Conserved Protein Domain Family
C2A_Tricalbin-like

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cd04044: C2A_Tricalbin-like 
C2 domain first repeat present in Tricalbin-like proteins
5 to 6 copies of the C2 domain are present in Tricalbin, a yeast homolog of Synaptotagmin, which is involved in membrane trafficking and sorting. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-II topology.
Statistics
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PSSM-Id: 176009
View PSSM: cd04044
Aligned: 33 rows
Threshold Bit Score: 127.286
Threshold Setting Gi: 19075365
Created: 17-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                  #                                                 # #  
1353095       377 IGVLEIKVKNAHGlrklvGMIKKTVDPYLTFELsg--kiVGKTKVFKNSANPVWNESIYILLq-sFTDPLTIAVYDKRET 453  baker's yeast
EAK86272      463 IGVLQVNIWSARNlk-gvKLGGGTPDPYVALSIdnr-dvLAKTSIKKGTANPQFKETKFVLLn-nLNGMLTMAIMDYNEH 539  Ustilago mayd...
EAL22271      462 IGVLRVTVLDARNlk-atKFGGGDPDPYVSFSIgak-paIAQTKTIRSTSNPSFHETQFLLIn-sLADVLNLNVFDFNDH 538  Cryptococcus ...
EED81501      456 IGVLQVTVQSARGlr-gsKISGGSPDPYVSLSInsr-seLARTKAKQDTANPTWSETKFLLVn-sLTESLILSVMDFNDH 532  Postia placen...
XP_001832502  453 IGVLEVMVHSARGvk-gsSLGDKTPDPYVSLAIdqr-paVARTKWRSNTTNPTWMETKYVLVn-kLEGKLNLHVYDYNDR 529  Coprinopsis c...
XP_001828627  440 VGVVQVTIHSARGik-gvKIGGGTPDPYVSLSIndr-aeLARTKWKHNTYNPTWVETKYILVn-sLHERLVLDLYDYNDH 516  Coprinopsis c...
CAY70536      338 SGIIEINVKKATHikavdTSGGNTVDPYVIFSFgg--keIARTSTIEDTREPIWNETIRFLVs-dFSEPLHLDMYDFNDF 414  Pichia pastor...
XP_001730900  459 CGVLQVTIWNARNle-rlGIEGGAPNAYVSVSLngg-peIDRTRTREADPNPTYRETKYVLLk-eLEGLLTLTPMEDNGS 535  Malassezia gl...
XP_002619796  371 IGLLSVHIKRIIDlksttDIKDNVFHPYVQLGLsnnpkvIEKTKVKKDTTQPVYLETKNLLVsalDGNHLLLNVFHMVPD 450  Clavispora lu...
NP_593974     434 LGAVEFKLRKGDGf---kDGLGGAVDPYVVIKNsad-rvIGKSKVAHNTGSPVFNETFYSVLn-sFSENLNLEVYDFNDI 508  fission yeast
Feature 1            #                                                
1353095       454 l-SDKKMGTVIFNLNKLh----aNHYHKNEKvhflrNSKPVGELTFDLRFFP 500  baker's yeast
EAK86272      540 r-PDSTLGQAAFDLKELm----dDPEQEHLStpvilDAKERGEVQYSLSYYP 586  Ustilago maydis 521
EAL22271      539 r-PDSLLGTVSHELGTLa----dDAEQEGIVgqilgGGKDRGTLRYDLSYFP 585  Cryptococcus neoformans var. neoformans B...
EED81501      533 r-KDSEIGSASFDMSKLr----eDASYEGLEapilkDGKDKGMIRYDVTFYP 579  Postia placenta Mad-698-R
XP_001832502  530 r-SNVKLSTASFDLALLr----eDSVQENITsrlmdGEKDRGELRYNVTYYP 576  Coprinopsis cinerea okayama7#130
XP_001828627  517 r-SDQKLGTTAFELSQLe----dDATHEGINgqllkDGKDRGELRYDVSFFP 563  Coprinopsis cinerea okayama7#130
CAY70536      415 r-KDQLVGNILYDLGAFm----dEDELSDLElpilrNNKRVGTLHLDMKYMP 461  Pichia pastoris GS115
XP_001730900  536 l-PPSRLGTTRFDLSSLh----eNPSPGRMNkalmySDEPVGSIMYSLDYFP 582  Malassezia globosa CBS 7966
XP_002619796  451 qkDDINLGLLEVPLADLl----qTEVQTGMVknileSGKVVGKIEYDLKWSP 498  Clavispora lusitaniae ATCC 42720
NP_593974     509 r-SDKLLGSAVLPLATLeampvtNDAFVELTl----KGKTVGRLNYDMKFHA 555  fission yeast

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