1IC6,1S2N,2B6N,3BPS


Conserved Protein Domain Family
Peptidases_S8_PCSK9_ProteinaseK_like

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cd04077: Peptidases_S8_PCSK9_ProteinaseK_like 
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Peptidase S8 family domain in ProteinaseK-like proteins
The peptidase S8 or Subtilase clan of proteases have a Asp/His/Ser catalytic triad that is not homologous to trypsin. This CD contains several members of this clan including: PCSK9 (Proprotein convertase subtilisin/kexin type 9), Proteinase_K, Proteinase_T, and other subtilisin-like serine proteases. PCSK9 posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. Characterized Proteinases K are secreted endopeptidases with a high degree of sequence conservation. Proteinases K are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity. The number of calcium-binding motifs found in these differ. Proteinase T is a novel proteinase from the fungus Tritirachium album Limber. The amino acid sequence of proteinase T as deduced from the nucleotide sequence is about 56% identical to that of proteinase K.
Statistics
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PSSM-Id: 173790
View PSSM: cd04077
Aligned: 116 rows
Threshold Bit Score: 216.613
Threshold Setting Gi: 19173076
Created: 4-Oct-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                 #                                      
1IC6_A         8 WGLARISStspgtst----------yyydesaGQGSCVYVIDTGIEASHp-eFEGRAQMVKTyyyss----------rdg 66  Engyodontium album
1S2N_A         6 WGLDRIDQrnlpldr----------nynanfdGFGVTAYVIDTGVNNNHe-eFGGRSVSGYDfvdnda-------dssdc 67  Vibrio sp. PA-44
3BPS_A         4 WNLERITPpryrade-----------yqppdgGSLVEVYLLDTSIQSDHr-eIEGRVMVTDFenvpeedgtrfhrqaskc 71  human
NP_597627    221 NWIFRVLQikrvmtkfl-------gsyeyyhtGKGVNIFLLDTAISSMDgacNLSGRLEACN------------------ 275 Encephalitozoon...
CAG10926      85 WSLRRLPRprgr-----------------pgdGAAVEVYLMDGSVLSSHr-eLGGRVLVTDFhsvpvgeag-ghreasrc 145 spotted green p...
AAH85208     147 WNLDRIVPaqqmasq-----------fsppntGDSVEVYLLDTSIQSNHr-eIEGKVFVTDFqnvpeedgtrfhrqaskc 214 African clawed ...
XP_001646959 104 EHLARLSNgvsnsrvsakn---enafifhshaGIGVDVYIVDSGIDSQHp-aFMNRHISKLIdltdnpi------pvgdp 173 Vanderwaltozyma...
XP_001839613  91 HALASVTHalnfry------------tydssgGAGVDIYVLDTGVRLTHv-eFEGRARSGAVfggya---------ptdg 148 Coprinopsis cin...
XP_001882545  94 WGVSRINHvkslkgksdqltnydyeydstsevGSGVDIYILDSGICTEHv-dFGGRATWGITingtd---------gvdv 163 Laccaria bicolo...
CAQ43377     100 VGLSSISPlshqpf------------iyrsngGNGVDVYLLDTGIDIKHp-nLSKLNILRMAdltqspv-----pqgtdp 161 Zygosaccharomyc...
Feature 1          #                                                                             
1IC6_A        67 nGHGTHCAGTVGSRTYGvak---------ktQLFGVKvlddn---------gsgqySTIIAGMDFVASdknnrncpkGVV 128 Engyodontium album
1S2N_A        68 nGHGTHVAGTIGGSQYGvak---------nvNIVGVRvlscs---------gsgttSGVISGVDWVAQna-----sgPSV 124 Vibrio sp. PA-44
3BPS_A        72 dSHGTHLAGVVSGRDAGvak---------gaSMRSLRvlncq---------gkgtvSGTLIGLEFIRKsqlv-qpvgPLV 132 human
NP_597627    276 -AHGNVMAELLVGKTNGfakd-------srlSVLDVVdcdg-----------kvalSEMIHGLEGLREsg------gPSI 330 Encephalitozoon...
CAG10926     146 kGHGTHVAAVVMGSDTGvapg-------arvNLVRVLdcrg-----------kgtvSGALAGVEYIRAalra-hppgAAV 206 spotted green p...
AAH85208     215 eSHGTHMAGVVNGRDAGvak---------gvNVRSLRvlncq---------gkgtvSGSLTGLEFIRKtlie-qpynPLI 275 African clawed ...
XP_001646959 174 hGHGTAIAGLVTSDTFGvmk---------kaNLFDVRvvdaes--------ngvklSKLLKSLEFIENhsra--tmrPSV 234 Vanderwaltozyma...
XP_001839613 149 qGHGTHCAGTAAGRNKA--------------NIVSVRvlsds---------gsgsvSNVVSGINWIYTaatt--sgrPAV 203 Coprinopsis cin...
XP_001882545 164 kGHGTHVASVNFITRSSilltkcyqsgiaggSRWGIAkganliavkvlddeghgrqSYNLIGLEYVFMrrlf--dgrSSI 241 Laccaria bicolo...
CAQ43377     162 qGHGTAMAGIIASETFGvlk---------kcNLVDVRvadsn---------gdvklSTILQALTLTQRhieg--tkrPSV 221 Zygosaccharomyc...
Feature 1            ##                            #                                             
1IC6_A       129 ASLSLGggy--ssSVNSAAARLQSsgVMVAVAAGNNnadar----nyspASEPSVCTVGASDrydr-------------- 188 Engyodontium album
1S2N_A       125 ANMSLGggq--stALDSAVQGAIQsgVSFMLAAGNSnadac----ntspARVPSGVTVGSTTssds-------------- 184 Vibrio sp. PA-44
3BPS_A       133 VLLPLAggy--srVLNAACQRLARagVVLVTAAGNFrddac----lyspASAPEVITVGATNaqdqpv------------ 194 human
NP_597627    331 LVFGVSgpy--saSLNSAVDRISSrgTVVVSPAGNShdqsc----nyspGSSKSVINVGSVDkhag-------------- 390 Encephalitozoon...
CAG10926     207 VLLPFTgaf--srSLNAACRDLVNtgAVVVAAAGNYrddac----lyspASEPEVCTGGSARshthththththllqavl 280 spotted green p...
AAH85208     276 VIIPFVggy--srILNAASRALVNtgVIIIAAAGNYkddac----lyspASEPEVITIGATNyqdqpa------------ 337 African clawed ...
XP_001646959 235 AVLPFSmsk--naILNSAIESMPNs-IAIVVPAGNQhhmacn-fspasaRNSQSILSVGSLDyrssi------------- 297 Vanderwaltozyma...
XP_001839613 204 VLIALGgga--ssAVDNAVTALTNagIHVVAAAGGSntgte----ntspARVPSVITVGATAitda-------------- 263 Coprinopsis cin...
XP_001882545 242 INMSYGgqqgqseIIDFALMRITSvgIHVTVAAGNKnvdak----dtspANCPCVNTVGATDinddryikehdddtitgs 317 Laccaria bicolo...
CAQ43377     222 VVIPLEvedgnnpILTEAIASFDQs-VPIIIPAGNNaqdalnfspanvnPKPKNIIVVGSVDvnnn-------------- 286 Zygosaccharomyc...
Feature 1                                                                      #  #              
1IC6_A       189 ---------------------rssFSNYGSVLDIFGPGtdILSTwi---------ggSTRSISGTSMATPHVAGLAAYLM 238 Engyodontium album
1S2N_A       185 ---------------------rssFSNWGSCVDLFAPGsqIKSAwy---------dgGYKTISGTSMATPHVAGVAALYL 234 Vibrio sp. PA-44
3BPS_A       195 -------------------tlgtlGTNFGRCVDLFAPGedIIGAssd-------cstCFVSQSGTSQAAAHVAGIAAMML 248 human
NP_597627    391 ---------------------isrFSNHGDCIRMFAPG--EDVL-------------QDSSLTGTSLSAAIVASSIALFL 434 Encephalitozoon...
CAG10926     281 cvcvqvitvgavnsadqlvsqgpgGTNVGRCVDVFAPGgdIVSAssd-------cdtCFASGSGTSQAAAHAAGMAAVLL 353 spotted green p...
AAH85208     338 -------------------tmgvlGTNYGNCIDLFAPGddIIGAssd-------cstCFTSKSGTSQAAAHVAGIAAMIL 391 African clawed ...
XP_001646959 298 --------------------eiasFSNYGECVDVFTSGvqMDTLhattn----sdenYISKVSGTSMSCAIAAGTVGYYM 353 Vanderwaltozyma...
XP_001839613 264 ---------------------rssFSNYGPGIDIFAPGqsVYSA-------------WHTSDTAAAHVAGAIAYLIGLEG 309 Coprinopsis cin...
XP_001882545 318 ------nfgellcglgvelqltgyLLYAGPCVDFFAPGfqITSCsikkdk--ngkytKSTKKDGTSMAAPLVAGVIAAII 389 Laccaria bicolo...
CAQ43377     287 ---------------------ptkFTNYGSNVDVFTVGeqITTLqstdldsqglsnsLTRQVSGTSASSAITAGVIGYYM 345 Zygosaccharomyc...
Feature 1                                         
1IC6_A       239 TLGktt-------------aaSACRYIADTANK 258 Engyodontium album
1S2N_A       235 QENngl------------tplQLTGLLNSRASE 255 Vibrio sp. PA-44
3BPS_A       249 SAEpel------------tlaELRQRLIHFSAK 269 human
NP_597627    435 ETSpra------------afpQIWGYLNQNSFW 455 Encephalitozoon cuniculi GB-M1
CAG10926     354 SSSpsl------------tpvQVLQTLLRYSVS 374 spotted green pufferfish
AAH85208     392 NDKpdl------------svsELRQRLIQFSTK 412 African clawed frog
XP_001646959 354 SLGls--------------svEAIEKIKSAKEI 372 Vanderwaltozyma polyspora DSM 70294
XP_001839613 310 NVSp----------------aAMEAKLKARANQ 326 Coprinopsis cinerea okayama7#130
XP_001882545 390 SLVgdipppgmtnilkalclrNILGRIPDDGTP 422 Laccaria bicolor S238N-H82
CAQ43377     346 SLGlnst----------qsinKVLQYSRCANTF 368 Zygosaccharomyces rouxii

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