Conserved Protein Domain Family
RRP22

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cd04142: RRP22 
Ras-related protein on chromosome 22 (RRP22) family
RRP22 (Ras-related protein on chromosome 22) subfamily consists of proteins that inhibit cell growth and promote caspase-independent cell death. Unlike most Ras proteins, RRP22 is down-regulated in many human tumor cells due to promoter methylation. RRP22 localizes to the nucleolus in a GTP-dependent manner, suggesting a novel function in modulating transport of nucleolar components. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Like most Ras family proteins, RRP22 is farnesylated.
Statistics
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PSSM-Id: 133342
View PSSM: cd04142
Aligned: 3 rows
Threshold Bit Score: 360.722
Threshold Setting Gi: 3024572
Created: 2-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on sequence similarity to other members of the Ras family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #######                                       #  #                      
AAH76894    5 VQVAVLGAPGVGKTSIVRRFVAQEFPEEYIPTEHRELHRASAVLSGRLYELHILDVPNmqryp-gtagQEWMDPRFRGLR 83  western clawed frog
AAH41133    5 YRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDFPPisafp-vntlQEWADTCCRGLR 83  human
Q92737      5 LRVAVLGAPGVGKTAIIRQFLFGDYPERHRPTDGPRLYRPAVLLDGAVYDLSIRDGDVagpgsspggpEEWPDAKDWSLQ 84  human
Feature 1                                                 ## #                           ##   
AAH76894   84 NSRAFILVFDICSPESFHHVKLLRQQILDst---nkSPLIVVVGNKRDQQKHRFAPRHVLSVLVKKSWKCGYLECSARSN 160 western clawed frog
AAH41133   84 SVHAYILVYDICCFDSFEYVKTIRQQILEtrvigtsETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYN 163 human
Q92737     85 DTDAFVLVYDICSPDSFDYVKALRQRIAEtrpagapEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECSAKYN 164 human
Feature 1                                             
AAH76894  161 WHILLLFKELLISAttrgr-stspsICLQGALHRERCSIM 199 western clawed frog
AAH41133  164 WHILLLFSELLKSVgcarckhvhaaLRFQGALRRNRCAIM 203 human
Q92737    165 WHVLRLFRELLRCAlvrar-pahpaLRLQGALHPARCSLM 203 human

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