2J0W


Conserved Protein Domain Family
AAK_AKiii-LysC-EC

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cd04258: AAK_AKiii-LysC-EC 
Click on image for an interactive view with Cn3D
AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some bacteria such as E. coli. Aspartokinase is the first enzyme in the aspartate metabolic pathway and catalyzes the conversion of aspartate and ATP to aspartylphosphate and ADP. In E. coli, LysC is reported to be a homodimer of 50 kD subunits.
Statistics
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PSSM-Id: 239791
Aligned: 9 rows
Threshold Bit Score: 416.38
Created: 23-Jun-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:putative catalytic residues [active site]
Evidence:
  • Comment:based on similarity to mutational studies of Escherichia coli AKIII.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #                                                                           
2J0W_A        4 IVVSKFGGTSVADfdAMNRSADIVLsd--anVRLVVLSASAgITNLLVALAeglepgerfek----ldairniqfaiLER 77  Escherichia coli
ZP_01042746   8 FRVAKFGGTSVANysAICAAVANVKsq--nqPILVVVSACAgVTDRLVMLAnesdnvesilseivhrhteiadelsrLNR 85  Idiomarina balti...
EAO67827      6 INVAKFGGTSVATyaTMLNCAKVVKgn--paTKVVVVSASAgVTNILVELAhkaltkdeisay---ieqiqaiefaiLND 80  Pseudoalteromona...
YP_155828     3 FTVAKFGGTSVADyaSMLRCAEIIQsn--ssIRLVVVSACAgVTNRLVAIAdlqgrqieklln--eiyeihfaiqkrLKN 78  Idiomarina loihi...
YP_268734    10 LTVAKFGGTSVADyqAMLRCANIIKnd--nsNRLVVVSASSgVTNLLVRLSqknvsvieqkdi---veniraiqvniTQH 84  Colwellia psychr...
NP_967151     4 LVVSKFGGTSMGDadCMLRSAEVSFrq---gSGLVVVSATSgTTNDLIALGktaesqawsesek-ilskiqdkhnkiAQD 79  Bdellovibrio bac...
NP_661001     1 MVVMKFGGTSVGSaaAMRQVIANVAekkkssAPLVVLSACSgITNKLIQIAdaagsgcleeaqq-lvgevrqfhldlIGE 79  Chlorobium tepid...
ZP_00519690   1 MIVMKFGGTSVESaaAIERVAGIVRare-arRPVVVVSAMGkTTNKLLAIAsaaiagkrneyip-qlhdlrdyhsreARL 78  Solibacter usita...
AAC76994      4 IVVSKFGGTSVADfdAMNRSADIVLsd--anVRLVVLSASAgITNLLVALAeglepgerfek----ldairniqfaiLER 77  Escherichia coli...
Feature 1                                                                                       
2J0W_A       78 LRypnv----ireeIERLLENITVLAeaaalat---spaltdELVSHGELMSTLLFVEILre------rdVQAQWFDvrk 144 Escherichia coli
ZP_01042746  86 AGavek-----qlaLDDLHDRLRQHVarrptphdasfvawrdQLLSFGEYCSSLLFSWAWeak-----teQPSAVLEakt 155 Idiomarina balti...
EAO67827     81 LGaptl----vadkLLELLESLKQLAfheeilh---rpdlkdSLLSHGERMASLLFSEVLtq------qgLPADNFDvrn 147 Pseudoalteromona...
YP_155828    79 ASqvq-------ksLEQLHHKLALHCqktted----qaswrdELLSFGERCSSLLFSSLLve------qgLCSSTLDarq 141 Idiomarina loihi...
YP_268734    85 LSsdvea--qlnqeINSLLDELTQHAltqllqy---stktadAILAFGEQFSSRIFAQVLqs------vdIPGEYFNvqq 153 Colwellia psychr...
NP_967151    80 LKlpad----akakLETLFEEMSSLAkgmhllkd-csvkamdTLMSLGERMSSVLFTEAMsqvlkkhgsaKSAELLDvrt 154 Bdellovibrio bac...
NP_661001    80 LIeseelqqeviakIEVYLTRLERLTegieivge-lterskdRFCSFGELLSTSVFAAALne------agVSCKWIDvrt 152 Chlorobium tepid...
ZP_00519690  79 VVplsera-eldrfLDEHFQELTELVkglavlge-ltprsidAISSYGERLSSYIVTLAFrh------fgMAAEHIDsrd 150 Solibacter usita...
AAC76994     78 LRypnv----ireeIERLLENITVLAeaaalat---spaltdELVSHGELMSTLLFVEILre------rdVQAQWFDvrk 144 Escherichia coli...
Feature 1                                                                 #                     
2J0W_A      145 VMRTNDRFGRAEPDIaalaELAALQLLPRLNe-GLVITQGFIGSENkGRTTTLGRGGSDYTAALLAEALHASrVDIWTDV 223 Escherichia coli
ZP_01042746 156 WLFTDSRYGRARPQLkamiEKAPQWLKTLEPg-RLYVTQGFIGKNErGQTTTLGRGGSDYSAALLAVVVQAQeLQIWTDV 234 Idiomarina balti...
EAO67827    148 VLLTDSEFGQAAPQLdgikQRAAKLMAPEIAk-TVLVTQGFIGSDEaGNTTTLGRGGSDFTAALLAEALGAQsCEIWTDV 226 Pseudoalteromona...
YP_155828   142 LLKTNSDFGRAQPDEvt-tKSHCLEQKQKLEsgCVRVTQGFIGSDEnNQTTTLGRGGSDYSAALLAAGFNATdLQIWTDV 220 Idiomarina loihi...
YP_268734   154 VMKTNSLYGKAVVDLnqlsEQSTQLLAPKLId-KVIVTQGFIGQDSqGHTTTLGRGGSDYSAALLAEALNGTnLSIWTDV 232 Colwellia psychr...
NP_967151   155 VLRTDDQFGKAKPLTndvaNLCQKNLSFLREgkKVMCTQGYIGMTEeGITTTLGRGGSDYSAAILAEGVSADvLEIWTDV 234 Bdellovibrio bac...
NP_661001   153 VMITDDRFGFARPLAeicqKNTSEIIKPLLDagTVVVTQGYIGATEsGRTTTLGRGGSDLSAALFGAWLHSEsIEIWTDV 232 Chlorobium tepid...
ZP_00519690 151 VIITDRRHTQAAPNFpetyARLQKTIPPLAAq-SVVVMGGFIGSTEdGVTSTLGRGGSDFTAAIVGAGIQAEeIQIWTDV 229 Solibacter usita...
AAC76994    145 VMRTNDRFGRAEPDIaalaELAALQLLPRLNe-GLVITQGFIGSENkGRTTTLGRGGSDYTAALLAEALHASrVDIWTDV 223 Escherichia coli...
Feature 1                                                                          
2J0W_A      224 PGIYTTDPRVVsaakRIDEIAFAEAAEMATFGAKVLHPATLLPAVRsDIPVFVGSSKDPragGTLVC 290 Escherichia coli
ZP_01042746 235 AGVYSTDPRLCsdafAIAEMSFDEAAEMATFGAKVLHPASLLPAIEyQIPVFVGHAAYPargGTRLV 301 Idiomarina baltica OS145
EAO67827    227 IGVYTTDPRITdaarPLPELSFEEAAEMATFGAKVLHPATMEPALRqNIKVFVGSSKEPekgGTWIV 293 Pseudoalteromonas atlantica T6c
YP_155828   221 AGIYTTDPRICpsarAIAEMSFSEAAELATFGAKILHPSSLAPAIKnDIRVFIGNSQDAlsgGTYIS 287 Idiomarina loihiensis L2TR
YP_268734   233 VGIFTTDPRITdqarAIKEISFGEAAEMATFGAKILHPATLIPAMRrNIPVFVGSSKEPekgGTQIK 299 Colwellia psychrerythraea 34H
NP_967151   235 AGIATTDPRLCpkaqPISEISFKEASELATFGAKVLHPATLLPAIRkNIPVFVGSSFDVearGTWVR 301 Bdellovibrio bacteriovorus HD100
NP_661001   233 DGVMTTDPRIVpeakSIRVMTFSEAAELAYLGAKVLHPDTIAPAVQkNIPVYVLNTWHPdskGTLIT 299 Chlorobium tepidum TLS
ZP_00519690 230 DGMLTADPTILagghRVKTISFAEAAELAYFGAKVLHPATVVPAIEkNIPVMILNSRRPevpGTHIT 296 Solibacter usitatus Ellin6076
AAC76994    224 PGIYTTDPRVVsaakRIDEIAFAEAAEMATFGAKVLHPATLLPAVRsDIPVFVGSSKDPragGTLVC 290 Escherichia coli K12

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