Conserved Protein Domain Family
AAK_NAGK-UC
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cd04251: AAK_NAGK-UC 
AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis. These uncharacterized domain sequences are found in some bacteria (Deinococci and Chloroflexi) and archea and belong to the Amino Acid Kinase Superfamily (AAK).
Links
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Statistics
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PSSM-Id: 239784
Aligned: 8 rows
Threshold Bit Score: 284.646
Created: 15-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putativeputative
Feature 1:putative N-acetyl-L-glutamate binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                          ###                        ##              
AAT44056    2 QVIKIGGSLVs---eILKNNDIINNF---DLNGIIVHGGGNYINEFSKKFGMEQRFVTSPQGIRSRYTDKETLEFFIMVM 75  Picrophilus torrid...
NP_147959  26 AVVKIGGSIAs---rLERVADEIAVLareGLRLVVVHGGGKVVDEYSRRMGVEPRYVLHPSGVRSRYTSWEELEVYVMVM 102 Aeropyrum pernix K1
NP_560327   2 IVVKIGGSVVck--dASKVIQNLPKY---ADRAVVIHGGGCLVNELLKRMGIEPKFLTHPGGLVSRYTDWETLKVFVMAM 76  Pyrobaculum aeroph...
EAM94584    2 KVLKIGGSVLdnfleNDNLYSIIQQF---DCPLAIVHGGGNYLDTHADSFNYTKKFVTSPEGIRSRYTDKNTLEIFTMVM 78  Ferroplasma acidar...
AAK40502    2 IVVKIGGRVVkn--sLDKIILDILNI---NDKVILVHGGGDIVTDYTKRLGIEPVFVTSPEGIRSRYTTKEELEVYIMAM 76  Sulfolobus solfata...
AAF10984   27 IVVKVGGSDGi---dYDAVCADLAERwqaGEKLILVHGGSGETNRVAEALGHPPKFVTSPSGYTSRFTDRQTLEIFEMVY 103 Deinococcus radiod...
EAO59773    2 IVVKIGGSAGn---dYDALCDDIAERwraGERLILVHGGSDQTNRLGEALGHPPRFVTSPSGHTSRYTDRRTLEIFMMAT 78  Chloroflexus auran...
AAV47452    3 VVIKVGGARAv---dPAGALADVASLvadGEQVVVVHGGSTKVDETLERLGVEPEYVETPSGVVGRFTDETTMEVFEMAF 79  Haloarcula marismo...

Feature 1                                                                                     
AAT44056   76 -AYINYKICHILenhGIKTVSISGINNRMAEASrkerlviINERNRKMVIDGGYTGKINKINYDFLKNLVDsGYTPVVSP 154 Picrophilus torrid...
NP_147959 103 aGLLATSISSELasrGLKVLSLTGLDGLSVEARrreriviVNERGRPQAIPGGYTGKIERVDSMFVGSMLQqVDVILYSP 182 Aeropyrum pernix K1
NP_560327  77 -GWINKYIVASLhglGVQALGLTGADLGVVVAKrk---erVLVIDERGRQRVVDGGYVGKIAEIRVDKLTP-PPLKVLAP 151 Pyrobaculum aeroph...
EAM94584   79 -NLINQKLVLNLkehGIKAVTLNGIINARRKEKli----iMNEKNRKMIIDGGYTGRVESADSIPIRAVIDeGYIPVISP 153 Ferroplasma acidar...
AAK40502   77 -SLINKSITSKLcslGKNAIGITGVDGGLLLAErkkrivvIDERGKKRIIEGGYTGKVKEVRSEIINHLVKlFDIIVVSP 155 Sulfolobus solfata...
AAF10984  104 cGKMNKGLVERLqrlGVNAVGLSGLDGRIFEGKhkd-svrSVENGKVKVLRGDHTGTVEKVNTGLIELLLGaGYLPVLTP 182 Deinococcus radiod...
EAO59773   79 aGLINKQLVERLhmrGVMALGLSGLDGRLLSGKrka-tirVIEQGRQMILRDDWTGTIEQVNRDLLHMLLAaGYLPVVAP 157 Chloroflexus auran...
AAV47452   80 -GHLNTQLVAGLqseGVDAVGLTGVDGKLLYGPrks-avrVVEDGKKKIRRGDHSGTIKQVNGDLLETLLGdGYTPVAGP 157 Haloarcula marismo...

Feature 1                  ####                                                               
AAT44056  155 VAf----sVESPLNVDADKMAANIAAALHAeRLLIYTNVDGIYIN----GEKLSKT----DIVSLKs-MKIGNGMIQKVM 221 Picrophilus torrid...
NP_147959 183 VAygregdRVVALNVDGDQMAASLSAALKA-PLALVTDVPGVILD----GRVVDRIrv-sEAREIA--AKAGVGMNRKIL 254 Aeropyrum pernix K1
NP_560327 152 VAvs---eKGELLNIDGDQLAFDVAREAKAeRLILLSDVEGLILG----GKVVPRLtp-eEAEKLVksEEVRGGMKRKLL 223 Pyrobaculum aeroph...
EAM94584  154 VAy----gNGNYLNVDADRAAAYVAGSMGSdSLVFLTNVSGLYYK----DRVIEKAdv-aYIKSIL--NEIGTGMDKKLM 222 Ferroplasma acidar...
AAK40502  156 IAld--veERTPLNIDGDQAAFAISKALRAnVLILLSDVEGVLVE----GKVINRLtp-sEAKELS--KKIGPGMNRKLL 226 Sulfolobus solfata...
AAF10984  183 PAas---yEGVAINVDGDRAAAQLAAALRAeALLLLSNVPGLLRDypdeASLIREIpa-nDVESYL--EFAQDRMKKKVL 256 Deinococcus radiod...
EAO59773  158 LAcs---eAGEAVNVDGDRAAAAIATAIGAqTLILLSNVPGLLRNfpdeSSLITHIpr-nDLESSM--TYAAGRMKKKLL 231 Chloroflexus auran...
AAV47452  158 PMagdddgEVIPVNTDADRSAAAIAGELDA-QLVLLTDVEGVYADpddpSTLIESVetasDWDALE--DAAEGFMGRKIM 234 Haloarcula marismo...

Feature 1                                         
AAT44056  222 AADIAVSsGVREVFIGn------PGNIy---qGTVV 248 Picrophilus torridus DSM 9790
NP_147959 255 MAAKAVSeGSPYAAIGdp----pIQSLingekGTLV 286 Aeropyrum pernix K1
NP_560327 224 MASEAAK-LGIEVVISsglvdspIDAAln-gaGTHI 257 Pyrobaculum aerophilum str. IM2
EAM94584  223 ASIEALEmGVRQVTISn-----pFNGIs---tGTVI 250 Ferroplasma acidarmanus Fer1
AAK40502  227 MAAESVEnGVNKVIIGsgvkdrpIINAle-lnGTVI 261 Sulfolobus solfataricus P2
AAF10984  257 GAAEAVAgGVGRVVFGdaragkpISAAla-geGTVV 291 Deinococcus radiodurans R1
EAO59773  232 GAQEALAgGVQRVILAdaripacVSQAln-ggGTHI 266 Chloroflexus aurantiacus J-10-fl
AAV47452  235 AAEEALDgGASEVVVAdanaespILSAld-ggGTHV 269 Haloarcula marismortui ATCC 43049

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