Conserved Protein Domain Family
GT2_RfbC_Mx_like

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cd04184: GT2_RfbC_Mx_like 
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis.
The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.
Statistics
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PSSM-Id: 133027
View PSSM: cd04184
Aligned: 36 rows
Threshold Bit Score: 249.427
Threshold Setting Gi: 107021960
Created: 6-Dec-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:Probable Catalytic site
Evidence:
  • Comment:Residues conserved among GT families of 2, 7, 13 and 43

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                                         
YP_872484     210 PTISVLVPVHNaaerWLRRCIDSVLAQSYPYWQLCLADDASSAPHVRQvleeyaarDARITAIFRpvnGHISAASNSALD 289  Acidothermus ...
YP_746211     417 VRLSIVMPVYNtpqdWLIEALNSVRAQWCDNWELLCINDASSEPHVETilrayaqqDPRIRILRTgnnVGIARATNFGLR 496  Granulibacter...
ZP_01772638   289 PLVSIVVPCYKtdrvYLRELLDSVLAQSYDNWELLLMDASPEWDAVADlaa--gahDERVRRFGLpgnGGIVVNTNAGIE 366  Collinsella a...
AAM38441       85 GMISVIIPVCNtpelFLREAIESVRTQTYQNWEICIHDDASNEPHVGRilaefkkrIPNLRVTRSetrSGIAATTNAALA 164  Xanthomonas a...
BAB76186      478 PVLSIILPVYKlpltVLQETINSVIQQTYSNWELCIAFADIDNYQTIDylktlslqEKRIKLKVMaenKGISGNSNVSLN 557  Nostoc sp. PC...
YP_828145     121 PLVSLIMPVYQpnleWLMAAVKSVRTQTYDDWQLLIVLDGGPSREVLNylqp-lasEDPRIQCLFsdrGGISSTLNLGLS 199  Solibacter us...
ZP_01468902   681 SVISFIVPIFKtpllYLQQLLSSVQSQSYPNWELCLGGGDLDQDVLSYlnykmlsdHRIKYIEVNsseQGISVNSNAAIS 760  Synechococcus...
Q50864        319 PLISLVTPVHDaseaFLRECLASVSSQVYADWEWLLVDDASTAPHLARilreaaerESRIRVLTAsseGDTARATNEGFA 398  Myxococcus xa...
YP_001213130   77 PLISTILPLANieikYLEQTLNSVLRQAYPCWELCAVATDKINPYVIEiykkyqsiDDRFRLSFIsfnSGVVQVANAALS 156  Pelotomaculum...
ZP_02087323   182 PMLSVVIPAYKtperYLREMLDSIMEQTYTNWEICVADGSPRGEGLERvlkkyadrDRRVRYEILgsnRGISGNTNAALD 261  Clostridium b...
Feature 1                    ##                                                                   
YP_872484     290 AAQGDFIALLDHDDELAPDALLHvaall---nehpdADMIYSDEDKin-edGVRQEPFFKPDWSPELLLSh-mYTCHLGV 364  Acidothermus ...
YP_746211     497 AASGQYVTFMDHDDYLEPDAVYHllkaa----getqADFIYSDEATtdeniASIAEVRGRPAFSHDYYLSh-pYIVHMLC 571  Granulibacter...
ZP_01772638   367 QAMGDYIAFLDHDDILEPDALFHyvaalnnaaegerPQVLFCDEDMfq-ktGEWGQPVFKTKLNVDLLYSh-nCVTHFLM 444  Collinsella a...
AAM38441      165 SARGRWVTFLDHDDVLDRNALAAvvdch----iktgSAVVYTDHDMlg-edGRLRNPYFKPDWNYDLFLAq-mYLGHLVS 238  Xanthomonas a...
BAB76186      558 MASGEFVALLDHDDLLAPFAFYEvisel---nkqpdLDFIYSDKDCis-anSMVRSRLLLKPEWSPEILYsanYLTHLCI 633  Nostoc sp. PC...
YP_828145     200 VCSGGYAAFIDQDDTLEPTALAHvaaai----thdePDIIYTDEDYvd-erGAAHLPLFKPAWSPALLFSc-mYFGHLIV 273  Solibacter us...
ZP_01468902   761 ICTGKYIALLDHDDLLSANCALEiisih----eendCDFVYTAEDKvdgtgLNFYGPVYKNVYSEEKLLKn-nYITHLSS 835  Synechococcus...
Q50864        399 ACRGDFVGFLGAEDTLSPHALAEvalaf---laqpeLALLYTDEDGld-aqGHRSAPFFKPDWSPDLLRSv-dYVRHFLV 473  Myxococcus xa...
YP_001213130  157 MCVGEFVGFLDCGDELAPHALLEivkll---nrepkIDAIYTDEDRln-nkNKRSRPLFKPGWSPDLLLSm-nYVGRYLA 231  Pelotomaculum...
ZP_02087323   262 MARGDFVILADHDDTLPPNAFYEvvkai---nenpdCQVIYSDEDKldmdgKALFDPHFKPDFNPDLLTSv-nYICHLFV 337  Clostridium b...
Feature 1                             #                          
YP_872484     365 YRTELVRRIGGFrlgfegSQDYDLVLRLteqtdrIYHIPRVLYHWRR 411  Acidothermus cellulolyticus 11B
YP_746211     572 LKRELAHQLGGWdesmaiSADVDFVLRIiehartIAHVPRVLYRWRT 618  Granulibacter bethesdensis CGDNIH1
ZP_01772638   445 VEKALIDRIGTSpedvagAQDYDLTLRClaagarFEHVAHVLYHWRV 491  Collinsella aerofaciens ATCC 25986
AAM38441      239 FEHDLIKRVGLTrsecdgSQDYDLVLRCvaagakVGHVPRVLYHWRM 285  Xanthomonas axonopodis pv. citri str. 306
BAB76186      634 ARRTLLEKIGGFrpetdgAQDWDLFLRItentsrIARINSVLYHWRI 680  Nostoc sp. PCC 7120
YP_828145     274 VNTERARKIGGFrtaydgAQDYDFVLRLtdedarVVHIPRVLYHWRR 320  Solibacter usitatus Ellin6076
ZP_01468902   836 FSRELIKEIGGFrpeydgAQDYDLILRAsshakkIFYLPRVLYHWRV 882  Synechococcus sp. BL107
Q50864        474 VRRETLAQVGGLregfdgAQGHDLMLRLseatssIGHITEPLYHARE 520  Myxococcus xanthus
YP_001213130  232 VRKSLLDKLNGFredvegVHYHDMLLRLseltknIVRLPEVLYHRRS 278  Pelotomaculum thermopropionicum SI
ZP_02087323   338 IRQDLLKQVGGFrqefdgAQDYDFIFRCteaakrVYHIPKVLYHWRC 384  Clostridium bolteae ATCC BAA-613

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