1WFJ


Conserved Protein Domain Family
C2_putative_Elicitor-responsive_gene

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cd04049: C2_putative_Elicitor-responsive_gene 
Click on image for an interactive view with Cn3D
C2 domain present in the putative elicitor-responsive gene
In plants elicitor-responsive proteins are triggered in response to specific elicitor molecules such as glycolproteins, peptides, carbohydrates and lipids. A host of defensive responses are also triggered resulting in localized cell death. Antimicrobial secondary metabolites, such as phytoalexins, or defense-related proteins, including pathogenesis-related (PR) proteins are also produced. There is a single C2 domain present here. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members have a type-II topology.
Statistics
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PSSM-Id: 176014
View PSSM: cd04049
Aligned: 11 rows
Threshold Bit Score: 183.303
Threshold Setting Gi: 159163299
Created: 30-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Ca2+
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #      #                                                    # # 
1WFJ_A        10 GTLEVVLVSAKGLEDADfl-nnMDPYVQLTCrtqDQKSNVAEgm-gtTPEWNETFIFTVSeg-----ttELKAKIFDKDv 82  thale cress
Q9ZT46         4 GMMEVHLISGKGLQAHDplnkpIDPYAEINFkgqERMSKVAKna-gpDPIWNEKFKFLVEypgs-ggdfHILFKVMDHDa 81  winter squash
BAC41817       4 GILEVSLISGKGLKRSDfl-gkIDPYVEIQYkgqTRKSSVAKedggrNPTWNDKLKWRAEfpgs-gadyKLIVKVMDHDt 81  thale cress
ABK26300       4 GTLEVLLLNAKGLQTTDfl-ckMDPYCIIKCrtqQQKSTVASdq-grNPEWNEKFLFNISeg-----vsDLVIRIMDKDt 76  Sitka spruce
EEF29232       4 GTLEVELLNAKGLRGTDfl-gkIDPYVIIHYrsqERKSSVARdd-ggSPAWNEKLTFKVEypgq-gddyKLIFNIMDHDt 80  castor bean
XP_002270608   4 GTLEVLLINARRLKDKNfl-vkMDPYVLIQYgnqVRWSGVAKg---rNPEWNEKFTFNAEypggehhkyKLILRIMDKHk 79  wine grape
NP_001148526   4 GVLEVHLVDAKGLSGNDfl-gkLDPYVIMQYrsqERKSSVARdq-grNPCWNEVFKFQINsaaa-nvqhKLILRIMDHDn 80  maize
ABK22624       4 GTLEVLLVNAEGLENSDfl-cnMDPYVIIQCrtqQQKSSVASgq-gsNPEWNQQFVFTVAeg-----vtDLTLKIMDSDn 76  Sitka spruce
ACU14574       4 GTLEVVLISAKGIDDNDfl-ssIDPYVILTYraqEKKSTVQEda-gsKPQWNESFLFTVSds-----asELNLKIMDKDn 76  soybean
XP_002511861 567 GILEVLLVHAEGIRHTNli-grPAYYVITQCgnrVHESKVSSgk-dqEACWNEKFRFEFPlidw-krmtHLKFRIMDKEf 643 castor bean
NP_001118904   4 GILEVFLIDAHGITHTNfi-gtPVYYVLLQCgtkEYRSKMSKgd-ndNALWNQKFVFDFPmsqw-kkltYIKLRILDKEl 80  thale cress
Feature 1             #                                            
1WFJ_A        83 gt-edDAVGEATIPlepvFVEGSIPPTAYNVVKd--eEYKGEIWVALSFK 129 thale cress
Q9ZT46        82 id-gdDYIGDVKIDvqnlLAEGVRKGWSELPPRm--yQVLAHKIYFKGEI 128 winter squash
BAC41817      82 fs-sdDFIGEATVHvkelLEMGVEKGTAELRPTk--yNIVDSDLSFVGEL 128 thale cress
ABK26300      77 ft-adDFIGEANIPldgvFEAGNLPPLTYNVVMg--dYTYCGQIKVGLTF 123 Sitka spruce
EEF29232      81 fs-adDFIGQATIYvkdlLELGVENGVAELQPRk--yCVVQADNSYCGEI 127 castor bean
XP_002270608  80 lscidDFIGQTTIYvkdlVSMGVEMGQAHLRPTk--yRVVLPNQSYAGEI 127 wine grape
NP_001148526  81 fs-sdDFLGEATIDvtdiVSLGAERGTYHLNAAk--hNVVLADKTYHGEI 127 maize
ABK22624      77 an-edDFVGEASIPlegvFMEGSLPPTHYNVVLpdktYCGEIKVGLTFTI 125 Sitka spruce
ACU14574      77 fs-qdDCLGEATIHldpvFEAGSIPETAYKVVKde-eYCGEIKVALTFTA 124 soybean
XP_002511861 644 ft-dsGFVGETIIYlggiIAEGINKGILEVKPAp--yNVVLEDDTYKGEI 690 castor bean
NP_001118904  81 fn-dgGFVGETIIHlggiITEGRDRGYIEIKPAp--yNVVLEDDTFKGEL 127 thale cress

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