1E19,1B7B


Conserved Protein Domain Family
AAK_CK

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cd04235: AAK_CK 
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AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an essential precursor of arginine and pyrimidine bases, in the presence of ATP, bicarbonate, and ammonia. CK is a homodimer of 33 kDa subunits and is a member of the Amino Acid Kinase Superfamily (AAK).
Statistics
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PSSM-Id: 239768
Aligned: 68 rows
Threshold Bit Score: 322.152
Created: 26-Sep-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:putative substrate binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to Arabidopsis thaliana Lys/SAM-sensitive aspartokinase, Escherichia coli NAG kinase, and Pyrococcus furiosus UMP kinase
  • Structure:1B7B; Carbamate kinase from Enterococcus faecium bound with sulfate.
  • Comment:bound sulfate proposed to occupy the site of the phosphoryl group of the substrate carbamoyl phosphate
  • Comment:defined by 3.5 Angstrom contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           # ##                                        ###                             
1E19_A        4 RVVIALGGNALQqrgqkgsyeeMMDNVRKTARQIAEIIargyEVVITHGNGPQVGSLLLhmdagqatygipaQPMDVAGA 83  Pyrococcus furiosus
AAT43175      3 RIVIALGGNAIDsgns--gineQIEKAVKAFSELADIIsn-nEVAITYGNGPQVGNIYEk-----------gYDLDLSVA 68  Picrophilus torr...
EAM93706      3 RIVIALGGNALDngks--sideQIEKASETFLRLSEIInn-nEVVITYGNGPQVGEIYDkt----------gYPLDISGS 69  Ferroplasma acid...
1B7B_A        4 KMVVALGGNAILsnda--sahaQQQALVQTSAYLVHLIkqghRLIVSHGNGPQVGNLLLqqqaad-seknpaMPLDTCVA 80  Enterococcus fae...
CAC12471     37 RIVIALGGNALLqngekrdyetQYEHAYKTFESLRFVTed-nEVVITHGNGPQVGDIQQshdi-----sgigAYLHQSVA 110 Thermoplasma aci...
ZP_00660141  14 RVLLALGGNAMTnadgrarpedQIAAARVAMDAVADLLgadvEVVITHGNGPQVGNLLVknelaa--gvvppVPLDWCGA 91  Nocardioides sp....
YP_133566     7 IIVVAVGGNALLqrgelmsydnQFNNIAVATQALAKLSee-yQVVIVHGNGPQVGLLALqnlay---sdappYPLDVLGA 82  Photobacterium p...
ZP_00989526   5 IIVVAVGGNALLqrgevmscenQKKSIAQTASSLAELSkd-yRLVVVHGNGPQVGLLSLqnnay---kdcppYPFDVLGA 80  Vibrio splendidu...
YP_207104     9 TIVIALGGNALLrrgqvlsyenQLENVKVAAESIAKLSke-yRIAIVHGNGPQVGLLSQqndaf---davpsYPLSCLVA 84  Vibrio fischeri ...
NP_559375     2 KVVIALGGNAFNkpgepinqdaHLKNIEAAAKIIQRIVqeghQVVVTHGNGPQVGYFAElqrd------sqaFKLDAINA 75  Pyrobaculum aero...
Feature 1                                                      #                                
1E19_A       84 MSQGWIGYMIQQALKNELrkrgmeKKVVTIITQTIVDknDPAFqnptKPVGPFYdeETAKRLarekgwiVKEDs-gRGWR 162 Pyrococcus furiosus
AAT43175     69 MSNGMLSYIISMAYDRAKyisgisKDIITMVTRTVVN--PDIYt--mKPVGRFYd-KKIDDSy------YYEIn--RGYR 135 Picrophilus torr...
EAM93706     70 MSQGLLLHILAMAYGSLKisgklkKNIVPILTNTVID--ENKYt--lKPIGPFFd-HKIDDTy------AMEMn--KGYR 136 Ferroplasma acid...
1B7B_A       81 MTQGSIGYWLSNALNQELnkagikKQVATVLTQVVVDpaDEAFknptKPIGPFLteAEAKEAmqa-gaiFKEDa-gRGWR 158 Enterococcus fae...
CAC12471    111 MSQGYIGEILANAYTNIKtkynlrKNIFTIITRVLVDenDPAFsnpeKPIGRYYsdAEVEEArkn-gwiMKKFr--DGWR 187 Thermoplasma aci...
ZP_00660141  92 QTQATLGFVLMNALEAALaergveRRTATLVTRALVDadDAGFtnptKPIGRFLpaDEAAVLieh--geTWEDrgaKGWR 169 Nocardioides sp....
YP_133566    83 ETQGMIGYMMAQGLKRSAp----nGNFSTLLTQVIVDenDPAFtdpnKFIGPVYdqQTAEDKaqqfgwtIKPDg--QYWR 156 Photobacterium p...
ZP_00989526  81 ETQGMIGYLIQQGLNAAIk----dRFTTTILTRIVIDenDPAIadpaKFIGPIYteEQAKQLaeanqwvVKPDg--AHWR 154 Vibrio splendidu...
YP_207104    85 ESQGMIATMLAQELRNRVd-----CNVTTILTHVDVDkaDPAFndptKFIGQVYseKEAYDLteefgwsIRQDg--DYFR 157 Vibrio fischeri ...
NP_559375    76 LTQGLLGYLIVSALDKALg----rGRSAALVTRVEVDcsDPAFktptKYIGPIYseEEAKKLgvmygwqFKQDp-rGGWR 150 Pyrobaculum aero...
Feature 1                                                           ###                         
1E19_A      163 RVVPSPDPKGHVEAETIKKLVERgVIVIASGGGGVPVIled-geIKGVEAVIDKDLAGEKLAEEVNADiFMILTDVNGAA 241 Pyrococcus furiosus
AAT43175    136 KRVKSPEPVDILEKSAISNLMANgFLPVAVGGGGIPVVqtl-qyYSGFPGVIDKDLASALLGNLIDADtLMIITGVKNIY 214 Picrophilus torr...
EAM93706    137 KMVKSPEPASILEIDSIINLVSNgYLPLAVGGGGVPVEiln-kkYMGFQGVIDKDLSSSLLATLLNAKkFIIITDVNNVY 215 Ferroplasma acid...
1B7B_A      159 KVVPSPKPIDIHEAETINTLIKNdIITISCGGGGIPVVgq---eLKGVEAVIDKDFASEKLAELVDADaLVILTGVDYVC 235 Enterococcus fae...
CAC12471    188 RVVPSPDPRQILEEPVIEYLLHNgNLPIAVGGGGVPVVrkg-eqIHGIDAVIDKDLASSVLATAIRADfLMILTDVDNVY 266 Thermoplasma aci...
ZP_00660141 170 RVVASPEPIEILDAPAVAALVAAgFVVVANGGGGIPTVrepdgtLRGVEAVIDKDLGAALLAGTVAADvLVIGTDVPNAV 249 Nocardioides sp....
YP_133566   157 RVVPSPKPQHILELDSIRTLLAAdHTVICCGGGGCPVIktp-ngYDGIEAVIDKDLSAAMLAKELGAQhFLILTDGDNVC 235 Photobacterium p...
ZP_00989526 155 RVVPSPSPKEVLEIKAIKDLLEKeHLIICGGGGGAPVVekd-gaYVGFEAVIDKDMTAALIAEEIGAEhLLILTDGSHVC 233 Vibrio splendidu...
YP_207104   158 RVVASPAPKNIRESELISLALQHdNIVICCGGGGIPVCtdnhgiTTNIDCVIDKDSTASLLSQQISADyFLILTDGDGVF 237 Vibrio fischeri ...
NP_559375   151 RVVPSPTPLRIVEIDIIKRLADAgYVVVAAGGGGIPVCe-----NTGVEGVVDKDLASSLLAIEWKADlLIILTDVDGVY 225 Pyrobaculum aero...
Feature 1                                                                                
1E19_A      242 LYYGTekEQWLREVKvEELRKYyeeghFKAGSMGPKVLAAIRFIEWgg-eRAIIAHLEKAVEAlegktGTQVL 313 Pyrococcus furiosus
AAT43175    215 LDYSKk-DGIIKSIDyDKMLDYyntinFEEGTIKPKILAALKFLERgg-rKVYITSIENIKNLn---dGTVIY 282 Picrophilus torridus DS...
EAM93706    216 LDFKNk-SDPINKISyKQMLEYynkikFEEGTIKPKILAALRFIEHgg-eKVYITSISNIENMe---sGTVID 283 Ferroplasma acidarmanus...
1B7B_A      236 INYGKpdEKQLTNVTvAELEEYkqaghFAPGSMLPKIEAAIQFVESqpnkQAIITSLENLGSMsg--dEIVGT 306 Enterococcus faecalis
CAC12471    267 VNYGKpdQKGLHEVHvEEIEKYlkegqFGEGSMKPKVMAAIRFIKNgg-kKAFITSIENSMNAlsgrsGTIIV 338 Thermoplasma acidophilum
ZP_00660141 250 LRYGApdAEPLGRVTvSELRAHaaaghFASGSMGPKVDAACRFVEAgg-sRAVITDLTHITQAitgdaGTVVV 321 Nocardioides sp. JS614
YP_133566   236 VDWGTptEKPLHHVTvKELNQYt----FAAGSMAPKVDACCEFALEtl-gTGHIGSLHKAYEImmdqsGTHIR 303 Photobacterium profundu...
ZP_00989526 234 LDWGTpkEEKLENVSvEQMKKYt----FPAGSMGPKVDACCQFVEKtk-qHGYIGDLSSALEIiegktGTHIN 301 Vibrio splendidus 12B01
YP_207104   238 FHYGKpnQIKLDIATtEELKGYs----FDKGSMQPKIDSMINYVENvdisIGIIADLHLALDAlngtaGTKIV 306 Vibrio fischeri ES114
NP_559375   226 LNFKKpgQRKLDAVRvDELEKYyaeghFPPGSMGPKVLAAINFIRNgg-kRAAIGALEEGYEVfkgvrGTQII 297 Pyrobaculum aerophilum ...

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