Conserved Protein Domain Family
Arl2l1_Arl13_like

?
cd04161: Arl2l1_Arl13_like 
Arl2-like protein 1 (Arl2l1) and Arl13
Arl2l1 (Arl2-like protein 1) and Arl13 form a subfamily of the Arf family of small GTPases. Arl2l1 was identified in human cells during a search for the gene(s) responsible for Bardet-Biedl syndrome (BBS). Like Arl6, the identified BBS gene, Arl2l1 is proposed to have cilia-specific functions. Arl13 is found on the X chromosome, but its expression has not been confirmed; it may be a pseudogene.
Statistics
?
PSSM-Id: 133361
View PSSM: cd04161
Aligned: 10 rows
Threshold Bit Score: 249.232
Threshold Setting Gi: 68129729
Created: 26-Sep-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on alignment to Arl2

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1               #######               ##                     #                           
AAH82574      23 TLVMVGLDNAGKTATAKGIQGe-HPEDVAPTVGFSKIDLRQGKFQVTIFDLGGGKRIRGIWKNYYAESYGVIFVVDSSDE 101 house mouse
NP_878899     23 TLLMVGLDNAGKTATAKGIQGe-YPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDE 101 human
CAI42661      23 TIPIIGLNNSGKTVLVEAFQKl-LPSKTDHCMKSELTTLLLDEYELSIYDLNGDLKGREAWPNYYAQAHGLVFVLDSSDI 101 human
NP_775379     23 TLVMVGLDNAGKTATVRGIQGe-SPLDVAPTVGFSKVDLKQGKFEVTIFDLGGGKRIRGIWKNYYSESYGVVFVVDSSDV 101 zebrafish
AAH59702      23 TVLVVGLDKAGKTSCVRGMLRv-PPGDVGPTHGCVRTELRLENYLVNILDIGGGLEVRGSWREHYGEAHGIIFVVDSSDR 101 zebrafish
NP_001019537  23 TIIVIGLDNSGKSHLVAAFQRl-IPSKMHSEMRPTQTTLLLDDYQVSVYDLTGDLKGREKWPNYYAEAHGLVFVVDSSDI 101 Norway rat
CAG09839      23 TILVVGLDKAGKTCAIRGMSKasYTGETRPTQECIRNELRVDNYLVTLLDVGGSAELRGTWREHYGEAHGIIFVLDSSDK 102 Tetraodon nigro...
CAJ09035     100 TLATFGLDRAGKTCALSVLESgeADKKYTPTVGFAPIKFPLDDYNLCVFDLGGAANFRGIWVHYYHDCFGIVYVIDSAAS 179 Leishmania major
XP_813045     78 TLGTFGLDNAGKTTLISALGGq-IEVNTTPTVGFTPTKFQTEKYDICIFDLGGAANFRGIWVHYFHDCHGLMFVIDSAAD 156 Trypanosoma cruzi
XP_822768     77 TIGTFGIENAGKTTIISALGGn-IEKNPMPTVGFTPTRFQTDRCDLCIFDLGGGANFRGIWVHYFHDCHGFMFVIDSAAD 155 Trypanosoma brucei
Feature 1                                     ## #                                 ###           
AAH82574     102 e-RMEETKETMSEVLRHPRISGKPILVLANKQDKEgalgeaDVIECLSLeklv-nehkCLCQIEPCSAVlgygkkidKSI 179 house mouse
NP_878899    102 e-RMEETKEAMSEMLRHPRISGKPILVLANKQDKEgalgeaDVIECLSLeklv-nehkCLCQIEPCSAIsgygkkidKSI 179 human
CAI42661     102 r-RMQEVKIILTHLLSDKRVAGKPILILANKQDKKkalmpcDIIDYLLLkklv-kenkCPCRVEPCSAIrnlerrnhQPI 179 human
NP_775379    102 q-RIQETRDTMAEVLRHPRIAGKPVLVLANKQDQDgamaeaDIIETLSLeklv-nenkCLCQIEPCSAVlgygkkvdKSI 179 zebrafish
AAH59702     102 q-RMKEVKETLVDLLKHPRVAGKPLLVLANKQDKMnallgnELIEILSLerlv-nqsrSLCHIEPCSASmdlrrwsdRKT 179 zebrafish
NP_001019537 102 a-RIQEVKIILTRLMFDKRVSGKPILILANKQDKKdallpcDIIEYLLLerlv-netkSMCRVEPCSTIrnlpkrhqQPI 179 Norway rat
CAG09839     103 q-RIMEVKEILVDLLKEPRVSGKPLLVLANKQDKMnallgnELIEILSLeklv-nesrSLCHIEPCSALmdlrrwpdRRT 180 Tetraodon nigro...
CAJ09035     180 deRVAESLKVLHETLQHPYVKGKPLLVLANKKDLPesr-gvGVVPQGFLeeamgepgaPHRVLATCAIEd------dPVL 252 Leishmania major
XP_813045    157 daVVRESLNVLRDLSQHRYIKGKPILVLANKKDLEnar-gtKVIPNGFLdklf-grntAYRVVASCGIEe------dPAL 228 Trypanosoma cruzi
XP_822768    156 daVVEESLNALRTVAQHKHVRGKPVLVLANKKDLKssrgveIVSEGLLEelf---gdvSLYHLVPSCGIee-----dPEL 227 Trypanosoma brucei
Feature 1                  
AAH82574     180 KKGLYWLLHI 189 house mouse
NP_878899    180 KKGLYWLLHV 189 human
CAI42661     180 VEGLRWLLAV 189 human
NP_775379    180 KNGLNWLLNN 189 zebrafish
AAH59702     180 LRGLRWLLRA 189 zebrafish
NP_001019537 180 VIGLRWLLAA 189 Norway rat
CAG09839     181 QRGLRWLLRA 190 Tetraodon nigroviridis
CAJ09035     253 VEGIEWLLEA 262 Leishmania major
XP_813045    229 EEGVEWLLSV 238 Trypanosoma cruzi
XP_822768    228 EKGVDWLLTK 237 Trypanosoma brucei

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap