1JV1,2YQC


Conserved Protein Domain Family
UDPGlcNAc_PPase

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cd04193: UDPGlcNAc_PPase 
Click on image for an interactive view with Cn3D
UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc.
UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1 to PPi and UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc), the activated form of GlcNAc, is a key precursor of N- and O-linked glycosylations. It is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker which anchors a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis. Human UAP has two isoforms, resulting from alternative splicing of a single gene and differing by the presence or absence of 17 amino acids. UDPGlcNAc pyrophosphorylase shares significant sequence and structure conservation with UDPglucose pyrophosphorylase.
Statistics
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PSSM-Id: 133036
View PSSM: cd04193
Aligned: 24 rows
Threshold Bit Score: 380.413
Threshold Setting Gi: 84999118
Created: 28-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
substratedimerization
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                            # ##                                                        
1JV1_A        88 QAWESEGLFQISqnkVAVLLLAGGQGTRLGVAYPKGMYDVGlps-rktLFQIQAERILKLQQVAekyy------------ 154 human
NP_225051     85 PERAHAGTTLLKekkVACVVLAGGQGSRLKCDGPKGLFPVSpik-kkpLFQLVAEKVRAASKLAg--------------- 148 Chlamydophila p...
EAN79223      95 KNLEAVGYKAIQkgqIAFLILAGGSGTRLGFDKPKGFFTCDglqqrksLFMMHCEKIRRRQEIAesisg----------- 163 Trypanosoma brucei
CAJ71271      96 EKAKQVGEESLCngeIAILTVAGGQGTRLGIDGPKGMLPISpin-kksIFQLHAEKIRALQTKYn--------------- 159 Candidatus Kuen...
XP_001032038 185 NELQLLGLEAIAkgeVAVILLAGGQGTRLGYDKPKGMLTLEvps-krtIFSYYADKIKTLSNYAlskfpqykke------ 257 Tetrahymena the...
XP_001454514  81 QQYQKLGEKLISegkVCVAMMAGGQGTRLGFNKAKGMFDIGlps-hktLFQIFCERILSLQNMIqsri------------ 147 Paramecium tetr...
CAG43880      79 KRLEEQGLQAIKegqFAVLLMAGGQGTRLGYKGPKGSFEIEgv----sLFELQANQLKTLNHQSg--------------- 139 Staphylococcus ...
CAD75108      96 EDAQKRGEEALRageIATVLVAGGQGTRLGFDQPKGMFPVGpvs-ertLFQFFADRLIAAGEKYg--------------- 159 Rhodopirellula ...
CAJ06693     104 AAIRAAGMRVVAsgeGAVLLMAGGSGTRLGMTIPKGMVECDklvsgrsLFAYHCQRIRKMERMAaaaaaslsqpsavaaa 183 Leishmania major
EDP25918      75 DTYLNAGIDTIKngdLALVLLAGGQGTRLGFSGPKGTFNVGvtk-dmfIFQLLIEHTLDIVKLAd--------------- 138 Coprococcus eut...
Feature 1                          #                              #                        # ##  
1JV1_A       155 --------gnkcIIPWYIMTSGRtMESTKEFFTKHKYFGLKKENVIFFQQGMLpam-sfDGKIILEEKNKVSMAPDGNGG 225 human
NP_225051    149 -----------qPLPLAFMTSPLnTRQTRSFFESNDYFHLDPNQVDFFCQPLWpll-tlSGDLFLEDMDTLALGPNGNGC 216 Chlamydophila p...
EAN79223     164 -------sgrkaRVQLLVMTSGQnDAETQRFFEENSYFGLEREQVHFFAQSSVpcydenTGRIIMENRGRICAAPGGNGA 236 Trypanosoma brucei
CAJ71271     160 -----------aMFPWYIMTSETnDHDTQEFFRSNKFFGLDQQRVYFFTQRMIptv-dmNGKILMNAKSNIVMSPNGHGG 227 Candidatus Kuen...
XP_001032038 258 ---ndahgrqriPIQFYLMTSVVtDQDTKDYFKANDYFGISEDSIHYFVQGYLpsl-dkKGKILFESKNKIFLSPNGNGG 333 Tetrahymena the...
XP_001454514 148 --------gqclPIQFFIMTSDVnHEETTQFFIENNYFNLQSDQITFFQQDSLpil-siNGEIMLSNSTAILEGPDGNGG 218 Paramecium tetr...
CAG43880     140 -----------hTIQWYIMTSDInHEETLAYFEAHSYFGYDQEAIHFFKQDNIval-seEGKLILNQQGRIMETPNGNGG 207 Staphylococcus ...
CAD75108     160 -----------vDVPLYLMTSEAtHVETRRYFEENNYLGLKPEQVTIFQQGTMpavdaeTGQVLLAEKGSLALSPDGHGG 228 Rhodopirellula ...
CAJ06693     184 gaapvppgagrgTMPLLVTTSDQnDTATRQFFHDHDFFGLLPNQVFFSRQSSLpcydeaTGRVLMQARGSICLAPGGNAG 263 Leishmania major
EDP25918     139 -----------tWIHFFIMTNEKnHDDTTTFFKEHNYFGYNPDYIHFFKQEMVpsv-dfNGKIYLEEKGRIAMSPNGNGG 206 Coprococcus eut...
Feature 1                                               ##                                    ## 
1JV1_A       226 LYRALAAQN--------------IVEDMEqRGIWSIHVYCVDNILVKVADPRFIGFCIQKgaDCGAKVVEKtnPTEPVGV 291 human
NP_225051    217 IATLLYTSG--------------VWEKWKnAGIEMVSVIPIDNPLALPFDVELCGFHAMSnnEVTIKAALRqtAIEDVGI 282 Chlamydophila p...
EAN79223     237 VFAALAAPRatkdkdgtlqvkesLLQHLRkLGIAYVQIGNIDNLLANVADPVFIGYAIEEeaHVVVKTCPKrgPDERVGV 316 Trypanosoma brucei
CAJ71271     228 TIIALQEKS--------------IINDIKeRGVRHIFYHQVDNVLIKMADPVFIGYHLMDgaDVSSKVVKKrsPDEKVGV 293 Candidatus Kuen...
XP_001032038 334 IYDSLQSTG--------------VLKKLNdQKIKYIQMMGVDNILGKFADPEQIGLMVKKgyEIVSKYAKKrnAAESVGI 399 Tetrahymena the...
XP_001454514 219 IFSSLYNQG--------------YLDYMKcLGIKYIHICPVDNALCKLCDPIWIGYVESKnlTICSKFVKKahAEEKVGI 284 Paramecium tetr...
CAG43880     208 VFKSLDKAG--------------YLEEMSnNGVKYIFLNNIDNVLVKVLDPLFAGFTVEHdyDITSKTIQPk-PGESVGR 272 Staphylococcus ...
CAD75108     229 TLRALSRNG--------------CMEEMRkNGRKHLFYFQVDNPLVGLCDPVFIGHHLLAssEMTTQVIRKryPTEKVGN 294 Rhodopirellula ...
CAJ06693     264 VYESLAKASatts------gsqsVLAQIEaRGVRYVQIVSVDNILARVGDPYFFGVAASYqaEVVLKTVPKvsAAEKVGV 337 Leishmania major
EDP25918     207 WFSSLCKAG--------------HLSKLTeHNIKYINVFSVDNVLQRIADPVFLGAVIKEgyLSGGKVVRKayPDEKVGV 272 Coprococcus eut...
Feature 1                     ##                       #                                         
1JV1_A       292 VCrv--dGVYQVVEYSEISLAtaqkr-ssdgrLLFNAGNIANHFFTvpFLRDVVNvyep---qlqHHVAQKKIPyvdtqg 365 human
NP_225051    283 LVkshdsGKTSVIEYSEIPQNerfal-nedgkLKYCLANIGLYCLSmdFIRHAAYqqlp---lykVHKHAKQLGhts--- 355 Chlamydophila p...
EAN79223     317 FVra--sGKWGVVEYTEIGDRakeid-datgeLKFNCANISSNLCSlhFMSLAAErmks---ftqYHAARKKIPtik--- 387 Trypanosoma brucei
CAJ71271     294 IVsl--dGHLHVVEYSELSQEdkyak-nndgtLKYNAGNIAIHIFSiaFLEKLFQmet----ylpYHIAIKKVPfidlng 366 Candidatus Kuen...
XP_001032038 400 HVlr--dKKFSIMEYSDMTEAqknkv-dangkLVYDKSFLCNFFCSidFLNRIINdenakkelfqYHLANKQVAyydvdl 476 Tetrahymena the...
XP_001454514 285 HAli--nEKPCVIEYSEMTQEdlhkk-neegeLIYDAGGIAQMICTveFAHKIIEdpqt---snnYHVAQKKYDyyninq 358 Paramecium tetr...
CAG43880     273 LVnv--dCKDTVLEYSELDPEv---------aNQFNNANIGIHAFKlgFILNAVNre------lpYHLAIKNLKqlden- 334 Staphylococcus ...
CAD75108     295 VVei--dGQTQIIEYSDLPDSaaemt-nadgsLKLWAGNIAVHLFDldFLERMLDldt----slpIHRANKKVShvvadg 367 Rhodopirellula ...
CAJ06693     338 VAqv--dGEWAVVEYTEIGDRrsaetdpatgeLAFNCGSIASHCCSldFLALAATymet---stfYHAARKTIPtin--- 409 Leishmania major
EDP25918     273 LCtn--hGKPYIVEYYELTDEmrnqr-dengdYAYNYGVTLNYIFPvdRLMKIMNes------mpLHIVKKAIPyvdkng 343 Coprococcus eut...
Feature 1                          #                                       #   
1JV1_A       366 q-likpdkPNGIKMEKFVFDIFQFa----------------kKFVVYEVLREDEFSPLKNAD 410 human
NP_225051    356 -----lneKNAWKFEEFIFDLFCYs----------------dHCQTLVYPRQECFAPLKNLE 396 Chlamydophila pneumoniae CWL029
EAN79223     388 ------gpVMGIKLEAFLFDLFRFvdecdh------ppkdsgAFRIMQVDRDDEFGPVKNAD 437 Trypanosoma brucei
CAJ71271     367 n-litpkeNNAIKFETFIFDVLKHv----------------kNGVLMEVIRKEEFSPVKNAE 411 Candidatus Kuenenia stuttgartiensis
XP_001032038 477 kqvvkpaeKNAYKFELFIFDSFPLa----------------kTFCLMEINREEQFAPIKNSV 522 Tetrahymena thermophila SB210
XP_001454514 359 rqivkpdqINALKFELFFFDCFPLcp--------------keQFGLIEVKREDEFAPVKNAP 406 Paramecium tetraurelia
CAG43880     335 ---fgvieQPTLKFELFYFDIFTYg----------------tSFVTLQVPREEEFSPLKNKE 377 Staphylococcus aureus subsp. aure...
CAD75108     368 q-lvtpesPNATKFEQFIFDLLPNa----------------kNTIVCEANPAEAFAPVKNAN 412 Rhodopirellula baltica SH 1
CAJ06693     410 ------gpAPAIKLEAFIFDVFRYakdvpsraerakkaplpdALQILQVDRSMEFAPIKNAD 465 Leishmania major
EDP25918     344 d-ivkpaePNGYKFETLALDMIAFm----------------gTCLPFEVEREKEFAPIKNAT 388 Coprococcus eutactus ATCC 27759

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