1R64,2OXA,1P8J


Conserved Protein Domain Family
Peptidases_S8_Protein_convertases_Kexins_Furin-like

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cd04059: Peptidases_S8_Protein_convertases_Kexins_Furin-like 
Click on image for an interactive view with Cn3D
Peptidase S8 family domain in Protein convertases
Protein convertases, whose members include furins and kexins, are members of the peptidase S8 or Subtilase clan of proteases. They have an Asp/His/Ser catalytic triad that is not homologous to trypsin. Kexins are involved in the activation of peptide hormones, growth factors, and viral proteins. Furin cleaves cell surface vasoactive peptides and proteins involved in cardiovascular tissue remodeling in the TGN, at cell surface, or in endosomes but rarely in the ER. Furin also plays a key role in blood pressure regulation though the activation of transforming growth factor (TGF)-beta. High specificity is seen for cleavage after dibasic (Lys-Arg or Arg-Arg) or multiple basic residues in protein convertases. There is also strong sequence conservation.
Statistics
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PSSM-Id: 173789
View PSSM: cd04059
Aligned: 75 rows
Threshold Bit Score: 223.976
Threshold Setting Gi: 124021781
Created: 4-Oct-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
1R64_A         13 INDPLFERQWHLvnps------------------------------------------fpgsDINVLDLWYnn---iTGA 47   baker's yeast
YP_001840622   57 GTDSLYDDQWHLqnygql--------------------------------------ggttgeDARVKPVWDqg---ySGN 95   Leptospira bi...
NP_967370      35 GADPLLGYAWHInntgqkvfa---------------------------------tdagtagvDLNLLQSWTgg---lTGS 78   Bdellovibrio ...
ZP_01132299    33 GGDPLTPQQWHLqntgqsgfs---------------------------------lsngiagnDLDLDFAHLmg---iKGR 76   Pseudoalterom...
NP_902387      24 PGDPLANQQWHLkntgqtafs---------------------------------krggvkgvDLNLAFTHLrg---iRGL 67   Chromobacteri...
2OXA_A         27 GANPLQDQQWYLlnsgqdg------------------------------------fsarggiAGNDLNLWWahrtgvLGH 70   Aeromonas sobria
ZP_02197724    61 GNDPFKAQQWHLmntgqdg------------------------------------falrggvAGNDLNLWWahrrgiYGE 104  Vibrio campbe...
YP_869317     123 HGDPLFTYQWHLkntgqnafa---------------------------------ahrgvageDMNVSGAISdn---aMGQ 166  Shewanella sp...
ZP_01135833   132 EKDPLANEQWHLrntgqrafarsdefltvmaklnglttddeiaqykqtrldhfnqnltlvgaDMNVAQAYQqg---vTGK 208  Pseudoalterom...
YP_001016088  159 TPDPLFHLLASNdan--------------------------------------------gsyGVNAVGAWSq----vSGE 190  Prochlorococc...
Feature 1                ##                                                                  #  # 
1R64_A         48 GVVAAIVDDGLDYENEDLKDNFca------------------------eGSWDFNDNTNLPKPRl---------SDDYHG 94   baker's yeast
YP_001840622   96 QVIVSVVDDGLDIRHEDLAANIsi-----------------------stRGLNLFNNTFNPSHSy---------TNSFHG 143  Leptospira bi...
NP_967370      79 GIKIVISDDGVQDAHPDLKDNFly------------------------gVSKNYHTSGTNNAPPn--------sADDNHG 126  Bdellovibrio ...
ZP_01132299    77 GITVAVIDSGVEISHPDLKANV---------------------------VAGSLNVADGSDFPT----------DLNGHG 119  Pseudoalterom...
NP_902387      68 GTTIAVIDDGLEIKHPDLAANIv-------------------------pGSKNLVDGSNDPSPS----------GDNGHG 112  Chromobacteri...
2OXA_A         71 GVNVAVVDDGLAIAHPDLADNVr-------------------------pGSKNVVTGSDDPTPTd---------PDTGHG 116  Aeromonas sobria
ZP_02197724   105 GVNVAVVDDGLEIGHPDLAANItp------------------------nASYDFVGQDRDPTPTs---------PGDAHG 151  Vibrio campbe...
YP_869317     167 GITVAVVDDGLEIAHPDLMNNTvn------------------------gGSYNLITGTVDPTPFs---------GESGHG 213  Shewanella sp...
ZP_01135833   209 GVIAVVVDSGLEVRHEDLDDNVlpyr--------------------slnLNPGAFDQTDPTKPVpadgvyksfgDFSDHG 268  Pseudoalterom...
YP_001016088  191 GITVGVLDTFFDLNHTDLNAAMptnfdwdndgqndgvdnnnnnipdlfeSEQFTHALGSPNWPVnnpp--qptpPNQSHG 268  Prochlorococc...
Feature 1                                                     #                             #     
1R64_A         95 TRCAGEIAAKKGNnfcGVGVGYNAKISGIRILsgd----itTEDEAASLIYGLDVN------------DIYSCSWGPADD 158  baker's yeast
YP_001840622  144 SAVGGVIGATGGNgmgVRGAAPCSKLVGVNILek-----stIFTSDEYRAMVNESGr----------vFISNNSWGSPDL 208  Leptospira bi...
NP_967370     127 TAVAGLAAAVGDNgvgSKGVAYKAKLLAYNFLs-------tGVSQTFSRMAEQLSGg----------yDVYNMSWGNSQN 189  Bdellovibrio ...
ZP_01132299   120 TSVAGLIAAVEGNgigGRGVAPLASLVGFNFLan-----qtVASWLVSHGLSEDFRaldr----ftdpRVFNQSYGSTPA 190  Pseudoalterom...
NP_902387     113 TAVAGIAAAVAFNgigGRGIAPSAGLKGFNWL---------LNQTLDGWLLAHGKKpnggpleaftdaRVFNQSYGSSTI 183  Chromobacteri...
2OXA_A        117 TSVSGIIAAVDNAi-gTKGIAPRAQLQGFNLLddns--qqlQKDWLYALGDSNASRd----------nRVFNHSYRMSVV 183  Aeromonas sobria
ZP_02197724   152 TSVAGIIAAVRDNnigGQGVAPEAALRGFNFLgrd---aqtLTNWYISHGQPGRSDd----------vRIFNQSYGIGGI 218  Vibrio campbe...
YP_869317     214 TAVGGIIAAEGWNgigGRGVAPKAKLIGFNFLdqdptgkveNVQTFENFAKSHGASays------dsaRVFNQSYGYSVP 287  Shewanella sp...
ZP_01135833   269 TAVAGLIAAEGWNgkgGRGVAPDAQLIGMNFIhsk----tkQNDFNVQAIINGFPGsgia----ldeeVLFNRSYGSNPA 340  Pseudoalterom...
YP_001016088  269 TAVSGIAVGRSNGn-sGIGVAPESNWIPDGFL---------DHQNLWPSQNYYNYA------------DVVNNSWGMPNT 326  Prochlorococc...
Feature 1                  #                               #                                     #
1R64_A        159 Grh-----lQGPSDLVKKALVKGVTEGrd-skGAIYVFASGNGgt---------------------------rgDNCNYD 205  baker's yeast
YP_001840622  209 Ygw-----lWPSSSLWQQGINEGVSLGrg-gkGTVYFWAAGNGanggtv-------------------asptlvDNANFD 263  Leptospira bi...
NP_967370     190 Yl-------PDPVAAWETALLNGVLNGrs-gkGSIYVKSAGNDflveckg-----------------stdtyciGNSNLD 244  Bdellovibrio ...
ZP_01132299   191 TpraydyvtNPFLELTDQVQADISLNShw-grGAVYVKSAGNSfgsyttayrgqliqvlpyeggqfynnnglpfHSANIS 269  Pseudoalterom...
NP_902387     184 TsvpanpdqDIELKTEEETYEDISRNShw-grGAVFVKSAGNAynsfrlnqtesl--------lgyqgnnglpiQDSNLT 254  Chromobacteri...
2OXA_A        184 Dp-------RSANSLDQSQLDRLFEQQtlkaqGAAYIKAAGNGfnkiaaggyvl---------nrtgngpklpfENSNLD 247  Aeromonas sobria
ZP_02197724   219 As------gDYSDNFMERTYRHMSMNSnn-glGAAFIKSAGNGyniiglggrdyi--------aptgnnsglpwQNSNQA 283  Vibrio campbe...
YP_869317     288 Fp-------HGFDEDETEVYQDIATQSfd-gkGSIFVKSAGNGynyyryrtfwlpgdy-ftataekpanhglpfHNSNMS 358  Shewanella sp...
ZP_01135833   341 Lf-------LPDDQIDNYLTSYATTILrn-gkGAISVKASGNDfesgrhsdgdfc-------kksgtnelglgcIDMNVS 405  Pseudoalterom...
YP_001016088  327 A--------GVFQTWTPQRLANWQLATd----GAIQVVTAGNDrdpgn---------------------tanqgWSNTNN 373  Prochlorococc...
Feature 1                                                                                         
1R64_A        206 GYTNSIYSITIGAIDhkDLHPPYSEGCSAVMAVTYSSgsg----------------------eyIHSSDIn--------- 254  baker's yeast
YP_001840622  264 GQANYYGVMAIGGIGqnGMKASYSESGANLWVVAHTQgnnas-----------------ayttaISTTDAsggfgfnag- 325  Leptospira bi...
NP_967370     245 PDNSTPYTILVTALNstGDAASYSSVGSNVWISSFGGesgdd------------------spamVTTDRTgctagyaqts 306  Bdellovibrio ...
ZP_01132299   270 TDNNNYWNLVVSAINaeGKLSSYSSVGSSVFLSAPGGeygt-------------------dspaMVTIDLtgcdkgmnva 330  Pseudoalterom...
NP_902387     255 SDNNNYWNVVVSALNadGVRSSYSSVGANVLLTAPGGeygt-------------------dspaMVTTDLsgcargynvt 315  Chromobacteri...
2OXA_A        248 PSNSNFWNLVVSALNadGVRSSYSSVGSNIFLSATGGeygtd------------------tpamVTTDLPgcdmgynrtd 309  Aeromonas sobria
ZP_02197724   284 GDNANYWNIVVSALNadGERSSYSTVGSNVFLTALGGeygsrsp--------------ahvttdLTGCDMgynsqfrgvp 349  Vibrio campbe...
YP_869317     359 SDNANVYNLVVSAINakGELSSYSSVGSNIFVTAPGGeygdddpaivt-----tdrmgcengsaIAEDRPstpfhggl-- 431  Shewanella sp...
ZP_01135833   406 AANRSLNHVTVGALKanGKRASYSTSGSGLFLSAPAGesgqwepamittdnmtclngssgfpllNYLEGLygqpagfvag 485  Pseudoalterom...
YP_001016088  374 SEKTRRENIVVAATMrnGEVEQYSTPGASVFVSAPVNgsnfrfans---------ffanagvqrTTTADVtdnvasna-- 442  Prochlorococc...
Feature 1                                   #                                  
1R64_A        255 ----------------gRCSNSHGGTSAAAPLAAGVYTLLLEANpnltWRDVQYLSILSAV 299  baker's yeast
YP_001840622  326 --------gtggdyvfsNYTRRFNGTSSATPLAAGVAALLLSKYpeftWRDVRELIAYSAR 378  Leptospira biflexa serovar Patoc...
NP_967370     307 isgkvefergnngnsncNYTTTFNGTSSAAPVLTGAIALLLEANpnlnWRDVKYILAKTAV 367  Bdellovibrio bacteriovorus HD100
ZP_01132299   331 gdhpnalhggteldpncDYNGTMNGTSSAAPNTSGAIATIMSANhaldARTVRHLLAQTAR 391  Pseudoalteromonas tunicata D2
NP_902387     316 gntanglhggtaldpncDYNGVMNGTSSAAPSTSGSFAVVMSANpalsARDVRHILITTAR 376  Chromobacterium violaceum ATCC 1...
2OXA_A        310 dpstnrlhgnsqldascDYNGVMNGTSSATPSTSGAMALLMSAYpdlsVRDLRDLLARSAT 370  Aeromonas sobria
ZP_02197724   350 hrn-hllhgstkldptcDYNSTMNGTSSAAPNTSGAFALMMSAYpnltQRDIRHLLATTAT 409  Vibrio campbellii AND4
YP_869317     432 ----------nplnpncDYTSTMNGTSSAAPNTSGAVAVIMSANpdlsWRDVRYILAKTAT 482  Shewanella sp. ANA-3
ZP_01135833   486 yhf--fdypghplnascNYTNSMNGTSSAAPNTSGVIALVMEANpaltARDIKHVLATTAT 544  Pseudoalteromonas tunicata D2
YP_001016088  443 ---------dnsgymngPTDTRFNGTSAAAPMVTGAIALMLEANptltVRDIQHILTETSV 494  Prochlorococcus marinus str. MIT...

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