Conserved Protein Domain Family
C2B_Tricalbin-like

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cd04052: C2B_Tricalbin-like 
C2 domain second repeat present in Tricalbin-like proteins
5 to 6 copies of the C2 domain are present in Tricalbin, a yeast homolog of Synaptotagmin, which is involved in membrane trafficking and sorting. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-II topology.
Statistics
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PSSM-Id: 176017
View PSSM: cd04052
Aligned: 44 rows
Threshold Bit Score: 101.14
Threshold Setting Gi: 254571211
Created: 11-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_587862     689 VGDVTAEEGselPSSYVCVDLDDtLVYKTRTKVFTSNPIYNAGSEKFVKDWRNAMLCFTVRDFKlrehDSILGVVNIPLA 768  fission yeast
EDK40612      457 KDLDISRSVvglLNPYAEIYVNNeLTKSCRRLRQTNEPSWNQSFESLITQQSETQVQVLIKDSAd---DDIVAKLDASLQ 533  Pichia guilli...
XP_449265     639 KNLDLSSSIsgtLNPQAELLMDGqLIKTFRKVKRNNEPNWEESVEFLVPSQTDSKLTLKIWDDHks-hREFLCEYSGTAS 717  Candida glabr...
XP_001643952  646 RSLDLSYAVggvISPSAELRLNGrLVKRYRTLKKTNEPSWNETIELFVNSKSSSVLELTVFDERsk-rRAVLCSIKASLA 724  Vanderwaltozy...
NP_985007     618 KYLSTSTSItgsLSPSAELFVDSkKVKSYRTLRHMNEPSWEDPVEILIPSKRTTEFTLKIYDERfs-gKELICEFSAPFE 696  Ashbya gossyp...
XP_451743     634 KYLNKSAALtgfLSPCAELFIDGkKVKSYRTLRRINEPSWEETIEILIPSKSKSELSLKLYDDQmh-gKRQLAEYTASME 712  Kluyveromyces...
Q03640        673 KYLDTTSSMtgsLSPCAELFIDGqKVKSYRTLRRINEPSWNETIEVLVPSKSNSKFVLKIFDDRmn-gKALICEYSSSLD 751  baker's yeast
XP_002495575  756 KYLNTAVALtgtLSPSATLFLNGnVVKEFRTLKRINEPSWGETIELFIPSREESELRLEVYDNGlr-eKKLICEYGSTLE 834  Zygosaccharom...
XP_002553432  662 TNLKHATAVqgaLSPSAELFVDGkSVMHFRTLRRINEPSWEQSIEVLVPSKKNSTLLLKVYDQGia-gREELCKYSTSME 740  Lachancea the...
XP_002619796  529 TNLDISHSVtgvLNPYAEIYINNkFVKRSRNLRETNEPDFGVSFESFITQQSETQIQVLVKDAAe---DLVVGKLDTNLQ 605  Clavispora lu...
NP_587862     769 TTLTTSSQLTKWYPIqg---giGFGSVRISILFRSM 801  fission yeast
EDK40612      534 DLIFETSRGQQWITCqpireggPHSRIKISAGWKPL 569  Pichia guilliermondii ATCC 6260
XP_449265     718 EIMDSLSMGASSLEAs------PQGYINVDLQWKSV 747  Candida glabrata CBS 138
XP_001643952  725 TFFEVISIGQDYINAs------PKGQIYFFAQWKPV 754  Vanderwaltozyma polyspora DSM 70294
NP_985007     697 ELLNIASSDSEYLTGs------PQGEIYFTAVWKPV 726  Ashbya gossypii ATCC 10895
XP_451743     713 DVIELFEQGQTFVQAs------PQGEIYITSSWKPV 742  Kluyveromyces lactis NRRL Y-1140
Q03640        752 DIMTTLDTAQEFVKGs------PQGDIYLDVSWKSI 781  baker's yeast
XP_002495575  835 DIFENLQNGEPFVKGs------PQGEIYMNAEWKPV 864  Zygosaccharomyces rouxii CBS 732
XP_002553432  741 DVLSMADAGQSVLQAs------PQGRIYMSAAWKPV 770  Lachancea thermotolerans CBS 6340
XP_002619796  606 DLIFETSRGQQWLSApsvaeggEPAKFKIGAKWKAI 641  Clavispora lusitaniae ATCC 42720
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