Conserved Protein Domain Family
Rhes_like

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cd04143: Rhes_like 
Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
This subfamily includes Rhes (Ras homolog enriched in striatum) and Dexras1/AGS1 (activator of G-protein signaling 1). These proteins are homologous, but exhibit significant differences in tissue distribution and subcellular localization. Rhes is found primarily in the striatum of the brain, but is also expressed in other areas of the brain, such as the cerebral cortex, hippocampus, inferior colliculus, and cerebellum. Rhes expression is controlled by thyroid hormones. In rat PC12 cells, Rhes is farnesylated and localizes to the plasma membrane. Rhes binds and activates PI3K, and plays a role in coupling serpentine membrane receptors with heterotrimeric G-protein signaling. Rhes has recently been shown to be reduced under conditions of dopamine supersensitivity and may play a role in determining dopamine receptor sensitivity. Dexras1/AGS1 is a dexamethasone-induced Ras protein that is expressed primarily in the brain, with low expression levels in other tissues. Dexras1 localizes primarily to the cytoplasm, and is a critical regulator of the circadian master clock to photic and nonphotic input. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins.
Statistics
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PSSM-Id: 133343
View PSSM: cd04143
Aligned: 8 rows
Threshold Bit Score: 391.034
Threshold Setting Gi: 66911058
Created: 2-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on sequence similarity to Ras, bound to Mg2+/GTP analog

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #######                                        #  #                     
Q96D21     20 YRMVVLGASRVGKSSIVSRFlNGRFEd--qYTPTIEDFHRKVYNIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILV 97  human
NP_956826  20 YRMVILGSTKVGKTAIVSRFlNGRFEe--qYTPTIEDFHRKLYSIKGDVYQLDILDTSGNHPFPAMRRLSILTGDVFILV 97  zebrafish
AAH81268   18 YRMVILGSSKVGKTSIVSRFlSGRFDe--qYTPTIEDFHRKFYSIRGDVYQLDILDTSGNHPFPAMRRLSILTGDVFILV 95  African clawed frog
AAF50620  167 YRLVMLGSSRAGKSSIVARFlGNRFEe--aYTPTIEEFHRKLYRIRNEVFQLDILDTSGYHPFPAMRRLSFLTGDLFILV 244 fruit fly
AAH97177   95 RRVVVLGAPRVGKTALIRRF-LGEEVfeehYEPTSEDFHSKLYHIRGERYQLDILDASKERDFPAKRRLTILTGDIFLLV 173 zebrafish
CAG01105   49 HRVVVLGAPKVGKTNILRRFlGGEFEe--gYEPTTEDFHRKVFYIKGQAYQIDLLEASGERNFPAKRRLSILTGDIFLLV 126 Tetraodon nigrovir...
Q9Y272     25 YRMVILGSSKVGKTAIVSRFlTGRFEd--aYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILV 102 human
AAH74172   20 YRMVVLGASKVGKSAIVARFlNGRFEd--qYTPTIEDFHRKLYNIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILV 97  African clawed frog
Feature 1                                                    ## #                             
Q96D21     98 FSLDNRESFDEVKRLQKQILEVKscl-----knKTKEAAELPMVICGNKNDHGelcRQVPTTEAELLVSGDe-nCAYFEV 171 human
NP_956826  98 FSLDNRESFHEVQRLKQQIYETKscl-----knKTKENVDVPLVICGNKGDREf-yREVQRDEIEQLIAGDe-qCAYFEI 170 zebrafish
AAH81268   96 FSLDNRDSFEEVQKLKQQIMETKscl-----knKTKENVDVPIVICGNKVDRDf-yREVQAHEIDQLVGEDs-kCSYFEV 168 African clawed frog
AAF50620  245 FSMDSRESFEEVVRLRENILETKwaalnpgsgfKKKSLPKIPMILAGNKCDRDf--KTVQVDEVMGYIAGQdncCTFVEC 322 fruit fly
AAH97177  174 FSVTDRDSLTEVCSLREEIFTAKsk------ltKSKENRQLPIIICANKADVDs-pRAVQRSDVAQCLGED---SVLFEV 243 zebrafish
CAG01105  127 FSLDDGESFSEICELLSEIRAAKak------lrKLKTPAKIAAVVCGNKADLKa-pRGPRRPQVTEILGED---AAYFET 196 Tetraodon nigrovir...
Q9Y272    103 FSLDNRDSFEEVQRLRQQILDTKscl-----knKTKENVDVPLVICGNKGDRDf-yREVDQREIEQLVGDDpqrCAYFEI 176 human
AAH74172   98 FSIDNRDSFDEVKRLRKQILEVKscv-----knKTKETGEFPMMICGNKSDYGehhRKVRAEEAERLVSGDe-nCAYFEI 171 African clawed frog
Feature 1     ##                                                                              
Q96D21    172 SAKKNTNVDEMFYVLFSMAKLPHEMSPALHRKISVQYGDafhprpfc-----------mrrvkemDAYGMVSPFARRPSV 240 human
NP_956826 171 SAKRNTNVDQMFQRLFTLAKLPNEMSPDLHRKVSVQYCDilhkkslk-----------nkkvkdgDAYGIVAPFARRPSV 239 zebrafish
AAH81268  169 SAKKNSSLDEMFKALFTMAKLPSEMSPDMHRKVSVQYCEilhkkslk----------skkvkedgDAYGIVAPFARRPSI 238 African clawed frog
AAF50620  323 SARQNYRIDDLFHSLFTVSNLPLEMTPNHHRRLVSVFGApsplpphgsavggtkknalsikrrfsDACGVVTPNARRPSI 402 fruit fly
AAH97177  244 SAKTCTNLEEVFEALAVLGGLPTETRPSLHRDISIHTYHalssrkr-------------nkravnEPCGAVHPLARRPSF 310 zebrafish
CAG01105  197 SAKDGSGLDAAFRTLASLGGLPDETAPSRHQLISIVSYQslcgsqrgr---------gtrarglgAPCAAVDPVARRPSF 267 Tetraodon nigrovir...
Q9Y272    177 SAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDvlhkkalrnkkll-ragsgggggdpgDAFGIVAPFARRPSV 255 human
AAH74172  172 SAKKNVNVDKMFQVLFSMAKLPNEMSPALHRKISMQIGDtfhqksfr-----------lrrlkevDAYGMVSPSARRPSV 240 African clawed frog
Feature 1                                     
Q96D21    241 NSDLKYIKAKvlre------gqarERDKCTIQ 266 human
NP_956826 240 HSDLMYIKEKaigg------gqtkDKERCIIS 265 zebrafish
AAH81268  239 HSDLMYIRAKaigg------gqskDKERCVIS 264 African clawed frog
AAF50620  403 RTDLNLMRSKtmalnegegvrspsRWNRCALM 434 fruit fly
AAH97177  311 SSDLRRVLGPstpk-------kstPIERCQIQ 335 zebrafish
CAG01105  268 TSDLRMVLSSstk---------hnKPERCQIQ 290 Tetraodon nigroviridis
Q9Y272    256 HSDLMYIREKasag------sqakDKERCVIS 281 human
AAH74172  241 NSDLKYIKSKvlge------gqgrDREKCSIQ 266 African clawed frog

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