2J5W,2J5W,2R7E,1KCW,1KCW,2R7E,2R7E,2J5W,1SDD,1SDD


Conserved Protein Domain Family
CuRO_2_ceruloplasmin_like
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cd04200: CuRO_2_ceruloplasmin_like 
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Cupredoxin domains 2, 4, and 6 of ceruloplasmin and similar proteins
This family includes the second, fourth and sixth cupredoxin domains of ceruloplasmin and similar proteins, including the second, fourth, and sixth cupredoxin domains of unprocessed coagulation factors V and VIII. Ceruloplasmin (ferroxidase) is a multicopper oxidase essential for normal iron homeostasis. Ceruloplasmin also functions in copper transport, amine oxidase and as an antioxidant preventing free radicals in serum. The protein has 6 cupredoxin domains and exhibits internal sequence homology that appears to have evolved from the triplication of a sequence unit composed of two tandem cupredoxin domains. Human Factor VIII facilitates blood clotting by acting as a cofactor for factor IXa Factor VIII and IXa forms a complex in the presence of Ca+2 and phospholipids that converts factor X to the activated form Xa.
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Statistics
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PSSM-Id: 259863
Aligned: 12 rows
Threshold Bit Score: 171.054
Created: 15-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Type 1 (T1) Cu
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Type 1 (T1) Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H C H XClick to see conserved feature residue pattern help
Evidence:
  • Structure:2J5W; Human ceruloplasmin cupredoxin domain 4 binds copper at the T1 site.
  • Comment:Type 1 (T1) copper sites are characterized by their conserved H...C...H...M copper ligands.
  • Structure:2J5W: Human Ceruloplasmin cupredoxin domain 2 binds copper at T1 site.
  • Comment:Some members bind copper at the T1 site with three amino acid residues (HCH), instead of four (HCHM).
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
2J5W_A     214 DREFVVMFSVVDENFSWyledniktycsepekvdkdnedfqqsnrMYSVNGytfgsLSGLSMCAeDRVKWYLFGMGNEVD 293  human
2J5W_A     575 DKEFYLFPTVFDENESLllednirmfttapdqvdkededfqesnkMHSMNGfmygnQPGLTMCKgDSVVWYLFSAGNEAD 654  human
2R7E_A     193 LHKFILLFAVFDEGKSWhsetknslmqd------rdaasarawpkMHTVNGyvnrsLPGLIGCHrKSVYWHVIGMGTTPE 266  human
1KCW_A     195 DREFVVMFSVVDENFSWyledniktycsepekvdkdnedfqesnrMYSVNGytfgsLPGLSMCAeDRVKWYLFGMGNEVD 274  human
1KCW_A     894 KLEFALLFLVFDENESWylddniktysdhpekvnkddeefiesnkMHAINGrmfgnLQGLTMHVgDEVNWYLMGMGNEID 973  human
2R7E_A     570 DKRNVILFSVFDENRSWylteniqrflpnpagvqledpefqasniMHSINGyv-fdSLQLSVCLhEVAYWYILSIGAQTD 648  human
2R7E_B     311 VQEFALFFTIFDETKSWyftenmerncrapcniqmedptfkenyrFHAINGyimdtLPGLVMAQdQRIRWYLLSMGSNEN 390  human
NP_841583  214 DQEFIALYMIFNEENDEes------------------------glKHAINGrifgnLSGFETRRgQRVRWHLVALGNEVD 269  Nitrosomonas eur...
2J5W_A     913 KLEFALLFLVFDENESWylddniktysdhpekvnkddeefiesnkMHAINGrmfgnLQGLTMHVgDEVNWYLMGMGNEID 992  human
1SDD_A     180 EKQHVLMFAVFDESKSWnqt----------------------sslMYTVNGyvngtMPDITVCAhDHISWHLIGMSSGPE 237  cow
P12259     541 DIEQQAVFAVFDENKSWyledninkfcenpdevkrddpkfyesniMSTINGyvpesITTLGFCFdDTVQWHFCSVGTQNE 620  human
1SDD_B     189 MREFVLLFMVFDEKKSWyydkkptrswr------rassevknsheFHAINGmi-ynLPGLRMYEqEWVRLHLLNLGGSRD 261  cattle

Feature 1       #                                             #    #    #      
2J5W_A     294 VHAAFFHGQALTNKn---YRIDTINLFPaTLFDAYMVAQnPGEWMLSCQnLNHLKAGLQAFFQV 354  human
2J5W_A     655 VHGIYFSGNTYLWRg---ERRDTANLFPqTSLTLHMWPDtEGTFNVECLtTDHYTGGMKQKYTV 715  human
2R7E_A     267 VHSIFLEGHTFLVRn---HRQASLEISPiTFLTAQTLLMdLGQFLLFCHiSSHQHDGMEAYVKV 327  human
1KCW_A     275 VHAAFFHGQALTNKn---YRIDTINLFPaTLFDAYMVAQnPGEWMLSCQnLNHLKAGLQAFFQV 335  human
1KCW_A     974 LHTVHFHGHSFQYKhrgvYSSDVFDIFPgTYQTLEMFPRtPGIWLLHCHvTDHIHAGMETTYTV 1037 human
2R7E_A     649 FLSVFFSGYTFKHKm---VYEDTLTLFPfSGETVFMSMEnPGLWILGCHnSDFRNRGMTALLKV 709  human
2R7E_B     391 IHSIHFSGHVFTVRkkeeYKMALYNLYPgVFETVEMLPSkAGIWRVECLiGEHLHAGMSTLFLV 454  human
NP_841583  270 NHTVHWHGQTVLDHg---RRTDVVEIMPaSMTSVDMVPRsPGNWLFHCHvNDHMIAGMATRWLV 330  Nitrosomonas europaea ATCC 19718
2J5W_A     993 LHTVHFHGHSFQYKhrgvYSSDVFDIFPgTYQTLEMFPRtPGIWLLHCHvTDHIHAGMETTYTV 1056 human
1SDD_A     238 LFSIHFNGQVLEQNh---HKISAITLVSaTSTTANMTVSpEGRWTIASLiPRHFQAGMQAYIDI 298  cow
P12259     621 ILTIHFTGHSFIYGk---RHEDTLTLFPmRGESVTVTMDnVGTWMLTSMnSSPRSKKLRLKFRD 681  human
1SDD_B     262 IHVVHFHGQTLLENgtqqHQLGVWPLLPgSFKTLEMKASkPGWWLLDTEvGEIQRAGMQTPFLI 325  cattle

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