Conserved Protein Domain Family
G1P_TT_long

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cd04189: G1P_TT_long 
G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase.
This family is the long form of Glucose-1-phosphate thymidylyltransferase. Glucose-1-phosphate thymidylyltransferase catalyses the formation of dTDP-glucose, from dTTP and glucose 1-phosphate. It is the first enzyme in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme.There are two forms of Glucose-1-phosphate thymidylyltransferase in bacteria and archeae; short form and long form. The long form, which has an extra 50 amino acids c-terminal, is found in many species for which it serves as a sugar-activating enzyme for antibiotic biosynthesis and or other, unknown pathways, and in which dTDP-L-rhamnose is not necessarily produced.The long from enzymes also have a left-handed parallel helix domain at the c-terminus, whereas, th eshort form enzymes do not have this domain. The homotetrameric, feedback inhibited short form is found in numerous bacterial species that produce dTDP-L-rhamnose.
Statistics
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PSSM-Id: 133032
View PSSM: cd04189
Aligned: 26 rows
Threshold Bit Score: 301.795
Threshold Setting Gi: 51891915
Created: 17-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:substrate binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             # ##                                                                       
NP_142397      5 MKALILSGGYGTRLRPLTYSQQKQLIPVANKPVLFYAIEDVIEAGIHEIGIVVGp-nADLVKKTVmsvd-wdanIEFIYQ 82  Pyrococcus hori...
NP_285355     10 MKALIPAAGLGTRLRPLTFTRPKPVLRVAGQPIIRHAIRTLTEAGITDIGIVVSdvtRDEIQHAVreir--dvkLTLINQ 87  Deinococcus rad...
NP_147764      2 VKGLILAAGEGSRLRPFTFSRPKHLIPLLGKPIIQYAIDDLVSINVRDIGVVVGy-fGDKIKEFLgedsrfgakFTYIVQ 80  Aeropyrum perni...
CAF18473       1 MFGLVLAGGEGSRLRPFTFSTPKHLIPLLGRAMIEYPIVHLAEAGVSEVGVVVGy-mGHLIQEHLgdgsrlgvrVRYFWQ 79  Thermoproteus t...
YP_074606     10 VRALVLCASRGTRLRPLTHTWAKASLPVAGRPIWQHIFSYLAAHGFDEIGVVVGp-gQEELARSVkrws--pqrVTVILQ 86  Symbiobacterium...
BAB60061       3 MKGIILHGGSGTRLRPLTYTDVKQLLPIAGKPISEYALENLIEIGIKNINIVIGsvgGLEVKKFYgdgsrwnvnISYTYQ 82  Thermoplasma vo...
YP_603664     21 MKGVILAAGRGSRLFPVSAGRPKHAVPIAGVPIIAWAVRAVREAGVEEVAVVTSsnnEAALREATrde----gpLTFLRQ 96  Deinococcus geo...
ZP_02845455    1 MKGLILCAGKGSRLYPFTKNRPKTLIPVTNTPLLQLSIMKLMELGIDRIGIVIHpsqEADIRAQFgegeafgisITYIYQ 80  Paenibacillus s...
YP_001434879   1 MEGIILAAGKGSRLRPLTLTVPKPLIPVAGKPLVQYGIEQLRGVGVERAVVVVGw-lGELFKEVLgdgsalgmrFEYVLQ 79  Ignicoccus hosp...
YP_001541289   1 MLGLILVAGIGERMRPLSYSIPKPLISILGKPLVAYTMDKLKDIDVSRIGLVVGr-fSELFMDYFnndprlnipVTYIRQ 79  Caldivirga maqu...
Feature 1         #  ##                      #                                  #               #
NP_142397     83 GEPkGLAHAILVARDylg-dedFVMYLGDNILRegivrhkehfeksdyDASILLCEVPNPQQFGVAELsedgktiKRLVE 161 Pyrococcus hori...
NP_285355     88 HDQlGLGHAVLTAREwvg-qddFCVYLGDNLFEfgarpfiesfhqkhpAALIALVKVADPTAFGVAELdge--qiTRLVE 164 Deinococcus rad...
NP_147764     81 KKRlGIAHAIYRAIKqgfidkeFIVYLGDNILSggisrhvkswgeagsEVHILLTKVRDPGRFGIAVLrdg--kiLKLVE 158 Aeropyrum perni...
CAF18473      80 ERRlGIAHAISLALPeik--gpFVVYLGDNILAggikrhvraflegdfDVYILLARVPDPSRFGVAVLrdg--rvVRLVE 155 Thermoproteus t...
YP_074606     87 AEPaGIAHAVAAARPfla-dqpFLLYLGDNLTNadlgpalrrfraeapSALITLQRVADPRTFGVAVLdgg--rvTAVAE 163 Symbiobacterium...
BAB60061      83 PEPlGIAHAIGLTKAfvg-nddFVVFLGDNYLQngisnlyedftnagsDGHLGLVPVDNPSQFGIAEVdng--kiSKLVE 159 Thermoplasma vo...
YP_603664     97 EEPrGTGDAVLAARAfle-gspALLYLGDNLFAdpltplt--ealqdaDAALGVKQVPDPSAYGVAAVrdn--llTNLDE 171 Deinococcus geo...
ZP_02845455   81 HAPkGIANALKNAEYyls-gepFLLLLGDNLISaplsdlkydvehggvQASLLLAEVADPQDYGIAEIqds--riIGLEE 157 Paenibacillus s...
YP_001434879  80 PKRlGVAHAIHTAIVnanvrspFLVYFGDNVFDdewvkkf-nsvdeefDAFVVLAKVEDPRRFGVPVIesg--riVKFVE 156 Ignicoccus hosp...
YP_001541289  80 ERRlGIAHAIYRGIEegflredFVVALGDNYFSesftrfarefleggyDVFIVLTRHQQFQRFGNAVVegg--rvVRLIE 157 Caldivirga maqu...
Feature 1        #                                        #                                      
NP_142397    162 KPKHPP-SNLALVGIYFFR--PIIHEAVRhIKPSWRNELEITDAIQWLIDnGYKVGWTKvtGWWKDTGKPEDLLEANRLV 238 Pyrococcus hori...
NP_285355    165 KPKDPP-SNLAVAGLYCFT--PQIFEVLDvMPPSARGEYEITDGIQGLIErGQTVVGQRveGWWKDTGRPADLLDANRLL 241 Deinococcus rad...
NP_147764    159 KPQEHI-SDLAVVGVYMFRdpELVAKAFStLKPSWRGEYEITDLIQWFVDkGYKVTFSLvtGWWKDVGTYEGLLDAIYLL 237 Aeropyrum perni...
CAF18473     156 KPREPV-SDLAVVGVYMFRdpEDVARAFSsLKPSWRGEYEVTDLIQWFIDrGRRVGFDFvdGWWKDVGTPEGLLEAVYLL 234 Thermoproteus t...
YP_074606    164 KPAEPT-SDLAIAGIYFFS--PEVHAAIAgLTPSARGELEITDAIARLIAgGRIVLGHElsGWWVDAGTAAGLLAANARL 240 Symbiobacterium...
BAB60061     160 KPKTPT-SNLAIVGVYFLT--PKVFESIDrLKPSKRGEYEITEAYQDMIDrGLKISYSIisGWFKDTGTVDDFLACNRLI 236 Thermoplasma vo...
YP_603664    172 KPAAPA-SDLAACGVFAFH--PHVLEEVArLEPSVRGEIEFPQALLRVIAaGGRVRAVTfpGFWSDAGTPADLLSASAHF 248 Deinococcus geo...
ZP_02845455  158 KPVHPK-SNLAVIGGYAFT--KEIFGAVNkITPSKRGEYEITDAIQWLIEqRYDVAYRVtdQLNIDVGTKDRWLLANRKL 234 Paenibacillus s...
YP_001434879 157 KPERPP-SNYALTGLYAFRdpEQYESCFSeLKPSWRGEYEITDLLNCYIRrGYDVKYAVveGWWKDTGVPEDLIEAMKFI 235 Ignicoccus hosp...
YP_001541289 158 KPNQPIpNSYVVTGLYFFRdpDAVAKAFSnLRPSARGEYEVTDLIQWFIDnNYRVGYSLttGWWKDMGTPEDLIDLVQLM 237 Caldivirga maqu...
Feature 1           
NP_142397    239 LDE 241 Pyrococcus horikoshii OT3
NP_285355    242 LEQ 244 Deinococcus radiodurans R1
NP_147764    238 LDN 240 Aeropyrum pernix K1
CAF18473     235 LDH 237 Thermoproteus tenax
YP_074606    241 LEA 243 Symbiobacterium thermophilum IAM 14863
BAB60061     237 LDK 239 Thermoplasma volcanium GSS1
YP_603664    249 LSK 251 Deinococcus geothermalis DSM 11300
ZP_02845455  235 LEA 237 Paenibacillus sp. JDR-2
YP_001434879 236 LEK 238 Ignicoccus hospitalis KIN4/I
YP_001541289 238 LDD 240 Caldivirga maquilingensis IC-167

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