Conserved Protein Domain Family
C2_Calpain

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cd04046: C2_Calpain 
C2 domain present in Calpain proteins
A single C2 domain is found in calpains (EC 3.4.22.52, EC 3.4.22.53), calcium-dependent, non-lysosomal cysteine proteases. Caplains are classified as belonging to Clan CA by MEROPS and include six families: C1, C2, C10, C12, C28, and C47. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176011
View PSSM: cd04046
Aligned: 21 rows
Threshold Bit Score: 134.713
Threshold Setting Gi: 17542636
Created: 17-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9Y6Q1       514 PKVVTQITVHSAEDLekky-aneTVNPYLVIKCGKEEVRSPVQKntvHAIFDTQAIFYRRtt-diPIIVQVWNSRKFCDQ 591  human
XP_792213    514 IRVVSQVNVLSASNLkkqdhfggGADPYVYVKCEGKTATSRVQKdtlNPEWNYNSIFYRRkp-gtPIIVEVWNHNVVKDS 592  purple urchin
AAT77812     514 AVMVTTITVKCASNLekqsafggDADAYCIIKCGGETVRTPVKG---QQSYMTPQPFYRAkp-eqPIVIEIWNSNMLVDG 589  blackback land...
XP_001626960 516 PQCVVSVYVTSAAGLqktgkmslTCDPYALIICEGRKIKTPIKYdtlIPSWDAGALFYVRqpqksQIVVQIWDSNWILDS 595  starlet sea an...
EEC05117     335 PCLATIVRIIGAKNLekqd-lfgTADPYCVVMCEGQSVRSGICHetlDPVWNLSAIFYRKds-ssAIKIQVWSSNVMMDT 412  black-legged tick
XP_002107604 514 PVAIVQIDAIAAKDLskknrsgvGASPYCIIKCGKESVRTPVIKetlNPKFDASAIFYLRnpnsaKAVIEIWSKGTVMDS 593  Trichoplax adh...
XP_002154752 579 SVIVTAVNNLKKKGSts-----mTVDPYCIIECEGCSVRTPVVTdnlNPTFNYGGIFYLRkp-esLLKIQVWDANTLVPD 652  green hydra
XP_001339053 819 SSAVTTVHLLKASGLshp--kktAPDVYAIIRCEEDSVRTRVFKkdeSPEFNTKAIFYSRkl-ksKISIELWRRGLLLDT 895  zebrafish
XP_002603439 523 PQAVTSVHLHSATGLs------kKQDTYAVIKSGSKSAKTRVIEdssSPEYDEEAIFYRKdp-rnPIKIQIWKKDLIRDD 595  Florida lancelet
XP_002131020 135 PSSAISVNVVNGVRLfne--eneLGNVYVKMTCEGVTVRSKTFRensEPYFDAGAIFYRKen-ryPVVFAVYHENRVCDE 211  Ciona intestin...
Q9Y6Q1       592 FLGQVTLdadp-sdcRDLKSLYLr----kKGGPTAKVKQGHIsfKVISSDDLT 639  human
XP_792213    593 FMGQAIFlag--nkgQPEHNVAVlk---kRGRDSEDAAGGQVsvVITTTDDLK 640  purple urchin
AAT77812     590 FIGRAEVtapi-npnYTQVQLSLy----gRRKEKTVEKQGHLlvQVYSDDDLT 637  blackback land crab
XP_001626960 596 FMGQVKIpvni-tnsKTQASYNLk----gRRREHDLQKPGTVtvQINAYHDLF 643  starlet sea anemone
EEC05117     413 YMAKAYVeapp-htdHVLREVPLvg---hKKRTDDGARLGTItlELTTTDDLL 461  black-legged tick
XP_002107604 594 FMGKAEIavel-nrnKVCDDLPLfsnkkpKKNEQPEKEPGTLsvKINCSDNLE 645  Trichoplax adhaerens
XP_002154752 653 TFLGEINnpievnnkTVLETHSLme--rkGRDGAVSKAEGTIsfKITASNNLT 703  green hydra
XP_001339053 896 FLGGARLqt-----gGSERGQNR------VIDLQGGQSRGSVfvEISSSHCLT 937  zebrafish
XP_002603439 596 LLGEATMmcev-nnsTKQHVVQL------QDKDGGGDVHGSIsvSVTSHDDLT 641  Florida lancelet
XP_002131020 212 FIGQGTVsgnv-efqKQPVEVPLfa---kNSWKAPKRFPGTLyvNVQTADSIK 260  Ciona intestinalis
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