Conserved Protein Domain Family
C2B_Copine

?
cd04047: C2B_Copine 
C2 domain second repeat in Copine
There are 2 copies of the C2 domain present in copine, a protein involved in membrane trafficking, protein-protein interactions, and perhaps even cell division and growth. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-I topology.
Statistics
?
PSSM-Id: 176012
View PSSM: cd04047
Aligned: 90 rows
Threshold Bit Score: 84.1542
Threshold Setting Gi: 145513772
Created: 30-Dec-2004
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                       #       #                                                        
O75131       139 RVVLFEMEARKLDNKDLFg--KSDPYLEFHKQTSdg-nWLMVHRTEVVKNNLNPVWrPFKISLNSLCYGdmDKTIKVECY 215 human
XP_001303365 160 AVIEMQFKAKNLKKMHFLt--SNSPYFVISKGSE----SGSFLPVFQSEVSKKCQWkKFSIPYQTLCNCdpARPLKISVM 233 Trichomonas vag...
XP_001310194 169 TVLDLQIEAVKMKKMRTFs--KNQPFLMMSKLSEsg-vNIPVFRSEVIPKCYRCTWaPFRVSLQAVANGnaDCPILISLM 245 Trichomonas vag...
XP_001311650 170 AVATFQLAVRNLKKMHTFs--RNNPYIILSKGSEsg-rLLPSYKSEYCRKCASCTFrQADVSLQSLCNGdqEVPITVSVF 246 Trichomonas vag...
XP_001318799 169 SRVKMDFAFKNLKKVRTFh--SNRPYLVISKPSEtg-kLLPTYRSAVYPKCNSCNIkTFEIPLQSLCNGdmDVPLTLSAY 245 Trichomonas vag...
XP_001326995 163 EVVEMLISVKDLKRMRTFs--RNRPFFTITKANEsg-vEIPVYRSEVVPKCVSCTFnRFIVPLNAFCDGnlDTPMTIKVS 239 Trichomonas vag...
XP_002405524 148 GFAALQLSARNIPLKTFFr--TADSMLELWRQDTcg-tSALVHETDVVRNSGTPHWkKIILNKNRIGKD--SDAILIKCF 222 black-legged tick
XP_001898719  44 QAVRLQFKGHSLHAPSNDc--PLDAYFVMYLVPEd--aPKLLLHKSEAIAEKNPVWkTFLIPISHFSFAsaSCSIEIDVY 119 agent of lympha...
XP_001309187 135 GVLSMIVAFYNMPKDHWLm--KNYPELHICKQDSdsshWKSVRSTEVIKRQDAGQWdPISIPCRSICNNdySKKIRFKVV 212 Trichomonas vag...
XP_001442797 141 SNLLPLAADSLSRKCCIFnlqPSQPYIKISRTFQdtneSNLVYQSEPIKFPDRRTWpEIKKMARDICNNdsDAVLQIEIF 220 Paramecium tetr...
Feature 1        # #     #                                               
O75131       216 DYDNDgSHDLIGTFQTtmtklke--------------------asrsspvEFECIN 251 human
XP_001303365 234 HYRSTtHAEQIGFIETtyerise---------------------slmqtqDIMDEH 268 Trichomonas vaginalis G3
XP_001310194 246 DNHVSkPDQVIGSVQLtanniv-----------------------asigkDIDVMD 278 Trichomonas vaginalis G3
XP_001311650 247 NFRSGkVDELIGSFSAslnrlm-----------------------enqgqEFELKD 279 Trichomonas vaginalis G3
XP_001318799 246 DFREGkLDYLIGSAQMslkemm-----------------------entgtELVIKN 278 Trichomonas vaginalis G3
XP_001326995 240 DYHNFdPAKDIGAFQAs---------------------------------VKDLLE 262 Trichomonas vaginalis G3
XP_002405524 223 DVSFSgEKTYLGYAETnirelaq---------------------gtekrlEWQCKQ 257 black-legged tick
XP_001898719 120 NYNVNrEDKLIGKCTTsfdqlmrgigalna------yklssiegkkkrntSVELVD 169 agent of lymphatic filariasis
XP_001309187 213 DHPDDgPVVPIGYADAsvqdvsqfrnrvltlt---pynpkvarcgnlivrAATLIE 265 Trichomonas vaginalis G3
XP_001442797 221 DKGRS-NDIYIGSVNLsisqmldkkgqrnlqhkgnqcitgqlsiqkclfrEIPTFE 275 Paramecium tetraurelia strain d4-2

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap