Conserved Protein Domain Family
AAK_AK-DapDC
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cd04259: AAK_AK-DapDC 
AAK_AK-DapDC: Amino Acid Kinase Superfamily (AAK), AK-DapDC; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the bifunctional enzyme AK - DAP decarboxylase (DapDC) found in some bacteria. Aspartokinase is the first enzyme in the aspartate metabolic pathway, catalyzes the conversion of aspartate and ATP to aspartylphosphate and ADP. DapDC, which is the lysA gene product, catalyzes the decarboxylation of DAP to lysine.
Links
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Statistics
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PSSM-Id: 239792
Aligned: 4 rows
Threshold Bit Score: 486.275
Created: 23-Jun-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative catalytic residues [active site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #                                          #                                
AAM37756     10 WIVLKFGGTSVSRrhRWDTIGKLASkran--etggRVLVVVSALSgVTNELTAIAdgaadsaqrv-----aaldqrhref 82  Xanthomonas axon...
YP_444447     9 WVVCKFGGTSVSSraRWDTIVEVVRthra---egrAPFLVCSALQgISDQLEALCaqlasaepgapestlntirerhral 85  Salinibacter rub...
ZP_00952864  12 WTVLKFGGTSVAKpeNWAVIAKLAKarlkqdkpggKVLIVHSALSgVSNRLEALPdqallgdvsse---iaaikavhldf 88  Oceanicaulis ale...
YP_124092     9 QVVIKFGGTSVSSraTWNNIAAITQkhln---tgvQPVIVCSALTqISNKLEKAIeaalldehhsl---fndiqsshlnl 82  Legionella pneum...

Feature 1                                                   #                                   
AAM37756     83 LAELEldadavLGERLAALHALLgdaraat-rtldwqaEVLGQGELLSSTIGAAYLhasgLDMGWLDarqWLSALPPQPN 161 Xanthomonas axon...
YP_444447    86 GQDLGveaeavLSGEFARLERWVdeiqatdgpsprqraAVLATGELLSTRLGAAYLsaqgLPAEWLDareFLRATDDPHL 165 Salinibacter rub...
ZP_00952864  89 AEAALldgstlLVSHFETLDRLAagialvreasprvraELLALGEQMASVLGMERLrqegLSPVFLDardALQAASNSED 168 Oceanicaulis ale...
YP_124092    83 AEQLEvnh-qlIANDLHQLQQWLtgisllkqapakthaQILSLGELMMTRLGHAFLekqgIKVKWYDareLLTSTPTLGG 161 Legionella pneum...

Feature 1                                                             #                         
AAM37756    162 QSEWSkrlsvscqwqsdADWRTRFAaqptRLLITQGFISRHadGGTAILGRGGSDTSAAYFGALLGASrVEIWTDVPGMF 241 Xanthomonas axon...
YP_444447   166 PPRRQylaanc-tshadPGLQARLAdapeTVYLTQGFIASNalDETVLLGRGGSDTSAAHFAAKLEAErTEVWTDVPGLF 244 Salinibacter rub...
ZP_00952864 169 AGGYLsnsvi---egadARLQMRLKd--aELVLTQGFIARNsrDETVLLGRGGSDTSAAYFANKLDAAkLEIWTDVPGLF 243 Oceanicaulis ale...
YP_124092   162 ETMNYlsarce-seydpALVEKFLStg-aQAIITQGFFAANphGETVLLGRGGSDTSAALLAGKLQAAsCEIWTDVPGIY 239 Legionella pneum...

Feature 1                          #            #                              
AAM37756    242 SANPKEVpdarLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDsgVPMAILDTERPdlpGTSID 304 Xanthomonas axonopodis pv. citri ...
YP_444447   245 TANPGEVpsgrLLRRLDYDEAQELATMGARVLHPRCLDPARRhqIPLHVRSTEAPsldGTIVS 307 Salinibacter ruber DSM 13855
ZP_00952864 244 SADPRLTegarLLQALSYDEAQEIATMGGKVLHPRCIGPARRanVPVEVRSTLRPelaGTLIT 306 Oceanicaulis alexandrii HTCC2633
YP_124092   240 TANPHQLpharLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKanIPMVVKYTHLPehsGTLIT 302 Legionella pneumophila str. Paris

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