Conserved Protein Domain Family
C2_SRC2_like

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cd04051: C2_SRC2_like 
C2 domain present in Soybean genes Regulated by Cold 2 (SRC2)-like proteins
SRC2 production is a response to pathogen infiltration. The initial response of increased Ca2+ concentrations are coupled to downstream signal transduction pathways via calcium binding proteins. SRC2 contains a single C2 domain which localizes to the plasma membrane and is involved in Ca2+ dependent protein binding. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176016
View PSSM: cd04051
Aligned: 59 rows
Threshold Bit Score: 99.6126
Threshold Setting Gi: 223946461
Created: 4-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAA07573       5 SLDLTIISAEDLKdvql---------igkQDLYAVVSIngd---artKQKTKVDKDCg----TKPKWKHQMKLTVddaaa 68  thale cress
CAN72571       7 VVEITVISGEDLRvnsr--------rpvkKNAFAVVRTds-----knYQMTRVDTEGg----SYSTWNEKLVMNLpah-- 67  wine grape
XP_002302565  10 TIEITILSAENLSldrk---------svkKNAYVIARIdp-----inYGSTKADFEGg----CNPSWNEKLTLDMpfq-- 69  black cottonwood
XP_002511806   7 TLEITIFSCEDLRidrr---------svkNNTYVVVRTdh-----lnSTATKIDTQGg----SYPSWNEKLIVDMplh-- 66  castor bean
AAC28548       9 SLEIEVISAEGLKvdrk---------plkKKTYSVVRIde------kSWASKVDELGg----SYPIWKDRFDMEMpina- 68  thale cress
ACU16116       4 TVEITVLSAENLQmnkk---------pirGNAFVTVQSdas----ndTSATTVDSEGg----SYPSWNEKLVMDVplh-- 64  soybean
CAN82266      10 VIEITIVSAEGLKntstffskrirpfitlTTAPPTPYKptgadkqsqVYMTRVDDEGg----INPTWGDKFRLPMeatff 85  wine grape
NP_567111     19 TLEIDLRSAEGLKlnrr---------pikKKTFAVVKIde------kCRKSNLDESRr----SNPTWNYKSEMPIngn-- 77  thale cress
ACU19695       9 ILEITVMSGENISvdrs---------svaANVYVVVRAes-----lnSCTTKMVNGDg----GVHAWNEKFLLGIpsy-- 68  soybean
BAD46356       7 TLEVTVVSAEEVVlpptr-------rplgRGAYAVVRTaasasspaaAVCTRVDEESggdcnGYPYWKETLRVALpeg-- 77  Japanese rice
CAA07573      69 rdnrlTLVFEIVADRpi-aGDKPVGEVSVPVKELldqn-----------kgdEEKTVTyavrlpnGKAKGSLKF 130 thale cress
CAN72571      68 ---arFLTVEVHCKTs--sGDRVIGTARVPVSDFsggstpes---yxhflsyRLRDDK-------GERNGIVNL 126 wine grape
XP_002302565  70 ---trFITLEVKCKTs--sGDRVVGTASLPISDIsgdytpes---hlhflsyRLRDSR-------GEKNGIINV 128 black cottonwood
XP_002511806  67 ---erFITLEARCKTa--sADRIIASARMPVTDFmggylpdn---ylnilsyRLRDTR-------GERNGIINL 125 castor bean
AAC28548      69 --svrFISIEVYYRTsgsgRDKNVGYAKIPVTDFmggfapqg---hlnflsyRLRDEY-------GDKCGIVNV 130 thale cress
ACU16116      65 ---arFITVEVKCKTss-aGSNSIGVARIPVSDFvggyvpen---qlhflsyRLWDGK-------VRRNGVVNI 124 soybean
CAN82266      86 shrysAIYLHIYTKRlm-kGKIQLGWCQIPAGDIlegfspag---tlrhlsyRLRDRDg------TRGHGIVNV 149 wine grape
NP_567111     78 ---eqFIFIEVFYRTgs-gHDKKIGEAKIPTNDFmgryspeg---hlnflsyRLRDEF-------GDKCGIVNL 137 thale cress
ACU19695      69 ---arSVTFEVQCMNy--kGVRPIGVARIALSDLlsnntkivsesvpqmlcyGLRNWE-------GRRNGVIHF 130 soybean
BAD46356      78 ---arWLDVEICRRRpn-gQVEAVAAASVPVGDFtvgppgh-----lhclsyRLFDASgc----rTRRNGIVNI 138 Japanese rice
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