Conserved Protein Domain Family
Rnd1_Rho6
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cd04174: Rnd1_Rho6 
Rnd1/Rho6 GTPases
Rnd1/Rho6 is a member of the novel Rho subfamily Rnd, together with Rnd2/Rho7 and Rnd3/RhoE/Rho8. Rnd1/Rho6 binds GTP but does not hydrolyze it to GDP, indicating that it is constitutively active. In rat, Rnd1/Rho6 is highly expressed in the cerebral cortex and hippocampus during synapse formation, and plays a role in spine formation. Rnd1/Rho6 is also expressed in the liver and in endothelial cells, and is upregulated in uterine myometrial cells during pregnancy. Like Rnd3/RhoE/Rho8, Rnd1/Rho6 is believed to function as an antagonist to RhoA. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation.
Links
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Statistics
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PSSM-Id: 206737
Aligned: 3 rows
Threshold Bit Score: 482.25
Created: 1-Mar-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Rho molecules assume an active conformation when bound to GTP and inactive when GTP is hydrolyzed to GDP
  • Comment:Mg2+ ion plays a key role in bringing together the functional regions of the phosphate-binding, switches I and II
  • Citation:PMID 9545299
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              ######                                      ## #          
BAB17851       1 MKERRAPQPVVARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPL 80  human
AAD40670       1 MKERRNPQPAVVRCKLVLVGDVHCGKTAMLQVLAKDCYPETYVPTVFENYTASLETEEQRVELSLWDTSGSPYYDNVRPL 80  African clawed ...
NP_001037861   1 MKERRNAQPLVVRCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLELDDQRVELSLWDTSGSPYYDNVRPL 80  zebrafish

Feature 1                                                     # #                                
BAB17851      81 CYSDSDAVLLCFDISRPETVDSALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLG 160 human
AAD40670      81 CYSDSDAVLLCFDISRPESLDSAMKKWKSEITDYCPNTRILLIGCKTDLRTDLSTIMELSNQKQAPVSYEQGCAVAKQLG 160 African clawed ...
NP_001037861  81 CYSDSDAVLLCFDISRPDIFDSGLKKWRAEILDFCPSTRILLVGCKTDLRTDVCTLMELSNQKQTPITHEQGSAMAKQLG 160 zebrafish

Feature 1                ##                                                              
BAB17851     161 AEIYLEGSAFTSEKSIHSIFRTASMLCLNKPSPLPQKSPVRSLSKRLLHLPSRSELISSTFKKEKAKSCSIM 232 human
AAD40670     161 AENYLECSAFTSEKSVHSIFRAASSLCVNKASPASRKSPVRSLSKRLLNLPSRSEIISSTFKKEKAKSCCLM 232 African clawed frog
NP_001037861 161 AEAYLECSAFTSEKSIHSVFRTAALACINKLQPLAKPSPTRRLSKRLLHLPSKSELLSSTFKKEKAKSCSVM 232 zebrafish

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