Conserved Protein Domain Family
EF2_II_snRNP
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cd04090: EF2_II_snRNP 
Domain II of the spliceosomal 116kD U5 small nuclear ribonucleoprotein (snRNP) component
This subfamily includes domain II of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and its yeast counterpart Snu114p. This domain is homologous to domain II of the eukaryotic translational elongation factor EF-2. U5-116 kD is a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs.
Links
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Statistics
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PSSM-Id: 293907
Aligned: 21 rows
Threshold Bit Score: 115.026
Created: 15-Jun-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAF56769   477 LMVHSSKMYPndDCTFFQVLARIVSGTLHAGQEVRVLGENYTLq--------------------DEEDSRILQVGRLWVF 536  fruit fly
AAW42901   497 TVVHVTKLYHtaDAEHFRAFGRVMSGTVKVGQVVKVLGEGYSLe--------------------DEEDMISAIVDGIMID 556  Cryptococcus neo...
XP_639111  516 LLIYITKLLSkpDGKGFDCLGRIMSGSISKGQSIRVLREKYSPd-------------------nNEEDMEECECEGVFIG 576  Dictyostelium di...
EAN31518   532 LVIFITKNYYnsGDAGFNLFGRIFSGTIRKGQKVKLLGPAYTLd--------------------DDEDMVVRDVGSVWIS 591  Theileria parva
CAE76428   487 LVLYVSKLFSapDAKSFYSFGRVMSGIARPGTEVRVLGEGYSId--------------------DEEDMAMGRISDVFIA 546  Neurospora crassa
XP_500302  464 TVVKVAKLIAsaDRESFYALSRIVSGSVRLGQKVKVLGAHYVPn-------------------eDEEDCADATITDLFVS 524  Yarrowia lipolyt...
XP_710582  509 TLARVTKLIEssDGKSFSALVRIYKGGLTMGDKIKIYGENYHE---------------------DKDDYKLEIIKKIYLP 567  Candida albicans...
CAH02886   434 TVVHVLRHMS--LEGSKWSLCRIIEGSVKKGNKLYIFNESVDSvv-----------------dfGDDEYSKVTIERVALM 494  Kluyveromyces la...
AAS52561   444 TVAHVLKLME--YGGELWSLVRIYSGELRAKDFVSVINESQDVsa------------------iEEDEITKVQVGQVALL 503  Ashbya gossypii ...
P36048     468 LWAHVLKTVD--YGGAEWSLVRIYSGLLKRGDTVRILDTSQSEsrqkrqlhdisktetsnededEDDETPSCEVEEIGLL 545  baker's yeast

AAF56769   537 ESRYKVELNRVPAGNWVLIEGIDqCIVKTSTIVD 570  fruit fly
AAW42901   557 ESRYNVDIERAPAGNLVLLSGVDaSISKTATIVS 590  Cryptococcus neoformans var. neoformans JEC21
XP_639111  577 EARYKIEIEKAQAGMWVLLDGVDgPIVKTATITS 610  Dictyostelium discoideum AX4
EAN31518   592 EARYRVEVTSMCAGNWVMLSGIDiSHYKTTTVTE 625  Theileria parva
CAE76428   547 ETRYNIPTDGVPAGNWVLLGGVDnSIVKTATIVE 580  Neurospora crassa
XP_500302  525 QTRYKYTVVSAPVGNIVLIGGIDkTIIKNATVTT 558  Yarrowia lipolytica CLIB122
XP_710582  568 GGRYNFPINQASLGNIVLIDGIDsIIKKGSAIIT 601  Candida albicans SC5314
CAH02886   495 GGRYVYELEEAIKGQIVLLKGFEdQYTKYATLSS 528  Kluyveromyces lactis NRRL Y-1140
AAS52561   504 GGRYILPVTHASAGQLVLVKGLDeYYTKSATIFT 537  Ashbya gossypii ATCC 10895
P36048     546 GGRYVYPVHEAHKGQIVLIKGISsAYIKSATLYS 579  baker's yeast
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