2CDQ


Conserved Protein Domain Family
AAK_AK-LysC-like

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cd04244: AAK_AK-LysC-like 
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AAK_AK-LysC-like: Amino Acid Kinase Superfamily (AAK), AK-LysC-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive AK isoenzyme found in higher plants. The lysine-sensitive AK isoenzyme is a monofunctional protein. It is involved in the overall regulation of the aspartate pathway and can be synergistically inhibited by S-adenosylmethionine. Also included in this CD is an uncharacterized LysC-like AK found in Euryarchaeota and some bacteria. AK catalyzes the conversion of aspartate and ATP to aspartylphosphate and ADP.
Statistics
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PSSM-Id: 239777
Aligned: 9 rows
Threshold Bit Score: 445.664
Created: 8-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #                                           #                               
2CDQ_A       28 TCVMKFGGSSVASAeRMKEVADLIlt--fpEESPVIVLSAMGk----TTNNLLLAGEKAVS----CGVSNASEIEELSII 97  thale cress
NP_613396     2 RVVMKFGGTSVGTGeSIRKVAKIVtda-aeEHEVIVVVSAMSg----VTDELVRAAESAPDwt-eEDVKNFVGKLRRRHG 75  Methanopyrus kan...
NP_069534     2 RIVMKFGGVSVKDGeNIYHCANLVkkf-seGNEVVVVVSAMQg----VTDALLKAAHRCCSepsaGFIKMFIADMMKRHY 76  Archaeoglobus fu...
NP_247550     2 TTVMKFGGTSVGSGeRIRHVAKIVtkrkkeDDDVVVVVSAMSe----VTNALVEISQQALDvrdiAKVGDFIKFIREKHY 77  Methanocaldococc...
ZP_00767250   2 RLVMKFGGTSVGSAdAIRRVTEIVgty-arDHEVVVVVSAMNapdlrTTDTLIAAAKAAAAgn-gDATAQIAPRLLDLHM 79  Chloroflexus aur...
AAF10936     10 LLVMKFGGTNMQSAhAIRHSASLAgrsvreGVKVVVVVSAMAg----VTNGLLHLADAAQSgd-iARANDEIAALRTRHF 84  Deinococcus radi...
YP_504460     2 KLIMKFGGTSVQNAeSVRRAVDIVydrysrHDRLAIVISARRg----VTDRLITCAEAMVTsrdaAEVTDLVEYLTEGHL 77  Methanospirillum...
XP_470409    81 TVAMKFGGSSVASAeRMREVADLIls--fpEETPVVVLSAMGk----TTNNLLLAGEKAVS----CGAPKASEIPELAVI 150 Oryza sativa (ja...
AAM03585      2 KIVMKFGGTSVGDGkKIRHVAQLLkryheeGNQIVVVTSALGg----VTDRLLENARLASTkgkvSLVKEFKTELTNKHH 77  Methanosarcina a...
Feature 1                                                           #                           
2CDQ_A       98 KELHIRTVKELNi--DPSVILTYLEELEQLLKGIAMMKELTLRTrdYLVSFGECLSTRIFAAYLnTIGVKARQYDAFEIG 175 thale cress
NP_613396    76 KAASEAISSDLIrreVMGYVDSLLEELEKVLLGLSYVGEVTPRSmdLILSFGERMSAPIVAGALrDRGLEAEHLEGGEAG 155 Methanopyrus kan...
NP_069534    77 EAIEYAVRNDEIkakVIAAVERLLDELEKVLLGISYLGELTRRSedYIVSFGERLSAPIFSAALlSLGVDSVALTGGDAG 156 Archaeoglobus fu...
NP_247550    78 KAIEEAIKSEEIkeeVKKIIDSRIEELEKVLIGVAYLGELTPKSrdYILSFGERLSSPILSGAIrDLGEKSIALEGGEAG 157 Methanocaldococc...
ZP_00767250  80 RTAAEVASPAECa-aLEPQIRSMLDYMSNLSRSIAVLGELTPRAldLFSGLGERLNARLIAAALrSAGIDAEAIDATELI 158 Chloroflexus aur...
AAF10936     85 TAAQELGAAPDSe--TVRELRELHETLRQAVYGVYLLRELTPRSrdLIVAFGERLSAPLMSLALeQSGLRARHLTGGEAG 162 Deinococcus radi...
YP_504460    78 STLKEVAPDFSPe--VSGIITRRIENLRDFLYAVYHLRELTVRSrdYIISFGERLNAPIISAALrQRGIPSMVLDGCEAG 155 Methanospirillum...
XP_470409   151 KELHVRTIDELGl--DRSIVSGLLEELEQLLKGVAMMKELTPRTrdYLVSFGECMSTRIFAAYLnKLGKKARQYDAFDIG 228 Oryza sativa (ja...
AAM03585     78 EAVKDAIEDPRVakeVLQVLDLRIEELEKALIGICYLGELTSRSidYISSYGERLAAPIVSGAVrSLGAASIEYTGGEAG 157 Methanosarcina a...
Feature 1                                                                  #                    
2CDQ_A      176 FITTDDFTNGdil-eaTYPAVAKRLYDDWMhdpAVPIVTGFLGKGwKTGAVTTLGRGGSDLTATTIGKALGLKEIQVWKD 254 thale cress
NP_613396   156 VITDDGFGEAepilpaCRRKAQKTLIPMIEs-gKIPVITGFIGRT-IDGEVTTLGRGGSDYSAAIIGCISEADEVQIWTD 233 Methanopyrus kan...
NP_069534   157 IITDRNFGRAkpl-pgVYTTIRNRLEPLLTikkTIPVVTGFIGAT-DDGSITTLGRGGSDYTATILAAALDADEVWLWKE 234 Archaeoglobus fu...
NP_247550   158 IITDNNFGSAr----vKRLEVKERLLPLLKe-gIIPVVTGFIGTT-EEGYITTLGRGGSDYSAALIGYGLDADIIEIWTD 231 Methanocaldococc...
ZP_00767250 159 VTDDRYGNASpie-pdTRERSRARLLPMLAd-rKVPVVTGFIGAT-RAGVPTTLGRGGSDYTCAILGADLDADEVWFWKE 235 Chloroflexus aur...
AAF10936    163 ILTDTNFGNArpl-pgTYERVGDRLSGFLSa-gVTPVIAGFMGET-EQGAITTLGRGGTDFSATIVGKALGADEVWAWKD 239 Deinococcus radi...
YP_504460   156 ILTTENHGDAial-paGEARIKSRLEPVIDh--SVPVITGFMGCT-EKGVVTTLGRSGSDYSATIIGAALDADEIWIWTD 231 Methanospirillum...
XP_470409   229 FITTDDFTNAdil-eaTYPAVAKRLQGDWIddpAIPIVTGFLGKGwKSCAVTTLGRGGSDLTATTIGKALGLREIQVWKD 307 Oryza sativa (ja...
AAM03585    158 IVTTSDYGNArpl-ekTYELVLKRLGCRLEs--HILVVTGFIGEN-EDGIITTLGRSGSDFSASILGAALKADEIWLWKE 233 Methanosarcina a...
Feature 1                               #            #                              
2CDQ_A      255 VDGVLTCDPTIYKRATPVPYLTFDEAAELAYFGAQVLHPQSMRPAREGeIPVRVKNSYNPKaPGTIIT 322 thale cress
NP_613396   234 VDGVMTANPNLVPDARTVPRLSYEEAMELASFGAEVLHPKTVIPARSEnIPIRVKNTFNPEsEGTLIT 301 Methanopyrus kandleri AV19
NP_069534   235 VDGIMTCDPKYVPNARVIPEISYQEAMELSHFGAKILHPRALEPVMRKnIPVRIKNTFNPDaPGTVIG 302 Archaeoglobus fulgidus DSM 4304
NP_247550   232 VSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKgIPILVKNTFEPEsEGTLIT 299 Methanocaldococcus jannaschi...
ZP_00767250 236 VDGVLSANPKVVPEARTLPRLSYAEMGEMAYYGANVLHPKTVQPLVHRrIPIRIRNTFNPShPGTLID 303 Chloroflexus aurantiacus J-1...
AAF10936    240 VDGVMSADPRVVGDASNIGVLSYGEVMELAYFGAKVLHPLAVTPLQDSgIPLRVKSAADPDfAGTLVR 307 Deinococcus radiodurans R1
YP_504460   232 VDGIMTTDPRLVPEARVIPRISYIEVMELSYFGAKVMHSRSIEPAMQKgIPVWVKNTFNPSyPGTVIE 299 Methanospirillum hungatei JF-1
XP_470409   308 VDGVLTCDPNICANAIPVPYLTFEEAAELAYFGAQVLHPQSMRPAKEGdIPVRVKNSYNRRaPGTVIT 375 Oryza sativa (japonica culti...
AAM03585    234 VNGIMTTDPRIVPEAKTIPQISYAEAMELSYFGANVLHPRTIEPAMREhIPVRVKNTFNPEfPGTLVV 301 Methanosarcina acetivorans C2A

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