3G5W,3GDC,4E9V


Conserved Protein Domain Family
CuRO_D2_2dMcoN_like
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cd04202: CuRO_D2_2dMcoN_like 
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The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins.
This family includes bacterial two domain multicopper oxidases (2dMCOs) represented by the McoN from Nitrosomonas europaea. McoN is a trimeric type C blue copper oxidase. Each subunit houses a type 1 copper site in domain 1 and a type 2/type 3 trinuclear copper cluster at the subunit-subunit interface. The 2dMCO is proposed to be a key intermediate in the evolution of three domain MCOs. The biological function of McoN has not been characterized. Multicopper oxidases couple oxidation of substrates with reduction of dioxygen to water. These MCOs are capable of oxidizing a vast range of substrates, varying from aromatic to inorganic compounds such as metals.
Links
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Statistics
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PSSM-Id: 259865
Aligned: 55 rows
Threshold Bit Score: 103.102
Created: 31-Jan-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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trinuclear Cutrimer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: trinuclear Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:3GSW; Trinuclear binding site of two-domain multicopper oxidase from Nitrosomonas europaea.
  • Comment:Trinuclear copper site ligands are typically one or two HxH motifs that can be in the same domain/subunit or in different domains/subunits.
  • Comment:There are three trinuclear copper binding sites in between subunits in the functional trimer.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                            # #         
3G5W_A       136 TKDYILMLSDwvsswankpgeggipgdvFDYYTINAKSFPeTQPIRVKKGDVIRLRLIGAGd-hVHAIHTHGHISQIAfK 214 Nitrosomonas eu...
NP_982219    415 TATYTMDLNTqmn-------------gnEMVYTINGKTFPdIDPIQVKKGDLVKVKLVNKSktdDHPMHLHGHFFQVLsK 481 Bacillus cereus...
ACV83921     364 TDEYEMTLSPee---------------dNGVETINGKLFPnDELNEVDDRDKLKANFINHGd-fDHPMHLHGPFFRVPsD 427 uncultured bact...
YP_004640838 357 DHSHTLTLDQn-----------------LFINSINGKSFHeIPPIIVNEGDRVKLTITNIGg-gDHPFHLHGHRFQVLsR 418 Paenibacillus m...
YP_003340430 450 DRKFTIVASDgvgfv---------dgslDLIQAFNGRVYPnVPTQMVREGDLVKMTLVNRSr-dNHPMHLHGHHAMVLsA 519 Streptosporangi...
YP_004542382 375 DRHFTYTIGRrpgfv---------dgrpGMQWTVNGRTFPdVPMFTVREGDVVRMTLSNASg-eAHPMHLHGHHVVVLeR 444 Isoptericola va...
YP_003588206 400 DASYTWHLNSaiv-------------ngQLAYTINGKVWPyTDPIAVKTGDRVKVTLINDGq-sDHPMHLHGHVFRVLtR 465 Bacillus tuscia...
EJS65354     400 TKVYDMDLAEgvkdv---------ngqeKWVYTINGKTSPnIPPIKVEKGDKVKIRFKNKGe-eIHPMHLHGHTFQVIsK 469 Bacillus cereus
EKP95509     427 DVQYTMELGTgmg-------------enGVIYTINGKTFPdTPPIRVKEGDLVQVRIVNRSptdEHPMHLHGHFFQVLsR 493 Thermaerobacter...
EGK10284     364 DEEIKADLGEgmdh-----------pnmKMVYTINGKTFDeSEPFQVKKGDKVKLRMENTGr-qNHPMHLHGHFFQVIrK 431 Desmospora sp. ...

Feature 1                                             # #                      
3G5W_A       215 DGFPLdk-piKGDTVLIGPGERYDVILNMDNPGLWMIHDHVDTHTtngdkpdGGIMTTIEYE 275 Nitrosomonas europaea
NP_982219    482 DGKPIegspiIKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHAs------AGMVTEVKYK 537 Bacillus cereus ATCC 10987
ACV83921     428 DGKNIpgspwKKDTLNIDPGESYEWLFDRTNPGIWMFHCHDIHHAs------NTMVDETDYD 483 uncultured bacterium
YP_004640838 419 NGVPLsgspvYLDTLLTQQDETFEIYVKADNPGLWMMHCHNLMHAs------MGMSMMLNYE 474 Paenibacillus mucilaginosus KNP414
YP_003340430 520 NGRPVsgspwWIDTLDLPPGTWFEIGFRADNPGLWMDHCHNLEHAa------AGMMMHLGYE 575 Streptosporangium roseum DSM 43021
YP_004542382 445 DGVPAsgspwWVDSLDVRQGETYEVAFVADNPGVWMDHCHNLPHAa------EGLVAHLMYE 500 Isoptericola variabilis 225
YP_003588206 466 NGVPVqg-dvEKDTLLVRPGETYEIGFVADNPGVWVFHCHDLHHAa------AGMMSDVEYQ 520 Bacillus tusciae DSM 2912
EJS65354     470 NGKPMegspiYLDTVNVFPGEEYEIALEANNSGLWMVHCHHLVHAek---gmHTMMNYEGVT 528 Bacillus cereus
EKP95509     494 NGKPLtgapvIKDTLNVKPGEEYVIAFRADNPGNWVFHCHELHHAa------GGMVTQVLYD 549 Thermaerobacter subterraneus
EGK10284     432 NGKPVns-mpMKDTLNVRPGESYEIAFEADNPGDWMFHCHDLHHAa------DGMATLLKYK 486 Desmospora sp. 8437

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