Conserved Protein Domain Family
C2A_MCTP_PRT

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cd04042: C2A_MCTP_PRT 
C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
MCTPs are involved in Ca2+ signaling at the membrane. MCTP is composed of a variable N-terminal sequence, three C2 domains, two transmembrane regions (TMRs), and a short C-terminal sequence. It is one of four protein classes that are anchored to membranes via a transmembrane region; the others being synaptotagmins, extended synaptotagmins, and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2+ but not phospholipids. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-II topology.
Statistics
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PSSM-Id: 176007
View PSSM: cd04042
Aligned: 16 rows
Threshold Bit Score: 174.001
Threshold Setting Gi: 242015762
Created: 17-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #     #                                              # #     #   
Q6DN14        262 QLDITLRRGQSLAARDrgGTSDPYVKFKIGGkEVFRSKIIHknlNPVWEEKACILVdhlrePLYIKVFDYDfglqDDFMG 341  human
XP_001900972   67 SVRICLKEGHNLVIRDasGSSDPYVKFKYKDrTYFKSSTIYknlNPIWDEEFTLLIddpttPIYMDVYDYDrwatDDYMG 146  agent of lymp...
XP_001637803    3 ALDIELKEGKDLAARDktGTSDPYVKFKADGrQIYKSRTISknlNPQWNEKFCVPIeditvPMVLKVFDFDrvgnDDPMG 82   starlet sea a...
XP_002116376   70 TLDINLREGANLIAKDlsGTSDPYVKFRYNNkLLYKSATIYrdlRPRWYEKFSLNIedvskFLYLKVYDYDfalkDDFMG 149  Trichoplax ad...
XP_001192314 2306 RLEVHLKEGKDLAVRDwsGKTNNKKVQDQQQ-AGYKSKTIVhnlNPRWNEVFSVAIedvtkPLHIHVFDYDigtsDDPMG 2384 purple urchin
XP_002120929  104 KLHIKLIGGEGLAARDsnGLSDPYVKIRINNrTVYKSKCCKltlDPRWDEDFAIEVdm-eaHVVLHVYDKDrgftDDFMG 182  Ciona intesti...
Q6DN12        195 LLTIHLKEGRNLVVRDrcGTSDPYVKFKLNGkTLYKSKVIYknlNPVWDEIVVLPIqsldqKLRVKVYDRDlt-tSDFMG 273  human
NP_491908     144 LMEVRLKNGEDLPVKDasGSSDPYVKFRYKDnIVYKSGTIFknlNPSWDEEFQMIVddvtcPIRLEVFDFDrfctDDFMG 223  nematode
XP_690994      16 LLTICLKEGRNLVIRDrcGTSDPYVKVKLDGkMVYKSKVVLknlNPVWNESFTFPIrsleqTVFIKVFDRDlt-sDDFMG 94   zebrafish
XP_002601991  208 TLDVTLKEGRRLAIRDkcGTSDPYVKFKYDGkQVYKSRIVYknlNPRWDETFSLPVddvtkPLVVKVFDYDrglqDDPMG 287  Florida lancelet
Feature 1                                                    
Q6DN14        342 SAFLDltqlelnrptDVTLTLkdphyp-dhdlgIILLSVILTP 383  human
XP_001900972  147 GAIIDlsqlrlfqmtIMKLKLreegn--denmgEVDIVVTISP 187  agent of lymphatic filariasis
XP_001637803   83 RATVElselevgkpiEMELDLegeeg---enlgKVAAVFTITP 122  starlet sea anemone
XP_002116376  150 EAYVDmatlelekitEIKLKLedpnaa-gkdlgYLLLTLTLTP 191  Trichoplax adhaerens
XP_001192314 2385 NAKFDlmtlktseptEVKLDLsddtt--deylgYIVLVFSLIP 2425 purple urchin
XP_002120929  183 AAEIDlatlt-qnpeEINLHLsdess--eeelgYINIHGHLTS 222  Ciona intestinalis
Q6DN12        274 SAFVIlsdlelnrttEHILKLedpnsl-eddmgVIVLNLNLVV 315  human
NP_491908     224 AAEVDmsqvkwctptEFHVELtdevn---qptgRVSVCVTITP 263  nematode
XP_690994      95 SCSVGldklelekttEMVLPLddpnsl-eedmgFIAIDICVSM 136  zebrafish
XP_002601991  288 HAYIDlasllidrkeEFKVELedphvvfvftagKKSLKLSLRT 330  Florida lancelet

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