Conserved Protein Domain Family
C2A_Copine

?
cd04048: C2A_Copine 
C2 domain first repeat in Copine
There are 2 copies of the C2 domain present in copine, a protein involved in membrane trafficking, protein-protein interactions, and perhaps even cell division and growth. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-I topology.
Statistics
?
PSSM-Id: 176013
View PSSM: cd04048
Aligned: 93 rows
Threshold Bit Score: 98.0253
Threshold Setting Gi: 145513772
Created: 17-May-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                        #     #                                                          
Q9XUB9         15 TNVRLTISANNLMDLDVFSKSDPICLIYEKTsgrkattteeitvptwkdkqWTERGRTEVVMNNLNPQFTKTFLLP--YF 92   Caenorhabditi...
XP_001869207    8 PLCESAISCDNLLCDGNGKPPNPSVVVQVTStnrga-----------strgWVKYGRTEVIERSSNPQFVCTITFRagDG 76   southern hous...
XP_784481     127 PVLEMSISCNHLPMKSNGDEPSVFASINCMTppd---------------trWLNCGQTEIIDKQSNPFFVSTVVFEtsRN 191  purple urchin
XP_416886      44 PILEFSLACSELLTPSLDRKPNSFVAVSVTTppq---------------afWTKHAQTEIIEGTSNPIFLSSIAFFqdSL 108  chicken
NP_001089588   39 PILEFSLACSDLTTPSLDRKPNSFVAISVTTppq---------------afWTKHAQTEIIEGTSNPTFLSSIAFFqdSL 103  African clawe...
XP_002422892   41 PICEVSISCDNLLCDGHGRPPNPVVLVHVFLpte---------------nvWIKYAKTEVITRCSNPCFLTTVTFRdsDG 105  human body louse
XP_393548     195 PICEISLACDNLLCDGHGRPPNPVLEIDVQVkns---------------ktWIKYARTEVVERSSNPGFLTTITFRtsDG 259  honey bee
NP_001019788   39 PQLEFILACRDLVAPVSDRKLNTVVQISVIHpve---------------qtLTRYSSTEIVEGTKDPLFLTGVTFPpdYP 103  house mouse
XP_001639155  177 PLLEMCIACNGLISPIPDRLPNAFVEIRTMTpps---------------vsWSKHAQTEIIEQKSDPYFLTTVVFPsnGT 241  starlet sea a...
XP_420420      22 FSFVLSPACKDLVAATRDRKLNTFIQVSVVHpae---------------hvLTRYSSTEIVEGTRDPLFLTGVTFPpeYP 86   chicken
Feature 1                     # #                        #                                    
Q9XUB9         93 FEETQLLRFEIYDADsptv-------------gqdLSSHDFLGRFECVLAQiVSYSTLKAHLGk----tGQIGAQW 151  Caenorhabditis el...
XP_001869207   77 LNAASQIRFTAYDVRek-----------------vTQTAVPIGCAEVTLGAmLETPRLRIPLKt-----QNHQAGA 130  southern house mo...
XP_784481     192 IAVITRLRANIYAVEdr-----------------tNQSHCAIGHAICSFKDiIAAPGNKLVLNii--gaDDKPCGG 248  purple urchin
XP_416886     109 INQMTQIKLSVYDVKdr-----------------sQGTMYLLGSGMFTVKElLQEKNHRLHLTlrsaesDRVGNIT 167  chicken
NP_001089588  104 INQMTQIKLSVYDVKdr-----------------sQGTMYLLGFGKFTVKEvLREKNHRLCLTlw--saEQEPVGK 160  African clawed frog
XP_002422892  106 LTSDTRVRLSALDVRek-----------------vSQTAAPLGQAIITLSSiQESQKLRIPLRl-----SSAGTTV 159  human body louse
XP_393548     260 LSTETKVRISAYDVRer-----------------vSQTATPIGSAIVTLNTiQDTPRLRIPLKstktttVGFLTIN 318  honey bee
NP_001019788  104 IYEETRIKLTVYDVKdk-----------------sHDTRSFLGCASFKVGElLKSKEQLLSLSlrt-sdGGKVVGT 161  house mouse
XP_001639155  242 IQDVTRLKLAVFDVRdr-----------------dKEEMILLGHSMCTIRDiVSSPDKKLVLSlts-ldTSVPCGT 299  starlet sea anemone
XP_420420      87 IYEETKIKLTVYDVKdksqdtvhttvlpdhkeprtDVGRSFLGFTTFTVGDlVKSKEQQLTLTlrt-sdGGKTVGT 161  chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap