1PBW


Conserved Protein Domain Family
RhoGAP_p85
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cd04388: RhoGAP_p85 
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RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.
Links
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Statistics
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PSSM-Id: 239853
Aligned: 5 rows
Threshold Bit Score: 236.694
Created: 14-Apr-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative GTPasecatalytic
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative GTPase interaction site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                          #                                   #   #  
1PBW_B     11 TLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSnlAELRQLLdcdtpsvdlemiDVHVLADAFKRYLLDL 90  human
AAL68953  113 TLPDLAEQFSPPDIGPPVLIKLIEAIEKKGLESATLYRSQSSSslTELRQILecdaasvdfeqfDIAILSDALKRYFLDL 192 African clawed frog
XP_424759 114 SLPDLTEQFSPPDVAPPILIKIIETIEKKGLECSTLYVTQSSSssAELRQILecdassldletfDVHTLSDALKRYLLDL 193 chicken
AAH80231  114 TLLDLTEQFAPPEVAPSMLLKLLEAIEKKGLDNPTLYRNFTAGggLDVRQCFdsdpasvdleqmDLQMLCDGLRRYLQDL 193 zebrafish
3914256   110 TLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAprTDWSLSDvd--------qwDTAALADGIKSFLLAL 181 human

Feature 1                                                                          #  ##      
1PBW_B     91 PNPVIPaAVYSEMISlapevqsseEYIQLLKKLIRspsIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLF 170 human
AAL68953  193 PHPVIPaLMYSEMLSaaresissdEYVQLLRKIIRcanVPQQYWLTLQYLLKHFFQLCQSSSKNLLSAKSLAEIFSPLLF 272 African clawed frog
XP_424759 194 PNPIIPaTVYSDIISvaqdvqsseEYAQLLKKLIRspnIPHQYWLTLQYLLKHFLRLCQASSKNLLNARSLAEIFSPLLF 273 chicken
AAH80231  194 PQPVIPpVIYNEMIRiaqevqgtdECAQHLRLVASstaLPPQYWLTLQSLLRHFSQVCQSSAVNLLSARALAEIFSPALF 273 zebrafish
3914256   182 PAPLVT-PEASAEARra-----lrEAAGPVGPALEpptLPLHRALTLRFLLQHLGRVARRAPALGPAVRALGATFGPLLL 255 human

Feature 1                              #                           
1PBW_B    171 Rfsaa------------ssdnTENLIKVIEILISTewne-rqpaPALPPKPPK 210 human
AAL68953  273 Riqvs------------ssdsSEFSTQILEVLIASewne-kqaaPALPPKPSK 312 African clawed frog
XP_424759 274 Kfqia------------ssdnAEHHIRILEILITSewne-rqpvPALPPKPPK 313 chicken
AAH80231  274 Rhqpts-----------cepsPEAHIRIIEVLVTSewsd-sqaaPALPPKPPK 314 zebrafish
3914256   256 RappppsspppggapdgsepsPDFPALLVEKLLQEhleeqevapPALPPKPPK 308 human

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