1KCW


Conserved Protein Domain Family
CuRO_5_ceruloplasmin
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cd04225: CuRO_5_ceruloplasmin 
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The fifth cupredoxin domain of Ceruloplasmin
Ceruloplasmin is a multicopper oxidase essential for normal iron homeostasis and copper transport in blood. It also functions in amine oxidation and as an antioxidant preventing free radicals in serum. The protein has 6 cupredoxin domains with six copper centers; three mononuclear sites in domain 2, 4 and 6 and three in the form of trinuclear clusters at the interface of domains 1 and 6. Ceruloplasmin exhibits internal sequence homology that appears to have evolved from the triplication of a sequence unit composed of two tandem cupredoxin domains. This model represents the fifth cupredoxin domain of ceruloplasmin.
Links
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Statistics
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PSSM-Id: 259887
Aligned: 6 rows
Threshold Bit Score: 307.472
Created: 4-Jun-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Domain 4Domain 6
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:Domain 4 interface [polypeptide binding site]
Evidence:
  • Structure:1KCW: Human Ceruloplasmin domains 4 and 5 interface; contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
1KCW_A        713 RTYYIAAVEVEWDYSPQREWEKELHHlqeq-nvsNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERka---------- 781  human
CAG00485      653 VQYFISAEEIEWDYSPQRHWEQELHNtkn--spgDKYLEKGKYRIGSRYKKVVYREYTDDTFSVQKKRqasqkhlgilgt 730  Tetraodon nig...
AAK55535      284 KKYYIAAVEMDWDYSPTRTWEDKMHNglke-spgNEFLKKEGKFIGSKYKKVLYKEYTDETFTKLKERta---------- 352  zebrafish
Q9BQS7        733 RIYYIMAEEVEWDYCPDRSWEREWHNqsekdsygYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRtg---------- 802  human
XP_001235149  728 KTHYIAAVEVEWDYSPNRTWEFERHQyhke-spgNPFLNKDDKFIGSKYKKVVYREYTDQTFSIPKSRae---------- 796  chicken
XP_002937375  727 NTYYIAAEEIEWDYSPNRTWEHERHIhhge-spgDAFLNKGEKFIGSTYKKAVYRQYTDRTFTKRKERne---------- 795  western clawe...

Feature 1                                                             ## ##                      #
1KCW_A        782 ----------------eeEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTess-tvtPTLPGETLTYVWKIPE 844  human
CAG00485      731 vrfyfllfvfvetrndnfFVFTCIGPIIRAEVGEQIVITLKNKASRPYSITAHGVKAsgv--rsPVKPGHIIELTWDVLE 808  Tetraodon nig...
AAK55535      353 ----------------dmEHLGIMGPMIHGKVGEKVKIVFKNMARRPYSIHAHGVKTdsp-qvaLTRPGETQTYTWYLPK 415  zebrafish
Q9BQS7        803 ----------------peEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLEsttvwplAAEPGEVVTYQWNIPE 866  human
XP_001235149  797 ----------------eeQHLQIQGPLIMSSIGDKINIVFKNLASRPYSIHAHGVKTdss-avaITNPGETKMYVWKISA 859  chicken
XP_002937375  796 ----------------eeKHLGILGPLLIARTHEKVKIVFKNMASRPYSIYAHGVKTdgp--vvQTEPGQTQTYIWKIPE 857  western clawe...

Feature 1         ###### ##     #  #    ##   #            
1KCW_A        845 RSGAGT-EDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRR 883  human
CAG00485      809 SSGPGV-SDPNCISYPYYSNVNFIKDLYSGLLGPLVICRP 847  Tetraodon nigroviridis
AAK55535      416 NSGPTE-EQEECSVGAYYSTVDVIKDMYSGLVGPLVICKK 454  zebrafish
Q9BQS7        867 RSGPGP-NDSACVSWIYYSAVDPIKDMYSGLVGPLAICQK 905  human
XP_001235149  860 RSGSER-GDLHCTAWAYHSMVDIIKDTYSGLIGTLVVCPR 898  chicken
XP_002937375  858 RSGPGYhEDVNCVTWAYYSTVDQVKDTYSGLIGPLVICKR 897  western clawed frog

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