Conserved Protein Domain Family
C2C_Tricalbin-like

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cd04045: C2C_Tricalbin-like 
C2 domain third repeat present in Tricalbin-like proteins
5 to 6 copies of the C2 domain are present in Tricalbin, a yeast homolog of Synaptotagmin, which is involved in membrane trafficking and sorting. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.
Statistics
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PSSM-Id: 176010
View PSSM: cd04045
Aligned: 33 rows
Threshold Bit Score: 135.024
Threshold Setting Gi: 213403828
Created: 30-Dec-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         #     #                                              # #    #   
CAY67482      653 GVARLHIRNADDVLNTKtvGKVDPYVRVMVNGrlKYRTTVREttTTPVWEECMYFPVtsmnqVFSLDVMDAEKRsKDKLL 732  Pichia pastor...
XP_001643952  771 GALRFRIHDALVKDSLKgvGDIDPYFNLLINNqiYYRSRYISenKNPSFDTTVYLPItsendVIALSLFDYQNVgKDRFI 850  Vanderwaltozy...
XP_002553432  787 GVARLHIQDALVDENLSgvGDIDPYITVSLNKriTHRTHYFSdnREPNFNAVVYIPVtsekqTIVVDVIDYQKVgKDRPI 866  Lachancea the...
XP_002495575  880 GALRVLVRDINVLDNLSglGDIDPYFTLSVNRhvDYKSISYSetEHAYFDKVDYLILmsekaSVTVNVYDYQSVgDDRFI 959  Zygosaccharom...
CAG62239      765 GVLKIFVRNAEINSSLSgiGDIDPYFSVSLNNvqRYRSKYQSenRSPTFNYMVYVPVtsdgqTITISLSDYQSVgSDRFI 844  Candida glabrata
2497080       798 GCIKLDVKDAIIKGDLSgvGDVDPYYTVSLNRrvLYKSIYHSdtDHPIFDNSTYVPIfspnqILTLEFHDYQKIgKDRFI 877  baker's yeast
EAL02703      529 GGMRLHLRGAKGLKNLEsvGYVDPYVRVMLNGklRAKTVTFAetVNPQWNSVYFLPVanehqHYLLQIMDAEPEgKDRSL 608  Candida albic...
CAG87027      668 GGLRIHLRSATGLKNLEavGKVDPYVRVMMNGniRGKTSTIAdtLDPAFNHVCFVPIandhqHILLEVMDEEADqNDRSL 747  Debaryomyces ...
EEQ36832      657 GGLRLHLLRASGLKNLEavGDVDPYVKVIQDGklKGKTPTIAntSDPVFNNVFYVPVanehqHILMDIFDAEPEgKDRPL 736  Clavispora lu...
NP_985007     744 GVIRMHIREASVQGELEgvGDIDPYFVISADKsvLFRSNFFSdqSNPKFNNLVYVPItspnqTVTLDLYDYQKIgKDRFI 823  Ashbya gossyp...
Feature 1                                                     
CAY67482      733 GSAKVQLSsfvkk-sddgkFMAYDGAKKVLSqpleiKKSKKKKG 775  Pichia pastoris GS115
XP_001643952  851 GRIQFHADklieaaikkenNNLASTESEKWVl----RDLRNRAT 890  Vanderwaltozyma polyspora DSM 70294
XP_002553432  867 GSYSIPVSkllek--ktdsGVIGQSDEPPSQc---rLLGKNMKL 905  Lachancea thermotolerans CBS 6340
XP_002495575  960 GSAQIPLEevmkkdpktdkFTLVDNSKKPLK-----LGLQNKKG 998  Zygosaccharomyces rouxii CBS 732
CAG62239      845 GSARVPVSkfakrdkktgrYQPYDKLDKSVKld--iLDKRGGET 886  Candida glabrata
2497080       878 GSVQIPTSnvfkkdpksgkYVGNNGKEEISKl---kLKDHEHKV 918  baker's yeast
EAL02703      609 GTAAINVAdilrk-neegyYLGYDGSDEIIEqp--vLFNTKEAG 649  Candida albicans SC5314
CAG87027      748 GTCAVHVNeflkk-ndegyYLGYDGSNEIIEqp--vLLNGQHQG 788  Debaryomyces hansenii
EEQ36832      737 GSCAVAVKdflkk-nskgyYLGYDGSKEIVEqp--vLYNGGNCG 777  Clavispora lusitaniae ATCC 42720
NP_985007     824 GSCHFKAAnimekdpgtdkYVPSGSADEVLEw---vLSDKSKRA 864  Ashbya gossypii ATCC 10895

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