1E6I,2OSS,2OO1,1JSP,2R10,2R0V,1JM4,2E7O,2I7K,2D9E,2DAT,2R0Y,2R0S,2YQD,1EQF,2R10,2R0V,2R0Y,2R0S


Conserved Protein Domain Family
Bromodomain

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cd04369: Bromodomain 
Click on image for an interactive view with Cn3D
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99922
View PSSM: cd04369
Aligned: 278 rows
Threshold Bit Score: 46.5966
Threshold Setting Gi: 147787325
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:
  • Structure:1E6I: Bromodomain From Yeast GCN5 complexed with acetylated H4 peptide
    View structure with Cn3D
  • Structure:1JM4: NMR structure of human PCAF bromodomain in complex with HIV-1 tat peptide
    View structure with Cn3D
  • Structure:1JSP: NMR structure of human cbp bromodomain in complex with P53 peptide
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #                  #  #                          
1E6I_A         14 HDAAIQNILTELQnh-------aaAWPFLQPVnk--------------eeVPDYYDFIKEPMDLSTMEIKLEsn-----k 67   baker's yeast
CAN77990      300 SREEIDDLMGIFYsime----nenAPVFRGRHds--------------qrRARYKKLVRQHMDFDTIRSRINsh-----l 356  wine grape
NP_191357     271 IFVESQPLSDFIEilqs----hpiGSHFSRRLet--------------qeTSDYYRIIRQHIDFEMIRSRVEeg----yy 328  thale cress
2443880       253 SLALPKELMKIYNtiaq----necALVFRRRLds--------------qkRGRYKKLVRRHMDLDTVQSRINgc-----s 309  thale cress
CAB75926      299 AGDKSQPLIDIIKlirs----hprGSVFESRLrs--------------qdTKDYKRLIRQHLDMKTIEKKMEkg----sy 356  thale cress
AAO52648      287 YRPKVKTTKPILNel--------mIDHLKSMVlqlmkdtrtkqirepfgdQSKYKDHIKNPMDLGTIEKRLTtk-----y 353  Dictyostelium...
CAN75881      333 ICVKSQPLVSFLEiirs----hkhSSLFERRLet--------------qeTEVYKSIVRQHVDLESIQTKLDdg----ty 390  wine grape
EAR82104      751 PILKDDKLYDEYKnnlrq--qyrcTNYFQKFFtkne-----------fekIPNYLKLIKKPIDLYMMQRKAIsgd---yd 814  Tetrahymena t...
XP_769253     222 TTVAVTDLFLTYKradygdvlmkvELIRKLSLee--------------iqNVDKKSIIDWCYRIGAMAANKCdeerrpkp 287  Giardia lambl...
NP_001017969   78 ELQQGYRILGEFLqekhrgltapfLQPLGGVAtaeeevae---gprsggrGGRAFPQQPGQGMCLLQMEEKFas----gq 150  human
Feature 1                          #   #           #               
1E6I_A         68 YQKMEDFIYDARLVFNNCRMYNGen------tsYYKYANRLEKFFNNKV 110  baker's yeast
CAN77990      357 ITTSRELFRDLLLLANNALVFYSkk------srEHKSAVLLRDLVSRRL 399  wine grape
NP_191357     329 KTARTKFFRDLLLLINNVRVFYGep------spEFNAAKQLYQLIKKQM 371  thale cress
2443880       310 ISSAKELFRDFLLVANNAAIFYSkn------trEYKSAVGLRDIVTKSL 352  thale cress
CAB75926      357 VSSSLSFYRDLKLLFTNAIVFFPts------ssESIAAQELRTLVSNEM 399  thale cress
AAO52648      354 YKDYQIIYQDIKLVFSNVMEIVNaaiaandsndPMESVEELDKEFEEQY 402  Dictyostelium discoideum
CAN75881      391 SSSPRAFYRDLLLLFTNAIVFFPka------saEALAAGELRAMVLNEV 433  wine grape
EAR82104      815 NEPYEQLYKDFLLLIQNALNFNAhh------peAYREATKLNLLGRTAF 857  Tetrahymena thermophila SB210
XP_769253     288 YRSAQELLRDLLLIAFNARRYNSld------hfLHKMGGSMLADIRSAW 330  Giardia lamblia ATCC 50803
NP_001017969  151 YGGITEFVADFRLMLETCYRLHGvd------hwISKQGQKLEMMLEQKL 193  human

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