1ADW,1BQK,1PMY,3EF4


Conserved Protein Domain Family
Pseudoazurin
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cd04218: Pseudoazurin 
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Pseudoazurin (Paz) is a type I blue copper electron-transfer protein
Pseudoazurin (PAz) has been identified as an electron donor to the denitrification pathway. For example, PAz acts as an electron donor to cytochrome c peroxidase and N2OR from Paracoccus pantotrophus (Pp), and to the copper containing nitrite reductase (NiR) that catalyzes the second step of denitrification. It has been shown that pseudoazurin dramatically enhances the reaction profile of nitrite reduction by Paracoccus pantotrophus cytochrome cd1 and facilitates release of the product nitric oxide. The ability of this small redox protein to interact with a multitude of structurally different partners has been attributed to the hydrophobic character of the binding surface.
Links
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Statistics
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PSSM-Id: 259880
Aligned: 24 rows
Threshold Bit Score: 149.372
Created: 1-Feb-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Type 1 (T1) Cu
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Type 1 (T1) Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H C H MClick to see conserved feature residue pattern help
Evidence:
  • Comment:Blue copper proteins are characterized by their conserved H...C...H...M copper ligands
  • Structure:1ADW: Paracoccus pantotrophus Pseudoazurin binds copper through a Type 1 (T1) copper site.
  • Citation:PMID 7583671
  • Structure:1BQK: Achromobacter cycloclastes Pseudoazurin binds copper through a Type 1 (T1) copper site.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 #                                     #
1ADW_B         2 THEVHMLNkge---sgaMVFEPAFVRAEPGDVINFVPTDkSHNVEAIKEilPEGVESFKSKINESYTLTVTePGLYGVKC 78  Paracoccus deni...
NP_357212     26 VVAGFPLHasa----etMVFEPDFLEIGPGDRVRFVPTHkSHNAATIDGmvPEGVEGFKSRINDEFETGFEkPGFYGIKC 101 Agrobacterium t...
NP_386936     23 EYRVEMLNkaad--grvMAFEPAVIRAQPGDTVTFVAKDkGHNSALMKGgaPEGAETWKGKINEEITVTLSkPGVYMYQC 100 Sinorhizobium m...
EAL52881      21 NYEVKMLDldsk--nqtMIFEPAVLHIEVGDSVTFVPTHkSHWAKSVIV--PKGASKFESKLDEKATFTFEkEGVYLYEC 96  Campylobacter u...
YP_342323     27 THIIKSIG---------TAFNPIIVFAEPGDTITWINMP-AHNTKSINGliPQAAKPWQSQMGQDFSVTLEeEGIYLYEC 96  Nitrosococcus o...
YP_426227     24 TFDVKMLTrgv---hgsMVFEPEDITLAPGDTLRFLPSDrSHNAASIPSmlPAGAVAFKGKIDQETSVTFDvPGVYGIKC 100 Rhodospirillum ...
YP_682906     32 RHSVLMLNaacgdaqrlNLFEPAILRVNAGDTVTFLATDsGHNTASKRGmiPQGATPWNGGIDEEISVTLSiPGIYGYIC 111 Roseobacter den...
YP_001352138  21 EHQVKMVNngk---dgmMSFEPTFLKAEKGDTVKFIKTDaAHNSASVLV--PAGAKEWKGKMDEEIVVSLTqDGVYVYVC 95  Janthinobacteri...
YP_001452840  24 THEVLMKNrga---ggpMVYEPDYLAIQPGDTVKFIRKHkSHNAASIAElsPAGYPGFVGKIDEEIEVKYDkPGFYGIKC 100 Citrobacter kos...
YP_001534021  28 QTVVEMLNkdpdnprlrMVFSPRIVVVQPGDTVKFAATDpSHNSASIDGmlPEGAEAWNGKINEEIVVPFPtPGFYGYKC 107 Dinoroseobacter...

Feature 1          #    #                                        
1ADW_B        79 TPHFGMGMVGLVQVGDa--pENLDAAKTak-----mPKKARERMDAEL 119 Paracoccus denitrificans
NP_357212    102 SPHYGMGMVMLIKVGE----AALPQSYRev----evPGRAKTRLDDLF 141 Agrobacterium tumefaciens str. C58
NP_386936    101 APHVGMGMIGAIVVGEp---ANLEAVKGik-----yPGKSKAAAEKIF 140 Sinorhizobium meliloti 1021
EAL52881      97 PPHRIMNMLGFIQVGKa---ENLEQIKNavpklekrAMMNQGRLEAYV 141 Campylobacter upsaliensis RM3195
YP_342323     97 NPHLSFGMAGAIVVGEp---KNLAELEKkvn---ytHGAIQRVFRKTK 138 Nitrosococcus oceani ATCC 19707
YP_426227    101 SPHFAMGMVMLVRVGA----GSPAEITLpa----dlPERARTRFEEII 140 Rhodospirillum rubrum ATCC 11170
YP_682906    112 LPHYEMGMVGLIIAGDn--lTNLAAASKlr-----hPGQAHAAFRALL 152 Roseobacter denitrificans OCh 114
YP_001352138  96 DPHKTMGMAGVIQVGKp---TNLDAAKAeadklsksFVMNKDRLTKAL 140 Janthinobacterium sp. Marseille
YP_001452840 101 TPHYAQGMVMLIKVGD----ATLPDSYRtf----kaPGIADKRFQDIY 140 Citrobacter koseri ATCC BAA-895
YP_001534021 108 TPHAATGMVGLVIVEGagmmANLEAAQGvk-----qRGRAAKVWEEIW 150 Dinoroseobacter shibae DFL 12

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