Conserved Protein Domain Family
eIF-2B_gamma_N

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cd04198: eIF-2B_gamma_N 
The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2.
N-terminal domain of gamma subunit of the eukaryotic translation initiation factor 2B (eIF-2B): eIF-2B is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, generating active eIF2.GTP complex. EIF2B is a complex multimeric protein consisting of five subunits named alpha, beta, gamma, delta and epsilon. Subunit gamma shares sequence similarity with epsilon subunit, and with a family of bifunctional nucleotide-binding enzymes such as ADP-glucose pyrophosphorylase, suggesting that epsilon subunit may play roles in nucleotide binding activity. In yeast, eIF2B gamma enhances the activity of eIF2B-epsilon leading to the idea that these subunits form the catalytic subcomplex.
Statistics
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PSSM-Id: 133041
View PSSM: cd04198
Aligned: 22 rows
Threshold Bit Score: 196.341
Threshold Setting Gi: 146450928
Created: 3-Mar-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_065098      3 FQAVVMAVGg--GSRMTDLTSs-----iPKPLLPVGNKPLIWYPLNLLEr--vGFEEVIVVTTrdvqkalcaefkm---- 69  human
P56288        39 FQAVVFAGF---GNSLYPLTGsd---alPKALLPIGNKPMLHYPLYWLEa--aGFTSAILICMeeaeahinawlrsgy-- 108 fission yeast
EAK89547      14 FKGVIFAGGs--GRMLGPLAKn-----iSKAMIPVCNKPMIWYPLSNLIq--hRIRDICIFCEeefensirkyisetfsn 84  Cryptosporidium...
AAW45625      19 FQAVILVGY---GENLYPFNQgtn--viSKALLPVGNVPIINCVIDWVLa--aGLLDILIIVPnafhdqiadhiaeaynk 91  Cryptococcus ne...
EAR84576       5 YQVVILAGGq--GTELYPLCEr-----fPKALLPVNNKPLIIYQLEKLEs--nGFTNVLILTSkntskieryikeyy--- 72  Tetrahymena the...
XP_829233     18 FDIVVFAGGk--APGLNPLCDn-----ePKPMLCICNRPMIWYCLSPWIk--aGCSTFFVCVNedyaalqsylcrefp-- 86  Trypanosoma bru...
EDK45184       3 FTAVILCGN---GKALFPFSEtrs-tglPKALIPVANKSILTYVLDWCFt--aSFSKILVVTSqesseqvqteidafqne 76  Lodderomyces el...
EAU91280      15 FLAVLIAGF---GNELLPLTSdhgdepyPKALLPVANKPLLEYILSWLEq--aGIKDVLLICPaihrpalyhhihsdvs- 88  Coprinopsis cin...
XP_001446558   5 YQAIILGGGqkaGSMLFPLCQd-----ySKSLLPICNKPMILYQLDLLEtagfGPQDILILLTknhqavadlvq------ 73  Paramecium tetr...
CAG79840       5 FKVFILCGQ---GKNMAPLSSvra-sgvPKALLPMANVPVIDYTLKWCEt--iPNPKVFVCCStadeaeisayvdsfka- 77  Yarrowia lipoly...
NP_065098     70 -----------------kmkpdivcipddADMGTADSLRYIYPkl----------ktDVLVLSCDLITDValhevv---- 118 human
P56288       109 --------------eghmrihveaptildDSKSSADALRAVSHliksqkmltdthqnDFVCLSCDSIVGLppiygldk-- 172 fission yeast
EAK89547      85 dtiikrfefeetyqqnikiiglkedesllESSGTWSILSEYGKefl--------rdsDFFVLTCDVIGPLdllgla---- 152 Cryptosporidium...
AAW45625      92 sthsr---vrinlrknsegerdedegdseEKDGTARILKKFRSfi----------ksDFVLLPCDISPPSylplktil-- 156 Cryptococcus ne...
EAR84576      73 ----------------qgqvkyelitipdEKKETFEAIRHVSNki----------nkDFILIACDSITDLglddvi---- 122 Tetrahymena the...
XP_829233     87 --------------kvafvfvlvpltqnqTPTTTCDVVRGYLKhkeslksdrlskprDALLLSCDTFLPGvdvehfi--- 149 Trypanosoma bru...
EDK45184      77 krlnl--sldlkdydksttsnvsidlmgiTADHSGEAIYNICTeskyk-----ietqNFIILSCDFITNLppqvliem-- 147 Lodderomyces el...
EAU91280      89 -------------spslridlqtyeetqeSPAGTCELLRHFSNri----------teDFVLVPCDFLAPPslplsqllnt 145 Coprinopsis cin...
XP_001446558  74 -------------------rraeifyvseDSESGSALLEAHEKik-----------kDFILLSCDSMIGAnildll---- 119 Paramecium tetr...
CAG79840      78 -------------ehstsvvasnvticskTDAKSGDFILELTRge----------psDFIVVGCDFITDIpasslvd--- 131 Yarrowia lipoly...
NP_065098    119 --dlfrayDASLAMLMrkgqdsiepvpg---------------------------------------------------- 144 human
P56288       173 frldnpsaLAVYSPVLkyehitsq-------------------------------------------------------- 196 fission yeast
EAK89547     153 --nkhrltQAVCTILLtespdlskikgsgkqtsnsnn------------------------------------------- 187 Cryptosporidium...
AAW45625     157 -dkhrsspKAVMTSVFyepiesv--------------------------------------------------------- 178 Cryptococcus ne...
EAR84576     123 --eqhiltGAYLTAVLkedkvdeennki---------------------------------------------------- 148 Tetrahymena the...
XP_829233    150 --hnfyasVASVSVLLfrpisssngnscgtqlgptargnsastpagsgkgnkgsqgsgacaakpythhftcvayeeksgd 227 Trypanosoma bru...
EDK45184     148 -frnrpsnQLGITVAYrnqldiedkk------------------------------------------------------ 172 Lodderomyces el...
EAU91280     146 frvestsdNNLLTTCWypvhvpdktvl----------------------------------------------------- 172 Coprinopsis cin...
XP_001446558 120 --dfhyskKATITCLIkeedldkkqgr----------------------------------------------------- 144 Paramecium tetr...
CAG79840     132 -tyrsrdsDSLLTAFYypntlenvdk------------------------------------------------------ 156 Yarrowia lipoly...
NP_065098    145 -------------qkgkkkaveqrdFIGVDSTGK-RLLFMANEADLDEElvi---kgsILQKHpriRFHTGLVDAHLYCL 207 human
P56288       197 -----------------skeidakqLIGIEEKTS-RLLYAKSSADVGSDftf---rmsLLWKHprvTLNTNLSDAHIFVF 255 fission yeast
EAK89547     188 ----qaqanpiggisvdlqkdknrsIFVIDEKDE-VILSIKDFYSAKQEnevselsklQLFWHpnvSLRTDLVDLHVYLF 262 Cryptosporidium...
AAW45625     179 ------------------kdaeekiLVGLDKTSD-ELLLITPLEGMEEDlel---rmsLLNRHptlSLTTRILDAHVYVF 236 Cryptococcus ne...
EAR84576     149 --------------inpsssadnhdVFLIDETNN-KILYVNSFYEIKENglki--kksILASNpeaSIKTNLFDSHIYIC 211 Tetrahymena the...
XP_829233    228 hvrndnnnngsalcpvasgvtensnKGSNCVSHH-RLHFICPREDEPEPcis----fgFAARRpnlTFAADVVDVHAYLV 302 Trypanosoma bru...
EDK45184     173 ----------------lkvfpkkytVYSDDSLMGsCLLDQYTKEDTDMSkvll-irskMCFTYpnsVISTKLLDSGIFMG 235 Lodderomyces el...
EAU91280     173 --------------sdewgpapsppAIVVDPATG-SLLHIDTPDDRDRNnedfqfsmgMISRFsrtKLTASFQDSHVYIC 237 Coprinopsis cin...
XP_001446558 145 --------------apiscnldesfDIMFIGSDQ-SLLHITSQEDDDQVnlqv-srnvLLSCQs-vQIMTNLFDTHVYVC 207 Paramecium tetr...
CAG79840     157 ----------------ksllkdvtvHSSLDSRTP-RLLDSYSRDYIENKktmp-irrsMLWHFpksLVSTQLLNASVYFC 218 Yarrowia lipoly...
NP_065098    208 KKYIV 212 human
P56288       256 KHWVI 260 fission yeast
EAK89547     263 KSSIF 267 Cryptosporidium parvum
AAW45625     237 RRTFL 241 Cryptococcus neoformans var. neoformans JEC21
EAR84576     212 KRQIL 216 Tetrahymena thermophila SB210
XP_829233    303 RNWVL 307 Trypanosoma brucei TREU927
EDK45184     236 SREIF 240 Lodderomyces elongisporus NRRL YB-4239
EAU91280     238 QNKIL 242 Coprinopsis cinerea okayama7#130
XP_001446558 208 QYEVL 212 Paramecium tetraurelia
CAG79840     219 TADVC 223 Yarrowia lipolytica CLIB99
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