Conserved Protein Domain Family
MauL
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cd04221: MauL 
Methylamine utilization protein MauL
MauL is one of the products from the methylamine utilization gene cluster in Methylobacterium extorquens AM1. Mutants generated by insertions in mauL were not able to grow on methylamine or any other primary amine as carbon sources. MauL belongs to the blue or type I copper protein family. They are involved in electron transfer reactions with the Cu center transitioning between the oxidized Cu(II) form and the reduced Cu(I) form.
Links
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Statistics
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PSSM-Id: 259883
Aligned: 11 rows
Threshold Bit Score: 92.4341
Created: 30-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Type 1
Feature 1: putative Type 1 (T1) Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H C H XClick to see conserved feature residue pattern help
Evidence:
  • Comment:predicted based on homologous protein.
  • Comment:Type 1 (T1) copper sites are characterized by their conserved H...C...H...M copper ligands.
  • Comment:Some members bind copper at the T1 site with three amino acid residues (HCH), instead of four (HCHM).
  • Citation:PMID 2716059
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                    #                                
YP_972607  63 SAEVAQekr-------------tfvPEVLVVTaGTQVQFPNHD-TVRHHVYSFSPAKKFEik-----lySGTPANPVLf- 122 Acidovorax avenae ...
AAO57665   56 TASMDQreq-------------efaPHVLAVHvGTEVKFPNSD-NIRHQVYSFSQAKRFElr-----lyEGTPSDPLLf- 115 Pseudomonas syring...
NP_762512  41 VAELSQnhr-------------tftPNVLVITkGSAVEFPNRD-RVRHHVYSFSNAKTFElk-----lySGRPEKPVVf- 100 Vibrio vulnificus ...
BAC46820   35 PYVISQkdr-------------efrPQEIVIKrGETLRFINDDgELMHHTYLSSDTFEFDsgd----qqPGSQFDVVF-- 95  Bradyrhizobium jap...
YP_155325  45 SAVVDQvdk-------------qftPTVSAVEpGTDVVFPNSD-NIRHHVYSFSEAKNFElk------lYSDKEKPSVn- 103 Idiomarina loihien...
YP_000667  23 EHEVGQknk-------------gftVESLKIKvGDVVSFPNYD-TFYHNVYSLSPAKIFDlgs----ysQGKTQKVKF-- 82  Leptospira interro...
Q50234     40 HAPLKQsasdpahshrmtlsdhefaPVDFEPQpGDTITIRNRS-DISHSIYVTYPDGTMVnlg---vqtPGTTVHWQVp- 114 Methylophilus meth...
NP_865073  98 THELANdkc-------------rfePHYVIAQtGDTLKITNPD-TVGHNANLNFFANKAEnlm----ipAGANKEVALe- 158 Rhodopirellula bal...
Q50422     55 SAEVHQmelth----------hefePWSFVPKpGDRIDIHNHS-DIVHAIYVTYPNGIVVnlsetaaqlPGMTVSWTVpe 123 Methylobacillus fl...
NP_868882  92 SKPSKQtrklla-------kecrfePHVVLAQsGDTLIFDVSEaKVGHNININFFRNNHSgil----ipAGNNRDFSLq- 159 Rhodopirellula bal...
Q49129     35 HHVELQd------------------PGLKAKV-GDAISFVNHA-DISHNLYLTYEDGQVEtld---tqpPRTTKRTVL-- 89  Methylobacterium e...

Feature 1                #  #  #      
YP_972607 123 --DQPGVVVLGCNIHDQMVGWILV 144 Acidovorax avenae subsp. citrulli AAC00-1
AAO57665  116 --DKPGVVVLGCNIHDWMVGYIYV 137 Pseudomonas syringae pv. tomato str. DC3000
NP_762512 101 --DKAGVVEIGCNIHDSMLAWILV 122 Vibrio vulnificus CMCP6
BAC46820   96 --SVAGDYTVLCGIHPKMKLGVHV 117 Bradyrhizobium japonicum USDA 110
YP_155325 104 -fDKAGIVTLGCNIHDQMVAYVLV 126 Idiomarina loihiensis L2TR
YP_000667  83 --EKSGKITVQCAIHPEMKMTIEV 104 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
Q50234    115 -aDAKGEFVLQCWIHPIIRANLLV 137 Methylophilus methylotrophus
NP_865073 159 -kPEPAAIPVECNIHPWMRAYVVV 181 Rhodopirellula baltica SH 1
Q50422    124 daEDGDEYVLQCWIHTIIRAALKV 147 Methylobacillus flagellatus KT
NP_868882 160 -kAEPAPLPIDCNIHPWMRAWLVV 182 Rhodopirellula baltica SH 1
Q49129     90 --KRAGHVVVRCWIHPIIRMEFDV 111 Methylobacterium extorquens

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