDENYSSMLKTVRSeasSLNYLMDCMPSq--SFVALE 159  Anopheles gambia...
EAT36846    91 QRTFVMI--FSEALQh---LGEILQAINKt-GLHIrQLKMLk-IDDNYSWILKNFRSensELCYFIDNIPSn--LFVAME 161  yellow fever mos...
XP_827400  195 NCSVCVI--KPHAIMsg-yQGAIIQRLIDe-GFHItALGMYslTVADAEDFLEVYNGvvpEYQRLVEQMSSg--PCWAVQ 268  Trypanosoma bruc...
XP_974333   98 QHTFGVI--KVSVIDk---IGEIFNQIQDr-HFEIiNVRMCrlKQAECLELYDHLRGs-aFLPFVVDHMTSg--PVVALQ 168  red flour beetle
EAR95639   235 NCTCCVI--KPHIVKqk-lSGKIIDIILSe-GYEIsAMQSFflDRPTSEEFLDLYKGvlpDFIQIVDHLASg--LSIALE 308  Tetrahymena ther...
AAX79911   206 NSTVVII--KPHALQkl-aGGVIVQQLIDa-GLEIsGISLTnmTSQQANELLKPYKG---VLPDFPDTMRSlmgTVWVLQ 278  Trypanosoma brucei
EAR89336  1177 QCTCCVI--KPHIVKqn-qVGEVIDMILSe-GFEIsALQTFflDRPTAEEFYEVYKGvlpEFNAIAEHLTSg--MCYALE 1250 Tetrahymena ther...
XP_814683  206 RCSVVIV--KPHAVQsh-aAGVILQQLVDt-GLELtALMLAnlSSRVVDNFLEPYKGv-lSDFGESAKALTg--LVWILQ 278  Trypanosoma cruz...
XP_769162  235 NNSVMLIqpKFKDYVghilVGLVNYISKIspDIYItGINTCipTANDLAEVMAAYQGvipRWSEYIDVFSTg--PCIALE 312  Giardia lamblia ...

Feature 1                      #     #              #         #  # ##       #     
Q9Y5B8     312 IQQn------nATKTFREFCGPADPeia-rhLRPGTLRAIFGktkiqNAVHCTDLpEDGLLEVQYFF 371  human
EAA08318   160 IIGn------nAYNQYRELCGPESIaea-kqCAPNSFRGLYG-----SDVYCSRSaDDAANVRTPRF 214  Anopheles gambiae str. PEST
EAT36846   162 LTGe------nSYTRFKALCGHANTadeanvSAPACLRALYG-----SGVYCPSSaSASDMESKFVF 217  yellow fever mosquito
XP_827400  269 VCAe------nSVSALRAICGPHDPdvc-hvLFPHTIRSKYGvdrtrNGVHCTDLeEDAPLESEFFF 328  Trypanosoma brucei TREU927
XP_974333  169 LVGd------nAIERWKANVGPTDPlea-rqTAPDTLRAIYGlekasNAFHAADNcDAVTKKLNLFF 228  red flour beetle
EAR95639   309 VRQe------nVVQNFRELCGPFDPqia-kqSKPNSIRAQFGidrvrNAVHCTDLqEDGLLELIYLL 368  Tetrahymena thermophila SB210
AAX79911   279 FVSlde--gvdVVSVAREVCGPFDPvia-keLRPTSIRARFGvdrahNAVHCCDLhEEGPLYSNFFF 342  Trypanosoma brucei
EAR89336  1251 VRQe------nAVKSFRDIAGPHDPeia-kvIRPNTIRARFGidrvkNGIHCTDLeDDGVLEITDTL 1310 Tetrahymena thermophila SB210
XP_814683  279 LVSldd--svdVVHLVREVCGPFDPafa-keLRPKSIRARFGvdranNAVHCCDLpEEGPIYTSFFF 342  Trypanosoma cruzi strain CL B...
XP_769162  313 VAThrppeevnMVETLRAFAGPFEPkia-tyLAPESVRAVYGtdainNCVFVTDLpEEAELHADFWF 378  Giardia lamblia ATCC 50803

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