1O7F,2BYV,1UHW,1V3F,1FSH,1W4M,2CSO


Conserved Protein Domain Family
DEP
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cd04371: DEP 
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DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.
Links
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Statistics
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PSSM-Id: 239836
Aligned: 192 rows
Threshold Bit Score: 40.0165
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1O7F_A       196 KILRIAILsrap--hmirDRKYH---LKTYr-----QCCvGTELVDWMIQqtscvhsrTQAVGMWQVLLEDGVLNHvdq- 264 house mouse
XP_502966    161 DAVTQYYDsrvg--vrllEATRD---GHSI------YYFsGKAAWQWVMEccev-vsgLEILDILQEFLTAGFIERfdte 228 Yarrowia lipoly...
EAT87571     385 DSVHEFSTchvg--vkmaKNRKSa--SRPWe-----YSFnGRNAAQWLMDcssl-vdpSEAIEIGSLFLQLKLIAPvdpr 454 Phaeosphaeria n...
585141       417 DSLSDYSNglvg--vkmaRERKVg--DKICa-----NTFtGKAAVDWLMDcstt-iepRETVLIAELFVKYGLITVlqed 486 Emericella nidu...
XP_758251    197 DYPDAGVDrtlgievadiQEKVKgrgYRTVq-----HTFnSMSALDWLCDfttv-cgkDEAAEIMAHFQRLDLIHVvldk 270 Ustilago maydis...
AAF78951     212 FQRYNERSkgig--lvdvTERAQpllGKAQqq--hkYCFqAVHALEWLCDftsv-vgrEEAAEMAAQFVRFGLITLvsdk 286 Schizophyllum c...
XP_962532    444 DSLSDYRDgltg--vkmaAERKVn--GRTYr-----DTFtGKAATDWLMDcsta-vdrRETIEIASLFVEYELMEAvqqd 513 Neurospora cras...
XP_383773    198 GKKGHLSEgavg--irmqPERKIn--NRTYh-----DTFtGSSVAEWLRDnttc-vdlREAVNMATHFVHYNLIESvnad 267 Gibberella zeae...
EAU84287     205 RAKGIALHdvte--raqpLLGKG---QQVHk-----YCFhAVAALEWLCDftsv-vgrEEAAEMAAQFVRFGLITLvsdk 273 Coprinopsis cin...
XP_001384794 290 DSHVQYYVssvg--vrhfAFNVF---KTKGtevvlnNCLsGKAISQWLTDcsdi-lnpYHAKELGNLLLRYNLIEPilfp 363 Pichia stipitis...

1O7F_A       265 -------------------------erHFQDk-yLFYR 276 house mouse
XP_502966    229 sry-----------------seeakshTFVCsktAKYT 249 Yarrowia lipolytica CLIB122
EAT87571     455 -----------------------nsenNFQAvkhVIYY 469 Phaeosphaeria nodorum SN15
585141       487 rsmp----------------qvenslvAFQPsknAIYA 508 Emericella nidulans
XP_758251    271 skremepyddrdiiirvddrrggvtdgHYRChskTLYG 308 Ustilago maydis 521
AAF78951     287 rknndsaiiftvrgsapggnspvsqqgEFRCtskAIYK 324 Schizophyllum commune
XP_962532    514 kahm----------------qqnpghhLFQPtkhAIYQ 535 Neurospora crassa OR74A
XP_383773    268 lvym----------------nqfaackLFQPtpvAIYQ 289 Gibberella zeae PH-1
EAU84287     274 rkn-----------------ndsaiifTVRGs--APGG 292 Coprinopsis cinerea okayama7#130
XP_001384794 364 ps--------------------kscavRFIAdrdCFYS 381 Pichia stipitis CBS 6054
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