1JV1,2ICY


Conserved Protein Domain Family
UGPase_euk_like

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cd04180: UGPase_euk_like 
Click on image for an interactive view with Cn3D
Eukaryotic UGPase-like includes UDPase and UDPGlcNAc pyrophosphorylase enzymes.
This family includes UDP-Glucose Pyrophosphorylase (UDPase) and UDPGlcNAc pyrophosphorylase enzymes. The two enzymes share significant sequence and structure similarity. UDP-Glucose Pyrophosphorylase catalyzes a reversible production of UDP-Glucose and pyrophosphate (PPi) from Glucose-1-phosphate and UTP. UDP-glucose plays pivotal roles in galactose utilization, in glycogen synthesis, and in the synthesis of the carbohydrate moieties of glycolipids , glycoproteins , and proteoglycans . UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1P from PPi and UDPGlcNAc, which is a key precursor of N- and O-linked glycosylations and is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker anchoring a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis.
Statistics
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PSSM-Id: 133023
View PSSM: cd04180
Aligned: 4 rows
Threshold Bit Score: 322.968
Threshold Setting Gi: 116668103
Created: 17-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ####          #                                            #               
1JV1_A    103 VAVLLLAGGQGTRLGVAYPKGMydvglpsrktLFQIQAERILKLQQvaeky--ygnkcIIPWYIMTSGrtMESTKEFFtk 180 human
2ICY_A     80 LVVLKLNGGLGTTMGCTGPKSVievr--dgltFLDLIVIQIENLNNky--------gcKVPLVLMNSFntHDDTHKIVek 149 thale cress
NP_568775 129 AAFVLVAGGLGERLGYNGIKVAlpretttgtcFLQHYIESILALQEasnkidsdgserDIPFIIMTSDdtHSRTLDLLel 208 thale cress
EAR82357  159 VALVIMAGGRNLRYDKDLVKSStdiglpssqcIMELIGRKLWTLKEidl------yssKLLEQLFNQKymAEKFQCYFqs 232 Tetrahymena thermo...
Feature 1                    #                          # ##                           #      
1JV1_A    181 hkyfglkkeNVIFFQQGmlpamsfdgki---ileeknkvsmaPDGNGGLYRALAaqnIVEDMEqRGIWSIHVYCVDNILV 257 human
2ICY_A    150 yt---nsnvDIHTFNQSkyprvvadefvpwpskgktdkegwyPPGHGDVFPALMnsgKLDTFLsQGKEYVFVANSDNLGA 226 thale cress
NP_568775 209 nsyfgmkptQVHLLKQEkvaclddndarlaldphnkysiqtkPHGHGDVHSLLYssgLLHKWLeAGLKWVLFFQDTNGLL 288 thale cress
EAR82357  233 in---qknsYPITDMQGklilknd------------tqchlfPCGTGDVVLQLIhnrHLNKLVeKGYRYIHFIGVENLLV 297 Tetrahymena thermo...
Feature 1                                                                                     
1JV1_A    258 KvadPRFIGFCIQKgaDCGAKVVEKtnptepVGVVCrvd----gvYQVVEYSeislataqkr--------ssdgrllfnA 325 human
2ICY_A    227 Iv-dLTILKHLIQNknEYCMEVTPKtladvkGGTLIsye----gkVQLLEIAqvpdehvne----------fksiekfkI 291 thale cress
NP_568775 289 FnaiPASLGVSATKqyHVNSLAVPRkakeaiGGISKlthvdgrsmVINVEYNqldpllrasgfpd--gdvncetgfspfP 366 thale cress
EAR82357  298 KpldPLFIGIASENrkAINQKIVQVdrn-esEFYRIani---ngrASLLEFDsikkllkqkmvnnksqipkdiddapafL 373 Tetrahymena thermo...
Feature 1      #                                                                              
1JV1_A    326 GNIANHFFTvpFLRDVVNvyepqlqhhvaqkkipyvdtqgqlikpdkpngikmekfvfDIFQFakKFVVYEVLRed-eFS 404 human
2ICY_A    292 FNTNNLWVNlkAIKKLVEadalkmeiipnpke------------vdgvkvlqletaagAAIRFfdNAIGVNVPRs--rFL 357 thale cress
NP_568775 367 GNINQLILElgPYKDELQktggaikefvnpkykdst----ktafksstrlecmmqdypKTLPPt-ARVGFTVMDiwlaYA 441 thale cress
EAR82357  374 FNTLISINFlvEFSHRVDlkqafeskclqltqetpqen-lvqqqngennilifekqigDIIELtdDINFVMVHEae-eFA 451 Tetrahymena thermo...
Feature 1       # 
1JV1_A    405 PLKN 408 human
2ICY_A    358 PVKA 361 thale cress
NP_568775 442 PVKN 445 thale cress
EAR82357  452 PIIF 455 Tetrahymena thermophila SB210

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