1H5R,1G97,1LVW,2GGO,2PA4,1TZF


Conserved Protein Domain Family
NTP_transferase

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cd04181: NTP_transferase 
Click on image for an interactive view with Cn3D
NTP_transferases catalyze the transfer of nucleotides onto phosphosugars.
Nucleotidyltransferases transfer nucleotides onto phosphosugars. The enzyme family includes Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase. The products are activated sugars that are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides.
Statistics
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PSSM-Id: 133024
View PSSM: cd04181
Aligned: 159 rows
Threshold Bit Score: 134.245
Threshold Setting Gi: 15897314
Created: 14-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:
  • Structure:2pa4_a; Udp-Glucose Pyrophosphorylase FromCorynebacteria Glutamicum In Complex With Magnesium And UDP-Glucose.
    View structure with Cn3D
  • Comment:Active site with UDP-glucose and two Mg++ molecules bound

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ####             ##                                                        # 
1H5R_A         6 GIILAGGsGTRLYPvtmavSKQLLPiyDKPMIYYPLSTLMlagirDILIISTpqdTPRFQQLLgdgsq-wglnLQYKVQP 84  synthetic const...
AAM06398       3 AVVLVAGkGTRMEPltsdcPKVMLKvaNKPILEHILNSAIeagieGFIFITGy-lEEQIKAHFgdgsk-wevsIEYVQQK 80  Methanosarcina ...
CAI82693       3 AVILAAGeGSRMRPltftrPKVMLPiaGKPILEHLLMEVSaagikEFVLVVGy-rDEQVRSYFadgak-wgvkISYCQQT 80  Dehalococcoides...
AAB86062       3 AVILTAGeGTRMRPltltrPKTMLPvaGKPILQYSVDALRdngvhDIVMITGy-hEEAVRSHFgdgsg-sgvnITYVRQE 80  Methanothermoba...
YP_001273228   5 AIILSAGeGSRMRPltltkPKTMLPvaGKPIIQYNIESLRdngitDILLIVRy-kEEIVRNYFgdgsd-fgvnISYKTQK 82  Methanobrevibac...
2GGO_A         3 AFILAAGsGERLEPithtrPKAFVPilSKPLIEYQIEYLRkcgirDITVIVSsknKEYFEKKLk--------eISIVTQK 74  Sulfolobus toko...
NP_342250      3 AVVLAAGkGERLEPithtrPKPFVPvlETPLILRHIRILKkyinkIIIVINSn-hKDYFKTIEg---------VSLVEQT 72  Sulfolobus solf...
YP_001040857   4 AIILAAGkGLRLRPitetrPKPLIPvlCKPLLQWQLEALAginevDEVVIVVsylKEQVEQFVgkln--mpfkITLLDQG 81  Staphylothermus...
ZP_02192499   31 ALILCAGkGTRLRPltdntPKPMIPiaGKPIVVHLVDKIKds-vnNIYILVGy-qKEAIINYFtsneeyynynIQFIEQI 108 Methanococcus v...
Q58501         3 AIILCAGkGERLRPltenrPKPMIPiaGKPILQHIIEKVEdl-vdNIYLIVKy-kKEKIVDYFknh-----pkIKFLEQG 75  Methanocaldococ...
Feature 1                                        # ##                                            
1H5R_A        85 sp-dGLAQAFIIGeefi-------ggddCALVLGDNIFyghdlpklmeaavnkesGATVFAyhvndperYGVVEfdkngt 156 synthetic const...
AAM06398      81 eq-lGTANAIGYArghv--------egaFLVLNGDMLIeqedlka----lvsreeEAVICVkevenpsdFGVLEten-dk 146 Methanosarcina ...
CAI82693      81 rq-lGTAHALKQLenql--------egnFLVMNGDILAesadis-----alaagsETTLSVlevsdpssLGVLEtdg-dr 145 Dehalococcoides...
AAB86062      81 er-lGTAHAIGQAseli--------ddeFIVLNGDIITdpglmgdligsyherkpETLMVLrevpdpssFGVVKveg-dr 150 Methanothermoba...
YP_001273228  83 df-lGTANAISYGedfi--------ddsIIVLNGDIILddeiiheiikkynylspDTLMLLtevedpsaFGVVEien-gn 152 Methanobrevibac...
2GGO_A        75 ddikGTGAAILSAkfn----------deALIIYGDLFFsnekeic----niitlkENAIIGvkvsnpkdYGVLVldnqnn 140 Sulfolobus toko...
NP_342250     73 eg-kGTAAALRAAekyle------gdeeFLVIYGDLLFeedald-----kivnteGEAILAresedprkFGVIVkdsenr 140 Sulfolobus solf...
YP_001040857  82 ee-lGTGDAILKAirkr-------gidgKILIIYGDIFlkdwnel---kqlvltrKDFIVGvevdnpsdYGVIVvdeyns 150 Staphylothermus...
ZP_02192499  109 kq-lGTGHAVLMLkeylesnnaledlndFLVINGDIVFednlndfi--nediddsKNYMGAlrvpnpenFGVILtdndnn 185 Methanococcus v...
Q58501        76 ei-dGTGQAVLTAkdyv--------ddeFLVINGDIIFeddle-------eflkyKYAVAVkevknpenFGVVVlddenn 139 Methanocaldococ...
Feature 1                             #                                                         
1H5R_A       157 aISLEEKPlepk-----snyaVTGLYFYDn-DVVQMAknlkpsargeleITDINRIYleq-grLSVAMmgrgyAWLDTG 228 synthetic construct
AAM06398     147 vVRIIEKPknpp-----tnlaNAGIYLFRe-SIFDFIdktqpsvrreleITDSIQMLins-gaPVGYSsl-egRWIDIG 217 Methanosarcina a...
CAI82693     146 vRCIHEKSanpp-----anlaNAGLYLFTp-RIFKAIsdtplsprgeyeITSSIQLLidn-gtEVGYRrl--vYWQDVS 215 Dehalococcoides ...
AAB86062     151 vREIIEKPgpdag---agnliNTGIYVFSp-AVFDYIertplsrrgeyeITDTIMMQvrddlpVRAIIsd--rDWIDVG 223 Methanothermobac...
YP_001273228 153 iKNIVEKPkreea---psnlvNAGIYIFNk-DIFDKIreteisergeyeITDSVSLQiednktVIGHKts--kDWIDVG 225 Methanobrevibact...
2GGO_A       141 lSKIIEKPeipp-----snliNAGIYKLNs-DIFTYLdkisisergeleLTDAINLMakd-hrVKVIEye--gYWMDIG 210 Sulfolobus tokodaii
NP_342250    141 lVRIVEKPenpp-----sniiNAGIYKFTy-DIFSYIdkislssrgefeLTDAVNLIgn---kVKVVTyn--gIWLDIG 208 Sulfolobus solfa...
YP_001040857 151 fKGIIEKPaipp-----snliNAGLYFLDarDILKHSdielsp-rgeleFTDILSSMarngveIKVYQls-kgKWIDIG 222 Staphylothermus ...
ZP_02192499  186 iLKIVEKPskeelpslnsnlvNAGIYRFKk-DIFDILkdlkpslrneieLPDAIDELils-hkIKAITin--gYWDDIG 260 Methanococcus vo...
Q58501       140 iIELQEKPenpk-----snliNAGIYKFDk-KIFELIektkisergereLTDAIKHLike-ekVKGIKln--gYWNDVG 209 Methanocaldococc...

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