Conserved Protein Domain Family
DUF619-NAGS-U

?
cd04265: DUF619-NAGS-U 
DUF619 domain of various N-acetylglutamate Synthases (NAGS) of the urea (U) cycle of humans and fish
This family includes the DUF619 domain of various N-acetylglutamate synthases (NAGS) of the urea cycle found in humans and fish, the DUF619 domain of the NAGS of the fungal arginine-biosynthetic pathway (FABP), as well as the DUF619 domain present in C-terminal of a NAG kinase-like domain in a limited number of predicted NAGSs found in bacteria and Dictyostelium. Ureogenic NAGS is a mitochondrial enzyme catalyzing the formation of NAG from acetylcoenzyme A and L-glutamate. NAGS is an essential allosteric activator of carbamylphosphate synthase I, the first and rate limiting enzyme of the urea cycle. Domain architecture of ureogenic and fungal NAGS consists of an N-terminal NAG kinase-like domain and a C-terminal DUF619 domain. The DUF619 domain function has yet to be characterized.
Statistics
?
PSSM-Id: 176267
View PSSM: cd04265
Aligned: 11 rows
Threshold Bit Score: 145.978
Threshold Setting Gi: 24215392
Created: 2-Dec-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
JC7912        405 DDYLASLrprLHSIYVSEg----YNAAAILTmepvlggtPYLDKFVVSs-------------------SRQGQGSGQMLW 461  human
XP_685919     390 EDYIASLegrLHSVYLSEg----YSAAAIITtepvnsgtPYLDKFVVSs-------------------SKQGQGTGQILW 446  zebrafish
XP_643952     981 TDYFDYLkdsLYRLYLCVssdgeYNGCAIVTfkep-dyiPYLCKFCVKk-------------------SAQGLGLGDLVW 1040 Dictyostelium...
ZP_00682951   321 PHYFETTp--LLRAYVSEn----YRAAVILTklg---nvPYLDKFAVLd-------------------DAQGEGLGRAVW 372  Xylella fasti...
CAG02091      381 RDYIDSLqgrVHAVYLSEg----YNAAAIITmepvnngtPYLDKFVVSs-------------------SKQGQGTSHLLW 437  Tetraodon nig...
NP_712873     254 KDFWNQK---FAGILLESe----FKGCALVKnts---fgTFLSKFAVDe-------------------IARGEGVGRDIW 304  Leptospira in...
ZP_00952756   331 PGYFDAMa--FDHAFVTEn----YRAAAITTrld---dmVYLDKFAVLd-------------------EARGEGLGGAVW 382  Oceanicaulis ...
ZP_01018066   320 PGYLDNLq--VAKIYASAd----MRAAAVVIeve---gmAVLDKFAVSr-------------------GARGEGLSHALW 371  Parvularcula ...
XP_001625474  329 LDYFSKIerqLHTIYISEs----YSAAAIITvpkdtggvPYLDKFTVSk-------------------ESQGKGTSEKLW 385  starlet sea a...
XP_002598487  574 DDYWERLqgrLNTLYLSEg----YNAAAIVTneqv-dgmPYLDKFSVStqiqtdekararegeyyyqeQLEGQGTSEMLW 648  Florida lancelet
XP_796101     385 KNYILELprrLHTIYLSEg----YNAVAIITkendvhnvPYLDKFSISl-------------------QTQGEGTSEMLW 441  purple urchin
JC7912        462 ECLrrdlqTLFWRSRVTNpINPWYFKHSDGSFsnk--qwiFFWFG 504  human
XP_685919     447 ECIrqdfsKLFWRSRTTNrINPWYFKHCDGSFvng--hwiVFWLG 489  zebrafish
XP_643952    1041 RALqrdneKLYWRSRNSNpLNPWYFQRCQGSFrade-sftIFWYG 1084 Dictyostelium discoideum AX4
ZP_00682951   373 SIMreetpQLFWRSRHNNqANAFYYAESDGYYkqd--hwkIFWNG 415  Xylella fastidiosa Ann-1
CAG02091      438 ECIrqdlgKLFWRSRATNrINPWYFKHSDGSFvngvwnrlLVWPK 482  Tetraodon nigroviridis
NP_712873     305 DELiyrfpILFWRARKENtISKWYMKVCDGMQkeg--iwiYFWIG 347  Leptospira interrogans serovar Lai str. 56601
ZP_00952756   383 RRLieyapKLYWRSRSNNpVNEFYFSTCQGAVksg--pwtVFWRG 425  Oceanicaulis alexandrii HTCC2633
ZP_01018066   372 RRMsedfpLLFWRSRAQNgFNAFYSERADGCVrrg--mwqVFWQG 414  Parvularcula bermudensis HTCC2503
XP_001625474  386 KKItkdfeKLFWRSRGTNrINPWYFMRSNGSWtng--lwtVFWYG 428  starlet sea anemone
XP_002598487  649 EHVrrdfkSLFWRSRGSNkINPWYFKRSEGSWsdg--qwtVFWYG 691  Florida lancelet
XP_796101     442 DYLrrdfgMLFWRSRSIS-SDVKGSWSNSKWT--------VFWYG 477  purple urchin
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap