Conserved Protein Domain Family
DUF619-NAGS

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cd04264: DUF619-NAGS 
DUF619 domain of various N-acetylglutamate Synthases of the fungal arginine-biosynthetic pathway and urea cycle found in humans and fish
DUF619-NAGS: This family includes the DUF619 domain of various N-acetylglutamate synthases (NAGS) of the urea cycle found in humans and fish, the DUF619 domain of the NAGS of the fungal arginine-biosynthetic pathway (FABP), as well as the DUF619 domain present in C-terminal of a NAG kinase-like domain in a limited number of predicted NAGSs found in bacteria and Dictyostelium. Ureogenic NAGS is a mitochondrial enzyme catalyzing the formation of NAG from acetylcoenzyme A and L-glutamate. NAGS is an essential allosteric activator of carbamylphosphate synthase I, the first and rate limiting enzyme of the urea cycle. Domain architecture of ureogenic and fungal NAGS consists of an N-terminal NAG kinase-like domain and a C-terminal DUF619 domain. The DUF619 domain function has yet to be characterized.
Statistics
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PSSM-Id: 176266
View PSSM: cd04264
Aligned: 13 rows
Threshold Bit Score: 130.178
Threshold Setting Gi: 498995
Created: 2-Dec-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAA84051      423 HDYIKRIn-gKIATIIVIg---dYEGIAILTyegse---ensfVYLDKFAVLphlk------------------gslGIS 477  baker's yeast
JC7912        405 DDYLASLrprLHSIYVSEg----YNAAAILTmepv----lggtPYLDKFVVSssr-------------------qgqGSG 457  human
XP_685919     390 EDYIASLegrLHSVYLSEg----YSAAAIITtepv----nsgtPYLDKFVVSssk-------------------qgqGTG 442  zebrafish
XP_643952     981 TDYFDYLkdsLYRLYLCVssdgeYNGCAIVTfkep-----dyiPYLCKFCVKksa-------------------qglGLG 1036 Dictyostelium...
ZP_00682951   321 PHYFETTp--LLRAYVSEn----YRAAVILTklg-------nvPYLDKFAVLdda-------------------qgeGLG 368  Xylella fasti...
CAG02091      381 RDYIDSLqgrVHAVYLSEg----YNAAAIITmepv----nngtPYLDKFVVSssk-------------------qgqGTS 433  Tetraodon nig...
NP_712873     254 KDFWNQK---FAGILLESe----FKGCALVKnts-------fgTFLSKFAVDeia-------------------rgeGVG 300  Leptospira in...
ZP_00952756   331 PGYFDAMa--FDHAFVTEn----YRAAAITTrld-------dmVYLDKFAVLdea-------------------rgeGLG 378  Oceanicaulis ...
ZP_01018066   320 PGYLDNLq--VAKIYASAd----MRAAAVVIeve-------gmAVLDKFAVSrga-------------------rgeGLS 367  Parvularcula ...
XP_001625474  329 LDYFSKIerqLHTIYISEs----YSAAAIITvpkd----tggvPYLDKFTVSkes-------------------qgkGTS 381  starlet sea a...
XP_002598487  574 DDYWERLqgrLNTLYLSEg----YNAAAIVTneqv-----dgmPYLDKFSVStqiqtdekararegeyyyqeqlegqGTS 644  Florida lancelet
XP_796101     385 KNYILELprrLHTIYLSEg----YNAVAIITkend----vhnvPYLDKFSISlqt-------------------qgeGTS 437  purple urchin
CAA22186      367 DAYLDRLk-nSLAAVIIAg---dYLGTAIVTyeqpdgttnekvPYLDKLAVSqgaq------------------gsaAIS 424  fission yeast
CAA84051      478 DIIFNLMfkkfpnEILWRSRKDNvvNKWYFQRSVAVLdlsidldpehcdekqsqfkLFYYG 538  baker's yeast
JC7912        458 QMLWECLrrd-lqTLFWRSRVTNpiNPWYFKHSDGSFsnk-------------qwiFFWFG 504  human
XP_685919     443 QILWECIrqd-fsKLFWRSRTTNriNPWYFKHCDGSFvng-------------hwiVFWLG 489  zebrafish
XP_643952    1037 DLVWRALqrd-neKLYWRSRNSNplNPWYFQRCQGSFrade------------sftIFWYG 1084 Dictyostelium discoideum AX4
ZP_00682951   369 RAVWSIMree-tpQLFWRSRHNNqaNAFYYAESDGYYkqd-------------hwkIFWNG 415  Xylella fastidiosa Ann-1
CAG02091      434 HLLWECIrqd-lgKLFWRSRATNriNPWYFKHSDGSFvngv-----------wnrlLVWPK 482  Tetraodon nigroviridis
NP_712873     301 RDIWDELiyr-fpILFWRARKENtiSKWYMKVCDGMQkeg-------------iwiYFWIG 347  Leptospira interrogans serovar L...
ZP_00952756   379 GAVWRRLiey-apKLYWRSRSNNpvNEFYFSTCQGAVksg-------------pwtVFWRG 425  Oceanicaulis alexandrii HTCC2633
ZP_01018066   368 HALWRRMsed-fpLLFWRSRAQNgfNAFYSERADGCVrrg-------------mwqVFWQG 414  Parvularcula bermudensis HTCC2503
XP_001625474  382 EKLWKKItkd-feKLFWRSRGTNriNPWYFMRSNGSWtng-------------lwtVFWYG 428  starlet sea anemone
XP_002598487  645 EMLWEHVrrd-fkSLFWRSRGSNkiNPWYFKRSEGSWsdg-------------qwtVFWYG 691  Florida lancelet
XP_796101     438 EMLWDYLrrd-fgMLFWRSRSISs-DVKGSWSNSKWT-------------------VFWYG 477  purple urchin
CAA22186      425 DVMFNVMtdlfpkELIWRSRLTNpvNKWYFERSVGSLkssk-----------tpwkLFWTG 474  fission yeast
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