Conserved Protein Domain Family
ZnMc_ADAM_fungal
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cd04271: ZnMc_ADAM_fungal 
Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A Disintegrin And Metalloprotease) family of metalloproteases are integral membrane proteases acting on a variety of extracellular targets. They are involved in shedding soluble peptides or proteins from the cell surface. This subfamily contains fungal ADAMs, whose precise function has yet to be determined.
Links
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Statistics
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PSSM-Id: 239799
Aligned: 11 rows
Threshold Bit Score: 299.722
Created: 24-Jul-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Comment:Based on similarity to sequences with known structures.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
EAS36150   255 KVALIGVAADCEYTKSFnss---vqAAQRNIVNVVNSASQIYEEAFN-ITLGLRKVQVLPGECPATPPASAPWnaacgtr 330  Coccidioides imm...
XP_365884  334 RVALMGIATDCTYVKQFas----vaEARANIMTQVASASALYEKSFN-ISLAVRNLTISESCAAAPFSTENRWnqdc--- 405  Magnaporthe gris...
EAQ83790   220 PRALFGRQADTSGGNGAgralgsekAVTDNVLQLVNAASQLYESTFN-ISLALQNLTISDAGCPSTPPPSAPWnrpc--- 295  Chaetomium globo...
XP_503584  318 QIALIGAAADCNYMKDFns----teSVRANILANMNTISQLYEQSFNiSLGLKALVLANSTDCPTTAVDSAPWnyect-- 391  Yarrowia lipolyt...
AAW46245    28 QIVYMGVALDCNYVAAYgs----peRARIQTLNNWNQISSLYKSAFN-ISLGLIEIQVQDMACPKTVVEGEEWnigc--- 99   Cryptococcus neo...
BAE64489   251 RVALVGIATDCSYTSSFds----teSLRRSLINMVNAASEVFESSFN-ISLALHNLTISDANCPSTASDSAPWnvgc--- 322  Aspergillus oryzae
XP_391400  267 RVALIGIAADCSYTAEFds----veDARDNIVSIVNAASQVYEDTFN-IALAIKNLTLADPSCPSEASSATPWnlpc--- 338  Gibberella zeae ...
XP_758858  363 RVVYAGVASDCAYTERFgt----qdDTRREILNNMNSVSNLYRSTFN-VSIGVVELDVRSASCPSSATQDAPWnlgc--- 434  Ustilago maydis 521
AAX47072   280 QVALVGIAADCSFRASFdn----ddAAKQWIINMVNSASDVYEKSFN-ISIGLRNLTMTDKTCPETAPASTQWnmpc--- 351  Aspergillus fumi...
CAD21161   488 KVALIGIATDCTYTEKFns----teSLRQNVIDMVNKASQLFESSFS-ISLGIRNLTISDKECPATPPDSAPFnmpc--- 559  Neurospora crassa
O13766      65 QTLWIGVVADCSYVTHFts----rmEAKKHIFQEFEGVSTLYEDSFN-INVQIHSLILPSAHDCSANVVDRPEisms--- 136  Schizosaccharomy...

Feature 1                                                                                      
EAS36150   331 qnsgpDISRRLNLFSAWRGEQNd----DNAFWMLMTTCNSGPEVGLAWLGQVCintasrq------sdrdggpTQSVSST 400  Coccidioides imm...
XP_365884  406 -nanlDVSDRLSAFSAFRGNLRn---dRNAFWTLMSSCTSGSAVGIAWLGALCmpgtq----------tdsrgTTVAGAN 471  Magnaporthe gris...
EAQ83790   296 -ndgtDVDARLSLFSQWRGQWQd----TNAFWTLLSTCGSGPTVGLAWLGAVCqqgss-----------trgnETSASAN 359  Chaetomium globo...
XP_503584  392 atqpnAISDRLSAFSQWRGDRSs---dGIAAWTLFTDCAQGSTVGLSWLGVLCgaras-----------qqgnTWVAGTN 457  Yarrowia lipolyt...
AAW46245   100 -dhniSLDQRLSDFSGWRGQRGd---dGAGLWHLMTACPTESEVGVAWLGTLCrtdsa-----------dqagSMVSSTG 164  Cryptococcus neo...
BAE64489   323 --segDMNSRLQEFSSWRSSLSd---tENAYWTLMTGCPSGSEVGISWIGQLC--------------------SSQSSTN 377  Aspergillus oryzae
XP_391400  339 -termIINNRLNIFTRWRSGFRd----DNAVWSLFTACKKDTAVGVAWIGSLCnksqq----------stynrGSTASAN 403  Gibberella zeae ...
XP_758858  435 --gtiTIDERLSDFSRWRSQQPg---nGIGLWHLMTACNSGREIGVAWLGTVCmtdas-----------sssgQTVSGTG 498  Ustilago maydis 521
AAX47072   352 --dqsNITQRLNLFSQWRGQQSd----DNAYWTLMSNCPTGSEVGLAWLGQLCntevt-----------gdgsNSVSGTN 414  Aspergillus fumi...
CAD21161   560 -ssgaTITDRLVKFSEWRGKSNd----NNAYWTLLSTCNTGPAVGLAWLGQVCqpgat----------qsqgnETVAGAN 624  Neurospora crassa
O13766     137 --priSIEEKLEIFSKWKYESPgnnvfEAISPHERESFPSEPQVSVLFTSSVKrsphgvswfaticsethienEWHVGPL 214  Schizosaccharomy...

Feature 1                    ##  #     #                                                       
EAS36150   401 GVVVrtpqEWQVFAHEAGHIFGAVHDCdselcasq---anvararCCPLTADSCDADGRFIMNPtsgr--gitDFSPCTI 475  Coccidioides imm...
XP_365884  472 YVARtg-nEWQVLAHEIGHTFGAEHDCisstcsst---sgtgaqqCCPLSASQCDAQQRFIMNPsars--gitEFSRCTI 545  Magnaporthe gris...
EAQ83790   360 VVVRts-tEWLVFAHETGHTFGAVHDCdsrtcnd----gsvqrqeCCPLGTGTCDADAQFIMNPstgn--gitQFSPCSI 432  Chaetomium globo...
XP_503584  458 VVAKts-lEWKVWAHELGHIFGAVHDCtsqtcsd----gtvdkndCCPMSTSACNANGQWIMNPasgq--qetTFSECTK 530  Yarrowia lipolyt...
AAW46245   165 VSTAtr-tEWSLIAHEIGHGFGAIHDCtsgcs---------lsgsCCPLTTTTCNASGRYIMNPttss--tehFFSGCTV 232  Cryptococcus neo...
BAE64489   378 VVAQts-nQWQVFAHESGHTFGAVHDCdsstc--------ssstqCCPLSSSTCDADAQYIMNPysms--sqtEFSPCTV 446  Aspergillus oryzae
XP_391400  404 VIVHta-lEWQVFAHELGHNFGASHDCtstecrn----grsssdnCCPLSRSTCDAGNQYLMNPhasr--gieEFSPCTI 476  Gibberella zeae ...
XP_758858  499 VSSLtt-qQWQVMAHEMGHNFGAIHDCtngctsnsnfavqnggapCCPLSATTCNANAQYIMNPssss--niqSFSQCSI 575  Ustilago maydis 521
AAX47072   415 VVVRvsggGWQVFAHESGHTFGAVHDCdsmtcaq----nleassqCCPYNRGTCDANGKYIMNPstga--ditAFSPCTI 488  Aspergillus fumi...
CAD21161   625 VVVKts-tEWQVFAHESGHTFGAVHDClpdtcad----gsagenkCCPLSTTTCDANAQFIMNPstdd--ritSFSACSI 697  Neurospora crassa
O13766     215 SVVSaypnDRLVVAHEIGHILGLIHDCnkkscg-------dhseaCCPLSSSLCDAQELYIMNPsnsytyanlRFSDCSI 287  Schizosaccharomy...

Feature 1                            
EAS36150   476 GQICTAMGRni----vrTSCFT 493  Coccidioides immitis RS
XP_365884  546 GSVCSQLGVrpgstrslGRCLV 567  Magnaporthe grisea 70-15
EAQ83790   433 GNICSFLGRtp-----nRVCDP 449  Chaetomium globosum CBS 148.51
XP_503584  531 GNICAGIGRns----lnTSCLI 548  Yarrowia lipolytica CLIB122
AAW46245   233 GNVCSNIGNrg----ilTSCIQ 250  Cryptococcus neoformans var. neoformans JEC21
BAE64489   447 GNVCSLLGSrn----mrTSCLL 464  Aspergillus oryzae
XP_391400  477 GTICTAIKEed----idTSCLV 494  Gibberella zeae PH-1
XP_758858  576 GNICSLLGQgl-----dTSCIQ 592  Ustilago maydis 521
AAX47072   489 GNICSALGRns----vkSSCLS 506  Aspergillus fumigatus
CAD21161   698 GNICSFLGRnp----grLSCLS 715  Neurospora crassa
O13766     288 LQLHSLVEKky----vsLSCLS 305  Schizosaccharomyces pombe

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