Conserved Protein Domain Family
C2A_fungal

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cd04041: C2A_fungal 
C2 domain first repeat; fungal group
C2 domains were first identified in Protein Kinase C (PKC). C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176006
View PSSM: cd04041
Aligned: 20 rows
Threshold Bit Score: 143.556
Threshold Setting Gi: 50258430
Created: 17-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         #           #                                                   
EAK83283      573 GVLVVEIEYGEGLSAQDan------gkSDPYVVLAFAKFg--------RPLYSSRIIFEDLNPVWQETAFLLvskddira 638  Ustilago mayd...
EAA58941       62 FTLRFTFHRGVNLPVADfgt-----fsSDSYLVASLAVDvpqrhkqdpLPTYRTPTVRKNRDPVWEKEWTVAnvpa---c 133  Aspergillus n...
EAK86251      532 GVICFVLHQADDLAAADsn------gqSDPFVQASFARAg--------KPLFTSRIVRKRRDAVWQETGFLLvspdevrd 597  Ustilago mayd...
EAL21119       24 YTLRITFHKATNLPVADfgs-----qtSDPFILAQATTShksrhsqdpYLRFRTNTVRKTLEPVWEAPWVIAgvpe---d 95   Cryptococcus ...
XP_001828585  417 GVLVVTVRKAILKFNGNe--------kHDAYVTVGWSKLg--------KPMWSTRIISDSIVPVWEETTFLLvgsnevdi 480  Coprinopsis c...
XP_001594269  123 YTVRFTFHRAENLPASDlnt-----rsSDPFIIASLTSSllkrhkddpDLVLRTQTIHENTNPVWNKTWTVAgipg---s 194  Sclerotinia s...
XP_365397     105 FTVKFTFHRAWNLPIADipt-----aaADPFVHATLNADvpkrhkedpNLRHRTRTERKTLEPAWEEEWVVAnipr---t 176  Magnaporthe g...
XP_001793934  578 GVLIVRIKHAYDFKEGDgglgplkkgsADPYITVGWAKFg--------KPVWSTRVLLDNMEPYWEETGFVSvtsqelnv 649  Phaeosphaeria...
XP_959503      56 YTIKITFHKAINLPVADiqt-----vsADPYIHATLTADvpkrhpedpPLTRRTRTIHHSLEPVWEEDWIVAnvpt---t 127  Neurospora cr...
XP_389867      81 YTIRFIFHGASNLAPADfvt-----isSDPFLHATLKGTqpkrhkedpDLTYRTRTIQKTTEPQWDDEWVVAnvpp---t 152  Gibberella ze...
Feature 1                  # #     #                             
EAK83283      639 neSLSIQLWDSDARTADDIVGRVNTPIkdlirnanhvqDRTDKLMGF 685  Ustilago maydis 521
EAA58941      134 gfRLKCRVYDEDAADHDDKLGNAYIQVdsi-----saqWPGIQQQPF 175  Aspergillus nidulans FGSC A4
EAK86251      598 hdRLRFTVFDADRFSADDPLGKVEISLhrlir--kfrpDGEARSTNL 642  Ustilago maydis 521
EAL21119       96 glKLSVRVYDEDPQDHDDRLGKFEIDTgpi-----dekWQGLKQQSF 137  Cryptococcus neoformans var. neoformans B-3501A
XP_001828585  481 qeGLRLQVWDSDRFTADDLMGNVDVPLhdimhnhatrnHVSRREDHL 527  Coprinopsis cinerea okayama7#130
XP_001594269  195 gfRLKCRLYDEDPADHDDRLGNVTIYVesl-----gpnWQGFKEKAF 236  Sclerotinia sclerotiorum 1980
XP_365397     177 gfRLKCRLYDEDYPDSDDRLGNVTYISpmi-----denWPGLKRHTF 218  Magnaporthe grisea 70-15
XP_001793934  650 deRLRLQLWDSDRTTADDDLGRIELDLkdlmkseetngKMHDREDGF 696  Phaeosphaeria nodorum SN15
XP_959503     128 gfELKCRLYDEDWPDHDDRLGNVTIKVdhl-----dedWPGFGLDGK 169  Neurospora crassa OR74A
XP_389867     153 gfTLKCRLYDEDFPDHDDRLGNVTIKIpsisq-dwqgiPPPGRVYEA 198  Gibberella zeae PH-1

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